Impact of 18F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning–Generated Biomarkers

Stefan P. Haider; Tal Zeevi; Kariem Sharaf; Moritz Gross; Amit Mahajan; Benjamin H. Kann; Benjamin L. Judson; Manju L. Prasad; Barbara Burtness; Mariam Aboian; Martin Canis; Christoph A. Reichel; Philipp Baumeister; Seyedmehdi Payabvash

doi:10.2967/jnumed.123.266637

Research ArticleBasic Science Investigation

Impact of ¹⁸F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning–Generated Biomarkers

Stefan P. Haider, Tal Zeevi, Kariem Sharaf, Moritz Gross, Amit Mahajan, Benjamin H. Kann, Benjamin L. Judson, Manju L. Prasad, Barbara Burtness, Mariam Aboian, Martin Canis, Christoph A. Reichel, Philipp Baumeister and Seyedmehdi Payabvash

Journal of Nuclear Medicine May 2024, 65 (5) 803-809; DOI: https://doi.org/10.2967/jnumed.123.266637

Stefan P. Haider

1Department of Otorhinolaryngology, LMU Clinic of Ludwig Maximilians University of Munich, Munich, Germany;

2Section of Neuroradiology, Yale School of Medicine, New Haven, Connecticut;

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Tal Zeevi

2Section of Neuroradiology, Yale School of Medicine, New Haven, Connecticut;

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Kariem Sharaf

1Department of Otorhinolaryngology, LMU Clinic of Ludwig Maximilians University of Munich, Munich, Germany;

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Moritz Gross

2Section of Neuroradiology, Yale School of Medicine, New Haven, Connecticut;

3Charité Center for Diagnostic and Interventional Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany;

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Amit Mahajan

2Section of Neuroradiology, Yale School of Medicine, New Haven, Connecticut;

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Benjamin H. Kann

4Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts;

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Benjamin L. Judson

5Division of Otolaryngology, Yale School of Medicine, New Haven, Connecticut;

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Manju L. Prasad

6Department of Pathology, Yale School of Medicine, New Haven, Connecticut; and

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Barbara Burtness

7Section of Medical Oncology, Yale School of Medicine, New Haven, Connecticut

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Mariam Aboian

2Section of Neuroradiology, Yale School of Medicine, New Haven, Connecticut;

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Martin Canis

1Department of Otorhinolaryngology, LMU Clinic of Ludwig Maximilians University of Munich, Munich, Germany;

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Christoph A. Reichel

1Department of Otorhinolaryngology, LMU Clinic of Ludwig Maximilians University of Munich, Munich, Germany;

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Philipp Baumeister

1Department of Otorhinolaryngology, LMU Clinic of Ludwig Maximilians University of Munich, Munich, Germany;

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Seyedmehdi Payabvash

2Section of Neuroradiology, Yale School of Medicine, New Haven, Connecticut;

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Journal of Nuclear Medicine

Vol. 65, Issue 5

May 1, 2024

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Impact of ¹⁸F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning–Generated Biomarkers

Journal of Nuclear Medicine May 2024, 65 (5) 803-809; DOI: 10.2967/jnumed.123.266637

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Impact of ¹⁸F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning–Generated Biomarkers

Journal of Nuclear Medicine May 2024, 65 (5) 803-809; DOI: 10.2967/jnumed.123.266637

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PET
SUV
normalization
radiomics
machine learning

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