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Research ArticleBasic Science Investigation

Design, Synthesis, and Preclinical Evaluation of a High-Affinity 18F-Labeled Radioligand for Myocardial Growth Hormone Secretagogue Receptor Before and After Myocardial Infarction

Rebecca Sullivan, Jinqiang Hou, Lihai Yu, Benjamin Wilk, Jane Sykes, Heather Biernaski, John Butler, Michael Kovacs, Justin Hicks, Jonathan D. Thiessen, Rohan Dharmakumar, Frank S. Prato, Gerald Wisenberg, Leonard G. Luyt and Savita Dhanvantari
Journal of Nuclear Medicine October 2024, 65 (10) 1633-1639; DOI: https://doi.org/10.2967/jnumed.124.267578
Rebecca Sullivan
1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;
2Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada;
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Jinqiang Hou
3Lakehead University and Thunder Bay Regional Health Research Institute, Thunder Bay, Ontario, Canada;
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Lihai Yu
4London Regional Cancer Program, London, Ontario, Canada;
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Benjamin Wilk
1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;
5Department of Medical Biophysics, Western University, London, Ontario, Canada;
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Jane Sykes
1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;
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Heather Biernaski
1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;
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John Butler
1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;
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Michael Kovacs
1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;
5Department of Medical Biophysics, Western University, London, Ontario, Canada;
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Justin Hicks
1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;
5Department of Medical Biophysics, Western University, London, Ontario, Canada;
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Jonathan D. Thiessen
1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;
5Department of Medical Biophysics, Western University, London, Ontario, Canada;
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Rohan Dharmakumar
6Indiana School of Medicine, Indianapolis, Indiana; and
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Frank S. Prato
1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;
5Department of Medical Biophysics, Western University, London, Ontario, Canada;
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Gerald Wisenberg
1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;
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Leonard G. Luyt
4London Regional Cancer Program, London, Ontario, Canada;
7Departments of Chemistry, Oncology, and Medical Imaging, Western University, London, Ontario, Canada
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Savita Dhanvantari
1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;
2Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada;
5Department of Medical Biophysics, Western University, London, Ontario, Canada;
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Article Information

vol. 65 no. 10 1633-1639
DOI 
https://doi.org/10.2967/jnumed.124.267578
PubMed 
39266294

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication February 22, 2024
  • Accepted for publication August 13, 2024
  • Published online October 1, 2024.

Article Versions

  • previous version (September 12, 2024 - 08:33).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2024 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Rebecca Sullivan1,2,
  2. Jinqiang Hou3,
  3. Lihai Yu4,
  4. Benjamin Wilk1,5,
  5. Jane Sykes1,
  6. Heather Biernaski1,
  7. John Butler1,
  8. Michael Kovacs1,5,
  9. Justin Hicks1,5,
  10. Jonathan D. Thiessen1,5,
  11. Rohan Dharmakumar6,
  12. Frank S. Prato1,5,
  13. Gerald Wisenberg1,
  14. Leonard G. Luyt*,4,7 and
  15. Savita Dhanvantari*,1,2,5
  1. 1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;
  2. 2Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada;
  3. 3Lakehead University and Thunder Bay Regional Health Research Institute, Thunder Bay, Ontario, Canada;
  4. 4London Regional Cancer Program, London, Ontario, Canada;
  5. 5Department of Medical Biophysics, Western University, London, Ontario, Canada;
  6. 6Indiana School of Medicine, Indianapolis, Indiana; and
  7. 7Departments of Chemistry, Oncology, and Medical Imaging, Western University, London, Ontario, Canada
  1. For correspondence or reprints, contact Savita Dhanvantari (sdhanvan{at}lawsonimaging.ca).
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 65 (10)
Journal of Nuclear Medicine
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October 1, 2024
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Design, Synthesis, and Preclinical Evaluation of a High-Affinity 18F-Labeled Radioligand for Myocardial Growth Hormone Secretagogue Receptor Before and After Myocardial Infarction
Rebecca Sullivan, Jinqiang Hou, Lihai Yu, Benjamin Wilk, Jane Sykes, Heather Biernaski, John Butler, Michael Kovacs, Justin Hicks, Jonathan D. Thiessen, Rohan Dharmakumar, Frank S. Prato, Gerald Wisenberg, Leonard G. Luyt, Savita Dhanvantari
Journal of Nuclear Medicine Oct 2024, 65 (10) 1633-1639; DOI: 10.2967/jnumed.124.267578

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Design, Synthesis, and Preclinical Evaluation of a High-Affinity 18F-Labeled Radioligand for Myocardial Growth Hormone Secretagogue Receptor Before and After Myocardial Infarction
Rebecca Sullivan, Jinqiang Hou, Lihai Yu, Benjamin Wilk, Jane Sykes, Heather Biernaski, John Butler, Michael Kovacs, Justin Hicks, Jonathan D. Thiessen, Rohan Dharmakumar, Frank S. Prato, Gerald Wisenberg, Leonard G. Luyt, Savita Dhanvantari
Journal of Nuclear Medicine Oct 2024, 65 (10) 1633-1639; DOI: 10.2967/jnumed.124.267578
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