Table of Contents

October 1, 2024; Volume 65,Issue 10

This Month in JNM

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This Month in JNM
Journal of Nuclear Medicine October 1, 2024, 65 (10) 6A;

Editor’s Page

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Is ChatGPT a Reliable Ghostwriter?
Irène Buvat and Wolfgang A. Weber

Journal of Nuclear Medicine October 1, 2024, 65 (10) 1499-1502; DOI: https://doi.org/10.2967/jnumed.124.268341

Commentary

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Navigating the Future of Prostate Cancer Care: AI-Driven Imaging and Theranostics Through the Lens of RELAINCE
Aaron Jun Ning Wong, Hyun Soo Ko and Michael S. Hofman

Journal of Nuclear Medicine October 1, 2024, 65 (10) 1503-1504; DOI: https://doi.org/10.2967/jnumed.124.267924

The State of the Art

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The Rise of Molecular Image–Guided Robotic Surgery
Fijs W.B. van Leeuwen, Tessa Buckle, Matthias N. van Oosterom and Daphne D.D. Rietbergen

Journal of Nuclear Medicine October 1, 2024, 65 (10) 1505-1511; DOI: https://doi.org/10.2967/jnumed.124.267783

Focus on Molecular Imaging

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Nuclear Imaging of Bispecific Antibodies on the Rise
Borna Roohani, Aldred Shane Mendez, Mann Dangarwala, Samantha Katz and Bernadette Marquez-Nostra

Journal of Nuclear Medicine October 1, 2024, 65 (10) 1512-1517; DOI: https://doi.org/10.2967/jnumed.123.267215

Is It Really Happening?

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1,090 Publications and 5 Years Later: Is FAP-Targeted Theranostics Really Happening?
Uwe Haberkorn, Annette Altmann, Frederik L. Giesel and Clemens Kratochwil

Journal of Nuclear Medicine October 1, 2024, 65 (10) 1518-1520; DOI: https://doi.org/10.2967/jnumed.124.267923

Oncology

Clinical
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  Association Between CA 15-3 and ¹⁸F-FDG PET/CT Findings in Recurrent Breast Cancer Patients at a Tertiary Referral Hospital in Kenya
  Margaret M. Mwania, Samuel Nguku Gitau, Jasmit Shah and Khalid Makhdomi
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1521-1525; DOI: https://doi.org/10.2967/jnumed.124.267851
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  Development of ¹⁸F-Fluoromisonidazole Hypoxia PET/CT Diagnostic Interpretation Criteria and Validation of Interreader Reliability, Reproducibility, and Performance
  Rick Wray, Audrey Mauguen, Laure Michaud, Doris Leithner, Randy Yeh, Nadeem Riaz, Rosna Mirtcheva, Eric Sherman, Richard Wong, John Humm, Nancy Lee and Heiko Schöder
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1526-1532; DOI: https://doi.org/10.2967/jnumed.124.267775
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  Diagnostic Accuracy of [¹⁸F]FDG PET/MRI in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Metaanalysis
  Akram Al-Ibraheem, Ahmed Abdlkadir, Ken Herrmann, Jamshed Bomanji, Hossein Jadvar, Hongcheng Shi, Asem Mansour, Diana Paez, Arturo Chiti and Andrew M. Scott
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1533-1539; DOI: https://doi.org/10.2967/jnumed.124.268049
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  Whole-Body HER2 Heterogeneity Identified on HER2 PET in HER2-Negative, -Low, and -Positive Metastatic Breast Cancer
  Bertha Eisses, Jasper J.L. van Geel, Adrienne H. Brouwers, Frederike Bensch, Sjoerd G. Elias, Evelien J.M. Kuip, Agnes Jager, Bert van der Vegt, Marjolijn N. Lub-de Hooge, Jasper Emmering, Anne I.J. Arens, Gerben J.C. Zwezerijnen, Daniëlle J. Vugts, C. Willemien Menke-van der Houven van Oordt, Elisabeth G.E. de Vries and Carolina P. Schröder
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1540-1547; DOI: https://doi.org/10.2967/jnumed.124.267636
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  Predicting Pathologic Complete Response in Locally Advanced Rectal Cancer with [⁶⁸Ga]Ga-FAPI-04 PET, [¹⁸F]FDG PET, and Contrast-Enhanced MRI: Lesion-to-Lesion Comparison with Pathology
  Xiao Zhang, Zhenyu Lin, Yuan Feng, Zhaoguo Lin, Kaixiong Tao, Tao Zhang and Xiaoli Lan
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1548-1556; DOI: https://doi.org/10.2967/jnumed.124.267581
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  Evaluating the Utility of ¹⁸F-FDG PET/CT in Cancer of Unknown Primary
  Tharani Sivakumaran, Anthony Cardin, Jason Callahan, Hui-li Wong, Richard W. Tothill, Rodney J. Hicks and Linda R. Mileshkin
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1557-1563; DOI: https://doi.org/10.2967/jnumed.123.267274
Basic
- Open Access
  Optimizing the Therapeutic Index of sdAb-Based Radiopharmaceuticals Using Pretargeting
  Sophie Poty, Laura Ordas, Yana Dekempeneer, Ali Asghar Parach, Laurent Navarro, Francis Santens, Nina Dumauthioz, Manuel Bardiès, Tony Lahoutte, Matthias D’Huyvetter and Jean-Pierre Pouget
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1564-1570; DOI: https://doi.org/10.2967/jnumed.124.267624

Theranostics

Clinical
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  Clinical Factors That Influence Repeat ⁶⁸Ga-PSMA-11 PET/CT Scan Positivity in Patients with Recurrent Prostate Cancer Under Observation After a Negative ⁶⁸Ga-PSMA-11 PET/CT Scan: A Single-Center Retrospective Study
  Pan Thin, Masatoshi Hotta, Andrei Gafita, Tristan Grogan, Johannes Czernin, Jeremie Calais and Ida Sonni
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1571-1576; DOI: https://doi.org/10.2967/jnumed.124.267591
- Open Access
  Composite Prediction Score to Interpret Bone Focal Uptake in Hormone-Sensitive Prostate Cancer Patients Imaged with [¹⁸F]PSMA-1007 PET/CT
  Matteo Bauckneht, Francesca D’Amico, Domenico Albano, Michele Balma, Camilla Cabrini, Francesco Dondi, Tania Di Raimondo, Virginia Liberini, Luca Sofia, Simona Peano, Mattia Riondato, Giuseppe Fornarini, Riccardo Laudicella, Luca Carmisciano, Egesta Lopci, Roberta Zanca, Marcello Rodari, Stefano Raffa, Maria Isabella Donegani, Daniela Dubois, Leonardo Peñuela, Cecilia Marini, Francesco Bertagna, Alberto Papaleo, Silvia Morbelli, Gianmario Sambuceti, Marta Ponzano and Alessio Signori
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1577-1583; DOI: https://doi.org/10.2967/jnumed.124.267751
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  Quantitative SPECT/CT Metrics in Early Prediction of [¹⁷⁷Lu]Lu-DOTATATE Treatment Response in Gastroenteropancreatic Neuroendocrine Tumor Patients
  Onur Tuncer, Daniel Steinberger, Joseph Steiner, Madeleine Hinojos, Stephanie Y. Rhee, Brad Humphrey, Farhad Jafari and Zuzan Cayci
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1584-1590; DOI: https://doi.org/10.2967/jnumed.124.267964
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  Dual Somatostatin Receptor/¹⁸F-FDG PET/CT Imaging in Patients with Well-Differentiated, Grade 2 and 3 Gastroenteropancreatic Neuroendocrine Tumors
  Ur Metser, Jose E. Nunez, David Chan, Roshini Kulanthaivelu, Vanessa Murad, Anna T. Santiago and Simron Singh
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1591-1596; DOI: https://doi.org/10.2967/jnumed.124.267982
- FEATURED ARTICLE OF THE MONTH
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    [⁶⁸Ga]Ga-RAYZ-8009: A Glypican-3–Targeted Diagnostic Radiopharmaceutical for Hepatocellular Carcinoma Molecular Imaging—A First-in-Human Case Series
    Alex J. Poot, Constantin Lapa, Wolfgang A. Weber, Marnix G.E.H. Lam, Matthias Eiber, Alexander Dierks, Ralph A. Bundschuh and Arthur J.A.T. Braat
    
    Journal of Nuclear Medicine October 1, 2024, 65 (10) 1597-1603; DOI: https://doi.org/10.2967/jnumed.124.268147
Basic
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  Preclinical Evaluation of ¹⁷⁷Lu-OncoFAP-23, a Multivalent FAP-Targeted Radiopharmaceutical Therapeutic for Solid Tumors
  Andrea Galbiati, Matilde Bocci, Domenico Ravazza, Jacqueline Mock, Ettore Gilardoni, Dario Neri and Samuele Cazzamalli
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1604-1610; DOI: https://doi.org/10.2967/jnumed.124.268200
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  Theranostic GPA33-Pretargeted Radioimmunotherapy of Human Colorectal Carcinoma with a Bivalent ¹⁷⁷Lu-Labeled Radiohapten
  Brett A. Vaughn, Sang-gyu Lee, Daniela Burnes Vargas, Shin Seo, Sara S. Rinne, Hong Xu, Hong-fen Guo, Alexandre B. Le Roux, Leah Gajecki, Simone Krebs, Guangbin Yang, Ouathek Ouerfelli, Pat B. Zanzonico, Edward K. Fung, Samantha St. Jean, Sebastian E. Carrasco, Achim Jungbluth, Nai Kong V. Cheung, Steven M. Larson, Darren R. Veach and Sarah M. Cheal
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1611-1618; DOI: https://doi.org/10.2967/jnumed.124.267685
- FEATURED BASIC SCIENCE ARTICLE
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    The Emission of Internal Conversion Electrons Rather Than Auger Electrons Increased the Nucleus-Absorbed Dose for ¹⁶¹Tb Compared with ¹⁷⁷Lu with a Higher Dose Response for [¹⁶¹Tb]Tb-DOTA-LM3 Than for [¹⁶¹Tb]Tb-DOTATATE
    Kaat Spoormans, Lara Struelens, Koen Vermeulen, Marijke De Saint-Hubert, Michel Koole and Melissa Crabbé
    
    Journal of Nuclear Medicine October 1, 2024, 65 (10) 1619-1625; DOI: https://doi.org/10.2967/jnumed.124.267873
- Open Access
  Molecular Imaging of p53 in Mouse Models of Cancer Using a Radiolabeled Antibody TAT Conjugate with SPECT
  Hudson Alakonya, Sofia Koustoulidou, Samantha L. Hopkins, Mathew Veal, Javier Ajenjo, Deborah Sneddon, Gemma Dias, Michael Mosley, Julia Baguña Torres, Francesca Amoroso, Amanda Anderson, Alison H. Banham and Bart Cornelissen
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1626-1632; DOI: https://doi.org/10.2967/jnumed.124.267736

Cardiovascular

Basic
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  Design, Synthesis, and Preclinical Evaluation of a High-Affinity ¹⁸F-Labeled Radioligand for Myocardial Growth Hormone Secretagogue Receptor Before and After Myocardial Infarction
  Rebecca Sullivan, Jinqiang Hou, Lihai Yu, Benjamin Wilk, Jane Sykes, Heather Biernaski, John Butler, Michael Kovacs, Justin Hicks, Jonathan D. Thiessen, Rohan Dharmakumar, Frank S. Prato, Gerald Wisenberg, Leonard G. Luyt and Savita Dhanvantari
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1633-1639; DOI: https://doi.org/10.2967/jnumed.124.267578

Endocrinology

Clinical
- BRIEF COMMUNICATION
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    C-X-C Motif Chemokine Receptor 4–Directed Scintigraphy Using [^99mTc]Tc-Pentixatec in Primary Aldosteronism: A Proof-of-Concept Study
    Johanna S. Enke, Kathrin Ritzel, Evelyn Asbach, Nic G. Reitsam, Bruno Märkl, Thomas Knösel, Denise Brüdgam, Malte Kircher, Christian H. Pfob, Ralph A. Bundschuh, Andreas Rinscheid, Bernd Nittbaur, Georgine Wienand, Margret Schottelius, Martin Reincke, Constantin Lapa and Alexander Dierks
    
    Journal of Nuclear Medicine October 1, 2024, 65 (10) 1640-1644; DOI: https://doi.org/10.2967/jnumed.124.268169

Neurology

Clinical
- Open Access
  Improving ¹⁸F-FDG PET Quantification Through a Spatial Normalization Method
  Daewoon Kim, Seung Kwan Kang, Seong A. Shin, Hongyoon Choi and Jae Sung Lee
  
  Journal of Nuclear Medicine October 1, 2024, 65 (10) 1645-1651; DOI: https://doi.org/10.2967/jnumed.123.267360

AI/Advanced Image Analysis

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Ultrashort Oncologic Whole-Body [¹⁸F]FDG Patlak Imaging Using LAFOV PET
Joyce van Sluis, Johannes H. van Snick, Andor W.J.M. Glaudemans, Riemer H.J.A. Slart, Walter Noordzij, Adrienne H. Brouwers, Rudi A.J.O. Dierckx, Adriaan A. Lammertsma, Charalampos Tsoumpas and Ronald Boellaard

Journal of Nuclear Medicine October 1, 2024, 65 (10) 1652-1657; DOI: https://doi.org/10.2967/jnumed.124.267784

The Illustrated Post

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[⁶⁸Ga]Ga-PSMA-11 PET/CT–Positive Hepatic Inflammatory Pseudotumor: Possible PSMA-Avid Pitfall in Nuclear Imaging
Fabio Monastero, Luigia Vetrone, Lina Cardisciani, Matteo Renzulli, Enrico Prosperi, Matteo Cescon, Matteo Ravaioli, Stefano Fanti, Andrea Farolfi and Francesco Vasuri

Journal of Nuclear Medicine October 1, 2024, 65 (10) 1658-1659; DOI: https://doi.org/10.2967/jnumed.124.267518

Departments

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Erratum
Journal of Nuclear Medicine October 1, 2024, 65 (10) 1651;