Theranostic GPA33-Pretargeted Radioimmunotherapy of Human Colorectal Carcinoma with a Bivalent 177Lu-Labeled Radiohapten

Brett A. Vaughn; Sang-gyu Lee; Daniela Burnes Vargas; Shin Seo; Sara S. Rinne; Hong Xu; Hong-fen Guo; Alexandre B. Le Roux; Leah Gajecki; Simone Krebs; Guangbin Yang; Ouathek Ouerfelli; Pat B. Zanzonico; Edward K. Fung; Samantha St. Jean; Sebastian E. Carrasco; Achim Jungbluth; Nai Kong V. Cheung; Steven M. Larson; Darren R. Veach; Sarah M. Cheal

doi:10.2967/jnumed.124.267685

Research ArticleBasic Science Investigation

Theranostic GPA33-Pretargeted Radioimmunotherapy of Human Colorectal Carcinoma with a Bivalent ¹⁷⁷Lu-Labeled Radiohapten

Brett A. Vaughn, Sang-gyu Lee, Daniela Burnes Vargas, Shin Seo, Sara S. Rinne, Hong Xu, Hong-fen Guo, Alexandre B. Le Roux, Leah Gajecki, Simone Krebs, Guangbin Yang, Ouathek Ouerfelli, Pat B. Zanzonico, Edward K. Fung, Samantha St. Jean, Sebastian E. Carrasco, Achim Jungbluth, Nai Kong V. Cheung, Steven M. Larson, Darren R. Veach and Sarah M. Cheal

Journal of Nuclear Medicine October 2024, 65 (10) 1611-1618; DOI: https://doi.org/10.2967/jnumed.124.267685

Brett A. Vaughn

1Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, New York;

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York;

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Sang-gyu Lee

3Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

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Daniela Burnes Vargas

1Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, New York;

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Shin Seo

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York;

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Sara S. Rinne

1Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, New York;

4Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York;

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Hong Xu

4Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York;

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Hong-fen Guo

4Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York;

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Alexandre B. Le Roux

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York;

3Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

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Leah Gajecki

3Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

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Simone Krebs

3Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

5Department of Radiology, Weill Cornell Medicine, New York, New York;

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Guangbin Yang

6Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York;

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Ouathek Ouerfelli

6Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York;

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Pat B. Zanzonico

7Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York;

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Edward K. Fung

8Department of Medical Physics, Weill Cornell Medicine, New York, New York;

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Samantha St. Jean

9Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center–Weill Cornell Medicine–Rockefeller University, New York, New York; and

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Sebastian E. Carrasco

9Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center–Weill Cornell Medicine–Rockefeller University, New York, New York; and

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Achim Jungbluth

10Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York

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Nai Kong V. Cheung

4Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York;

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Steven M. Larson

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York;

3Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

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Darren R. Veach

3Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;

5Department of Radiology, Weill Cornell Medicine, New York, New York;

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Sarah M. Cheal

1Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, New York, New York;

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York;

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Theranostic GPA33-Pretargeted Radioimmunotherapy of Human Colorectal Carcinoma with a Bivalent ¹⁷⁷Lu-Labeled Radiohapten

Journal of Nuclear Medicine Oct 2024, 65 (10) 1611-1618; DOI: 10.2967/jnumed.124.267685

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Theranostic GPA33-Pretargeted Radioimmunotherapy of Human Colorectal Carcinoma with a Bivalent ¹⁷⁷Lu-Labeled Radiohapten

Journal of Nuclear Medicine Oct 2024, 65 (10) 1611-1618; DOI: 10.2967/jnumed.124.267685

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Keywords

pretargeted radioimmunotherapy
177Lu
GPA33
colorectal cancer
multivalent

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