Article Figures & Data
Figures
- FIGURE 1.
Five-point PRIMARY score (4).
- FIGURE 2.
Cohen κ-coefficient for PRIMARY and PI-RADS divided into 2 categories or left as 5 categories. Overall coefficient and 95% CI are presented as thicker symbols and lines, with pairwise interrater values presented next to these as thinner, fainter symbols and lines.
- FIGURE 3.
Sensitivity vs. (1 − specificity) overall for 68Ga-PSMA PET and MRI derived from PRIMARY and PI-RADS scores, respectively. Faint markers and lines denote individual readers.
- FIGURE 4.
Cumulative percentage distribution of ISUP grade group by positive or negative 68Ga-PSMA PET result and 3 categories of PI-RADS. GG = grade group.
- FIGURE 5.
PSMA PET imaging for patient with ISUP grade group 5 on histopathology, negative result on 68Ga-PSMA PET central read, and PI-RADS 3 on MRI. Central readers had 1-h training session on PRIMARY score with little prior exposure, and this lesion was missed by both readers. This image is technically PRIMARY score 4 (arrows) with focal lesion apically (SUVmax, 3.5).
- FIGURE 6.
Horizontal box plot of SUVmax by ISUP grade group, taken as mean of 2 readers’ reports. Not shown are 1 ISUP grade group 3 lesion (SUVmax, 62) and 2 ISUP grade group 5 lesions (SUVmax, 44 and 46).
Tables
Characteristic Data Age (y) 68 (61–74) PSA (ng/mL) 6.8 (4.8–10.3) Days from MRI to biopsy 33 (14–79) Days from PET to biopsy 15 (6–35) Grade group No cancer 58 (26) 1 16 (7.0) 2 49 (22) 3 35 (15) 4 13 (5.7) 5 56 (25) PI-RADS* 1 2 (0.9) 2 70 (31) 3 26 (11) 4 56 (25) 5 73 (32) PRIMARY† Negative (1,2) 78 (34) Positive (3–5) 149 (66) Parameter Sensitivity Specificity Positive predictive value Negative predictive value PRIMARY 86% (79%–91%) 76% (64%–85%) 88% (82%–93%) 72% (61%–81%), PI-RADS 89% (83%–93%) 74% (63%–84%) 88% (82%–93% 76% (65%–86%) Combination 94% (89%–97%) 68% (56%–78%). 86% (80%–91%) 85% (73%–93%)
Supplemental Data
Files in this Data Supplement:
