Table of Contents

January 1, 2024; Volume 65,Issue 1

This Month in JNM

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This Month in JNM
Journal of Nuclear Medicine January 1, 2024, 65 (1) 10A;

Discussions with Leaders

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Expanding the Mission and Influence of SNMMI
Virginia Pappas and Johannes Czernin

Journal of Nuclear Medicine January 1, 2024, 65 (1) 1-3; DOI: https://doi.org/10.2967/jnumed.123.267086

State of the Art

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Artificial Intelligence for PET and SPECT Image Enhancement
Vibha Balaji, Tzu-An Song, Masoud Malekzadeh, Pedram Heidari and Joyita Dutta

Journal of Nuclear Medicine January 1, 2024, 65 (1) 4-12; DOI: https://doi.org/10.2967/jnumed.122.265000

Hot Topics

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Is It Time to Retire PIOPED?
Lionel S. Zuckier and Sean Logan Boone

Journal of Nuclear Medicine January 1, 2024, 65 (1) 13-15; DOI: https://doi.org/10.2967/jnumed.123.266186

Oncology

Clinical
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  Diagnostic Accuracy of MR Spectroscopic Imaging and ¹⁸F-FET PET for Identifying Glioma: A Biopsy-Controlled Hybrid PET/MRI Study
  Jörg Mauler, Philipp Lohmann, Andrew A. Maudsley, Sulaiman Sheriff, Moritz Hoevels, Anna-Katharina Meissner, Christina Hamisch, Anna Brunn, Martina Deckert, Christian P. Filss, Gabriele Stoffels, Jürgen Dammers, Maximillian I. Ruge, Norbert Galldiks, Felix M. Mottaghy, Karl-Josef Langen and N. Jon Shah
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 16-21; DOI: https://doi.org/10.2967/jnumed.123.265868
- BRIEF COMMUNICATION
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    Increased Metabolic Activity of the Thymus and Lymph Nodes in Pediatric Oncology Patients After Coronavirus Disease 2019 Vaccination
    Gaurav Luthria, Lucia Baratto, Lisa Adams, Wipawee Morakote and Heike E. Daldrup-Link
    
    Journal of Nuclear Medicine January 1, 2024, 65 (1) 22-24; DOI: https://doi.org/10.2967/jnumed.123.266271
Basic
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  Noninvasive Monitoring of Immunotherapy in Lung Cancer by Lymphocyte Activation Gene 3 PET Imaging of Tumor-Infiltrating Lymphocytes
  Zhen Quan, Zhaoguo Han, Yang Yang, Jiannan Wang, Hui Wang, Lili Yang, Rong A, Xinxin Hu, Jing Wang, Xiaona Li, Xiaoqian Li, Hong Yu, Wei Chen, Kai Wang and Xilin Sun
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 25-32; DOI: https://doi.org/10.2967/jnumed.123.266002
- FEATURED BASIC SCIENCE ARTICLE
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    Preclinical Evaluation of Minigastrin Analogs and Proof-of-Concept [⁶⁸Ga]Ga-DOTA-CCK-66 PET/CT in 2 Patients with Medullary Thyroid Cancer
    Thomas Günther, Nadine Holzleitner, Oliver Viering, Roswitha Beck, Georgine Wienand, Alexander Dierks, Christian H. Pfob, Ralph A. Bundschuh, Malte Kircher, Constantin Lapa and Hans-Jürgen Wester
    
    Journal of Nuclear Medicine January 1, 2024, 65 (1) 33-39; DOI: https://doi.org/10.2967/jnumed.123.266537
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  Fibroblast Activation Protein–Targeted PET/CT with ¹⁸F-Fibroblast Activation Protein Inhibitor-74 for Evaluation of Gastrointestinal Cancer: Comparison with ¹⁸F-FDG PET/CT
  Weizhi Xu, Jiayu Cai, Tianxing Peng, Tinghua Meng, Yizhen Pang, Long Sun, Hua Wu, Jingjing Zhang, Xiaoyuan Chen and Haojun Chen
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 40-51; DOI: https://doi.org/10.2967/jnumed.123.266329
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  Immunohistochemical FAP Expression Reflects ⁶⁸Ga-FAPI PET Imaging Properties of Low- and High-Grade Intraductal Papillary Mucinous Neoplasms and Pancreatic Ductal Adenocarcinoma
  Anna-Maria Spektor, Ewgenija Gutjahr, Matthias Lang, Frederik M. Glatting, Thilo Hackert, Thomas Pausch, Christine Tjaden, Mathias Schreckenberger, Uwe Haberkorn and Manuel Röhrich
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 52-58; DOI: https://doi.org/10.2967/jnumed.123.266393
- BRIEF COMMUNICATION
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    Characterizing Normal Variant [⁶⁸Ga]Ga-FAPI-46 Uptake in the Epididymis
    Peter George Maliha, Masatoshi Hotta, Johannes Czernin and Jeremie Calais
    
    Journal of Nuclear Medicine January 1, 2024, 65 (1) 59-62; DOI: https://doi.org/10.2967/jnumed.123.266013

Theranostics

Clinical
- Open Access
  Examining the Relationship and Prognostic Significance of Cell-Free DNA Levels and the PSMA-Positive Tumor Volume in Men with Prostate Cancer: A Retrospective–Prospective [⁶⁸Ga]Ga-PSMA-11 PET/CT Study
  Kilian Kluge, Holger Einspieler, David Haberl, Clemens Spielvogel, Stefan Stoiber, Chrysoula Vraka, Laszlo Papp, Sabine Wunsch, Gerda Egger, Gero Kramer, Bernhard Grubmüller, Shahrokh Shariat, Marcus Hacker, Lukas Kenner and Alexander Haug
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 63-70; DOI: https://doi.org/10.2967/jnumed.123.266158
- Open Access
  Renal and Multiorgan Safety of ¹⁷⁷Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer in the VISION Dosimetry Substudy
  Ken Herrmann, Kambiz Rahbar, Matthias Eiber, Richard Sparks, Nicholas Baca, Bernd J. Krause, Michael Lassmann, Walter Jentzen, Jun Tang, Daniela Chicco, Patrick Klein, Lars Blumenstein, Jean-René Basque and Jens Kurth
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 71-78; DOI: https://doi.org/10.2967/jnumed.123.265448
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  Long-Term Nephrotoxicity of ¹⁷⁷Lu-PSMA Radioligand Therapy
  Lisa Steinhelfer, Lukas Lunger, Lisena Cala, Christian H. Pfob, Constantin Lapa, Philipp E. Hartrampf, Andreas K. Buck, Hannah Schäfer, Christoph Schmaderer, Robert Tauber, Julia Brosch-Lenz, Bernhard Haller, Valentin H. Meissner, Karina Knorr, Wolfgang A. Weber and Matthias Eiber
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 79-84; DOI: https://doi.org/10.2967/jnumed.123.265986
- INVITED PERSPECTIVE
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    Unraveling the Impact of ¹⁷⁷Lu-PSMA Radioligand Therapy on Renal Impairment: Distinguishing Causation from Correlation
    Aravind S. Ravi Kumar and Michael S. Hofman
    
    Journal of Nuclear Medicine January 1, 2024, 65 (1) 85-86; DOI: https://doi.org/10.2967/jnumed.123.266638
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  Comparison of Multiple Segmentation Methods for Volumetric Delineation of Primary Prostate Cancer with Prostate-Specific Membrane Antigen–Targeted ¹⁸F-DCFPyL PET/CT
  Felicia Wang, Chen Liu, Igor Vidal, Margarita Mana-Ay, Andrew F. Voter, Lilja B. Solnes, Ashley E. Ross, Andrei Gafita, Edward M. Schaeffer, Trinity J. Bivalacqua, Kenneth J. Pienta, Martin G. Pomper, Martin A. Lodge, Daniel Y. Song, Jorge D. Oldan, Mohamad E. Allaf, Angelo M. De Marzo, Sara Sheikhbahaei, Michael A. Gorin and Steven P. Rowe
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 87-93; DOI: https://doi.org/10.2967/jnumed.123.266005
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  Reproducibility and Accuracy of the PRIMARY Score on PSMA PET and of PI-RADS on Multiparametric MRI for Prostate Cancer Diagnosis Within a Real-World Database
  Louise Emmett, Nathan Papa, William Counter, Jeremie Calais, Francesco Barbato, Irene Burger, Matthias Eiber, Matthew J. Roberts, Shikha Agrawal, Anthony Franklin, Alan Xue, Krishan Rasiah, Nikeith John, Daniel Moon, Mark Frydenberg, John Yaxley, Phillip Stricker, Keith Wong, Geoff Coughlin, Troy Gianduzzo, Boon Kua, Bao Ho, Andrew Nguyen, Victor Liu, Jonathan Lee, Edward Hsiao, Tom Sutherland, Elisa Perry, Wolfgang P. Fendler and Thomas A. Hope
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 94-99; DOI: https://doi.org/10.2967/jnumed.123.266164
Basic
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  Preclinical Development of PNT6555, a Boronic Acid–Based, Fibroblast Activation Protein-α (FAP)–Targeted Radiotheranostic for Imaging and Treatment of FAP-Positive Tumors
  Sarah E. Poplawski, Robin M. Hallett, Mark H. Dornan, Kyle E. Novakowski, Shuang Pan, Anthony P. Belanger, Quang-De Nguyen, Wengen Wu, Albert E. Felten, Yuxin Liu, Shin Hye Ahn, Valerie S. Hergott, Barry Jones, Jack H. Lai, Joe A.B. McCann and William W. Bachovchin
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 100-108; DOI: https://doi.org/10.2967/jnumed.123.266345
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  ²¹²Pb-Pretargeted Theranostics for Pancreatic Cancer
  David Bauer, Lukas M. Carter, Mohamed I. Atmane, Roberto De Gregorio, Alexa Michel, Spencer Kaminsky, Sebastien Monette, Mengshi Li, Michael K. Schultz and Jason S. Lewis
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 109-116; DOI: https://doi.org/10.2967/jnumed.123.266388

Endocrinology

Clinical
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  Clinical Value of ⁶⁸Ga-Pentixafor PET/CT in Subtype Diagnosis of Primary Aldosteronism Patients with Adrenal Micronodules
  Jie Ding, Xiang Li, Shengyan Liu, Yinjie Gao, Guoyang Zheng, Marcus Hacker, Yushi Zhang, Anli Tong and Li Huo
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 117-124; DOI: https://doi.org/10.2967/jnumed.123.266061

Radiobiology/Dosimetry

Clinical
- Open Access
  Quality Assurance Considerations in Radiopharmaceutical Therapy Dosimetry Using PLANETDose: An International Atomic Energy Agency Study
  Gunjan Kayal, Nathaly Barbosa, Carlos Calderón Marín, Ludovic Ferrer, José-Alejandro Fragoso-Negrín, Darko Grosev, Santosh Kumar Gupta, Nur Rahmah Hidayati, Tumelo C.G. Moalosi, Gian Luca Poli, Parul Thakral, Virginia Tsapaki, Sébastien Vauclin, Alex Vergara-Gil, Peter Knoll, Robert F. Hobbs and Manuel Bardiès
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 125-131; DOI: https://doi.org/10.2967/jnumed.122.265340

Cardiovascular

Clinical
- FEATURED ARTICLE OF THE MONTH
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    Imaging of Myocardial α_vβ₃ Integrin Expression for Evaluation of Myocardial Injury After Acute Myocardial Infarction
    Wail Nammas, Christian Paunonen, Jarmo Teuho, Reetta Siekkinen, Pauliina Luoto, Meeri Käkelä, Ari Hietanen, Tapio Viljanen, Matthieu Dietz, John O. Prior, Xiang-Guo Li, Anne Roivainen, Juhani Knuuti and Antti Saraste
    
    Journal of Nuclear Medicine January 1, 2024, 65 (1) 132-138; DOI: https://doi.org/10.2967/jnumed.123.266148
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  Automated Motion Correction for Myocardial Blood Flow Measurements and Diagnostic Performance of ⁸²Rb PET Myocardial Perfusion Imaging
  Keiichiro Kuronuma, Chih-Chun Wei, Ananya Singh, Mark Lemley, Sean W. Hayes, Yuka Otaki, Mark C. Hyun, Serge D. Van Kriekinge, Paul Kavanagh, Cathleen Huang, Donghee Han, Damini Dey, Daniel S. Berman and Piotr J. Slomka
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 139-146; DOI: https://doi.org/10.2967/jnumed.123.266208

Neurology

Clinical
- Open Access
  MRI or ¹⁸F-FDG PET for Brain Age Gap Estimation: Links to Cognition, Pathology, and Alzheimer Disease Progression
  Elena Doering, Georgios Antonopoulos, Merle Hoenig, Thilo van Eimeren, Marcel Daamen, Henning Boecker, Frank Jessen, Emrah Düzel, Simon Eickhoff, Kaustubh Patil, Alexander Drzezga and for the Alzheimer’s Disease Neuroimaging Initiative and the DELCODE Study Group
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 147-155; DOI: https://doi.org/10.2967/jnumed.123.265931

AI/Advanced Image Analysis

Clinical
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  Prognostic Value of ¹⁸F-FDG PET Radiomics Features at Baseline in PET-Guided Consolidation Strategy in Diffuse Large B-Cell Lymphoma: A Machine-Learning Analysis from the GAINED Study
  Thomas Carlier, Gauthier Frécon, Diana Mateus, Mira Rizkallah, Françoise Kraeber-Bodéré, Salim Kanoun, Paul Blanc-Durand, Emmanuel Itti, Steven Le Gouill, René-Olivier Casasnovas, Caroline Bodet-Milin and Clément Bailly
  
  Journal of Nuclear Medicine January 1, 2024, 65 (1) 156-162; DOI: https://doi.org/10.2967/jnumed.123.265872

Illustrated Post

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C-X-C Motif Chemokine Receptor 4–Directed Scintigraphy of Multiple Myeloma Using [^99mTc]Tc-PentixaTec
Johanna S. Enke, Nic G. Reitsam, Bianca Grosser, Malte Kircher, Alexander Dierks, Ralph A. Bundschuh, Georgine Wienand, Luise Uhrmacher, Martin Trepel, Margret Schottelius, Constantin Lapa and Christian H. Pfob

Journal of Nuclear Medicine January 1, 2024, 65 (1) 163-164; DOI: https://doi.org/10.2967/jnumed.123.266305

Letter to the Editor

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Debating the Future of Nuclear Medicine: The Greek Experience
Panagiotis Georgoulias, George Angelidis, Sophia Koukouraki and John Koutsikos

Journal of Nuclear Medicine January 1, 2024, 65 (1) 165; DOI: https://doi.org/10.2967/jnumed.123.266646

DEPARTMENTS

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Erratum
Journal of Nuclear Medicine January 1, 2024, 65 (1) 58;