Research ArticleBasic Science Investigation

Immunohistochemical FAP Expression Reflects 68Ga-FAPI PET Imaging Properties of Low- and High-Grade Intraductal Papillary Mucinous Neoplasms and Pancreatic Ductal Adenocarcinoma

Anna-Maria Spektor, Ewgenija Gutjahr, Matthias Lang, Frederik M. Glatting, Thilo Hackert, Thomas Pausch, Christine Tjaden, Mathias Schreckenberger, Uwe Haberkorn and Manuel Röhrich
Journal of Nuclear Medicine January 2024, 65 (1) 52-58; DOI: https://doi.org/10.2967/jnumed.123.266393

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  • FIGURE 1.
    FIGURE 1.

    Mean values (±SEM) of FAP IRS (A), Her2/neu score (B), intensity score (C), and percentage score (D) of LG IPMNs, HG IPMNs, HG IPMNs with PDAC, and PDAC. P values are for 1-way ANOVA with Bonferroni multiple-comparison tests. *P < 0.05. **P < 0.01. ***P < 0.001. ****P < 0.0001.

  • FIGURE 2.
    FIGURE 2.

    Mean values (±SEM) of αSMA IRS (A), Her2/neu score (B), intensity score (C), and percentage score (D) of LG IPMNs, HG IPMNs, HG IPMNs with PDAC, and PDAC. P values are for 1-way ANOVA with Bonferroni multiple-comparison tests. *P < 0.05. ***P < 0.001. ****P < 0.0001.

  • FIGURE 3.
    FIGURE 3.

    Comparison of mean values (with SD) of IRS with SUVmax (A), SUVmean (B), and TTP (C) of LG IPMNs, HG IPMNs, and HG IPMNs plus PDAC as parameters of static and dynamic 68Ga-FAPI-74 PET imaging observed in our previous study.

  • FIGURE 4.
    FIGURE 4.

    Representative hematoxylin and eosin staining (×20), immunohistochemical staining against FAP (×20), and corresponding axial PET/CT with 68Ga-FAPI-74 images of 3 patients with LG IPMNs in pancreatic tail, HG IPMNs in pancreatic head, and HG IPMNs plus PDAC in pancreatic head (scale bars = 50 μm; arrows indicate pancreatic lesions). HE = hematoxylin and eosin; IHC = immunohistochemistry.

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