Phase I Study of [68Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)

Odrade Gondry; Catarina Xavier; Laurens Raes; Johannes Heemskerk; Nick Devoogdt; Hendrik Everaert; Karine Breckpot; Quentin Lecocq; Lore Decoster; Christel Fontaine; Denis Schallier; Sandrine Aspeslagh; Ilse Vaneycken; Geert Raes; Jo A. Van Ginderachter; Tony Lahoutte; Vicky Caveliers; Marleen Keyaerts

doi:10.2967/jnumed.122.264853

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Phase I Study of [⁶⁸Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)

Odrade Gondry, Catarina Xavier, Laurens Raes, Johannes Heemskerk, Nick Devoogdt, Hendrik Everaert, Karine Breckpot, Quentin Lecocq, Lore Decoster, Christel Fontaine, Denis Schallier, Sandrine Aspeslagh, Ilse Vaneycken, Geert Raes, Jo A. Van Ginderachter, Tony Lahoutte, Vicky Caveliers and Marleen Keyaerts

Journal of Nuclear Medicine September 2023, 64 (9) 1378-1384; DOI: https://doi.org/10.2967/jnumed.122.264853

Odrade Gondry

1MIMA, Department of Medical Imaging, Vrije Universiteit Brussel, Brussels, Belgium;

2Nuclear Medicine Department, Universitair Ziekenhuis Brussel, Brussels, Belgium;

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Catarina Xavier

1MIMA, Department of Medical Imaging, Vrije Universiteit Brussel, Brussels, Belgium;

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Laurens Raes

2Nuclear Medicine Department, Universitair Ziekenhuis Brussel, Brussels, Belgium;

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Johannes Heemskerk

2Nuclear Medicine Department, Universitair Ziekenhuis Brussel, Brussels, Belgium;

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Nick Devoogdt

1MIMA, Department of Medical Imaging, Vrije Universiteit Brussel, Brussels, Belgium;

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Hendrik Everaert

2Nuclear Medicine Department, Universitair Ziekenhuis Brussel, Brussels, Belgium;

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Karine Breckpot

3Laboratory for Molecular and Cellular Therapy, Vrije Universiteit Brussel, Brussels, Belgium;

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Quentin Lecocq

3Laboratory for Molecular and Cellular Therapy, Vrije Universiteit Brussel, Brussels, Belgium;

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Lore Decoster

4Department of Medical Oncology, Universitair Ziekenhuis Brussel, Brussels, Belgium;

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Christel Fontaine

4Department of Medical Oncology, Universitair Ziekenhuis Brussel, Brussels, Belgium;

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Denis Schallier

4Department of Medical Oncology, Universitair Ziekenhuis Brussel, Brussels, Belgium;

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Sandrine Aspeslagh

4Department of Medical Oncology, Universitair Ziekenhuis Brussel, Brussels, Belgium;

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Ilse Vaneycken

2Nuclear Medicine Department, Universitair Ziekenhuis Brussel, Brussels, Belgium;

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Geert Raes

5Cellular and Molecular Immunology, Lab of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium; and

6Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium

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Jo A. Van Ginderachter

5Cellular and Molecular Immunology, Lab of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium; and

6Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium

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Tony Lahoutte

1MIMA, Department of Medical Imaging, Vrije Universiteit Brussel, Brussels, Belgium;

2Nuclear Medicine Department, Universitair Ziekenhuis Brussel, Brussels, Belgium;

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Vicky Caveliers

1MIMA, Department of Medical Imaging, Vrije Universiteit Brussel, Brussels, Belgium;

2Nuclear Medicine Department, Universitair Ziekenhuis Brussel, Brussels, Belgium;

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Marleen Keyaerts

1MIMA, Department of Medical Imaging, Vrije Universiteit Brussel, Brussels, Belgium;

2Nuclear Medicine Department, Universitair Ziekenhuis Brussel, Brussels, Belgium;

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Phase I Study of [⁶⁸Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)

Journal of Nuclear Medicine Sep 2023, 64 (9) 1378-1384; DOI: 10.2967/jnumed.122.264853

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Phase I Study of [⁶⁸Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)

Journal of Nuclear Medicine Sep 2023, 64 (9) 1378-1384; DOI: 10.2967/jnumed.122.264853

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Keywords

CD206
single-domain antibody
PET/CT
phase I
tumor-associated macrophages

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Phase I Study of [⁶⁸Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)

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