Article Figures & Data
Figures
- FIGURE 1.
CONSORT (consolidated standard of reporting trial) diagram demonstrating patient enrollment. SIRT = selective internal radiation therapy; TACE = transarterial chemoembolization.
- FIGURE 2.
ROC analyses of whole patient cohort assessing relationship of absorbed dose parameters and occurrence of liver decompensation within 6 mo.
- FIGURE 3.
Scatterplot of whole patient cohort: comparison of V40 between group of CTCAE for hyperbilirubinemia adverse effects ≥ 3 and group of CTCAE ≤ 2.
- FIGURE 4.
ROC analyses of patients undergoing partial-liver radioembolization assessing relationship of absorbed dose parameters and occurrence of liver decompensation within 6 mo.
- FIGURE 5.
ROC analyses of patients undergoing whole-liver radioembolization assessing relationship of absorbed dose parameters and occurrence of liver decompensation within 6 mo.
- FIGURE 6.
Scatterplot of whole-liver treatment patients: comparison of V40 between group of CTCAE for hyperbilirubinemia adverse effects ≥ 3 and group of CTCAE ≤ 2.
Tables
Characteristic Value Characteristic Value Age (y) 67.2 ± 10.1 (range, 20–86) ECOG score Sex 0 127 Male 142 1+ 46 Female 34 NA 3 Origin of cirrhosis Liver cirrhosis Alcohol 24 Positive 115 NASH 18 Negative 61 Hepatitis B 10 Tumor involvement Hepatitis C 22 <25% 147 Mixed or unknown 41 ≥25% 29 Baseline AST (IU/L) 61.2 ± 47.0 SIRT procedure Baseline ALT (IU/L) 51.4 ± 45.8 Partial-liver 78 Baseline bilirubin (mg/dL) 0.8 ± 0.4 Whole-liver 98 Baseline albumin (g/dL) 4.2 ± 0.4 PV thrombosis (//) Child–Pugh score Vp1–3 46 A 109 Vp4 9 B7 6 Negative 121 ALBI score Tumor invasiveness (positive/negative) G1 53 Positive 86 G2 122 Negative 90 G3 1 Treatment-native patients before SIRT 125 BCLC score Prior therapy* A 41 Liver resection 30 B 79 TACE or RFA 23 C 56 Sorafenib or lenvatinib 8 ↵* 10/51 patients underwent several prior therapies.
NASH = nonalcoholic steatohepatitis; AST = aspartate transaminase; ALT = alanine transaminase; ALBI = albumin-bilirubin; BCLC = Barcelona Clinic liver cancer; ECOG = Eastern Cooperative Oncology Group; NA = not applicable; SIRT = selective internal radiation therapy; PV = portal vein; tumor invasiveness = tumor with irregular margins invading into surrounding tissues including nontumor liver tissue, portal vein, or hepatic vein; TACE = transarterial chemoembolization; RFA = radiofrequency ablation.
Qualitative data are number and percentage; continuous data are mean ± SD.
- TABLE 2.
ROC Analysis of 6-Month Toxicity of Whole Patient Cohort with 6-Month Follow-up (CTCAE Grade 3+ Hyperbilirubinemia, 20 Positive and 156 Negative)
Parameter AD-WNTLT V20 V30 V40 AD-20 AD-30 AUC 0.672 0.768 0.782 0.790 0.765 0.770 P value 0.006 <0.001 <0.001 <0.001 <0.001 <0.001 P value vs AD-WNTLT* 0.025 0.0094 0.0046 0.096 0.055 Cutoff 56.9 Gy 80% 78% 68% 27 Gy 37 Gy ↵* P value of ROC comparison between each voxel-based parameter and AD-WNTLT (multicompartment parameter); cutoff was determined by Youden index.
- TABLE 3.
ROC Subanalysis of 6-Month Toxicity for Patients Who Underwent Partial Liver Treatment (CTCAE Grade 3+ Hyperbilirubinemia, 4 Positive and 74 Negative)
Parameter AD-WNTLT HR V20 V30 V40 AD-20 AD-30 AUC 0.578 0.591 0.534 0.546 0.542 0.520 0.588 P value 0.629 0.452 0.868 0.811 0.818 0.079 <0.001 P value vs AD-WNTLT* 0.90 0.41 0.45 0.30 0.72 0.95 Cutoff 58.7 Gy 33.8% 6% 6% 5% 0 Gy 0 Gy ↵* P value of ROC comparison between each voxel-based parameter and AD-WNTLT (multicompartment parameter); cutoff was determined by Youden index.
HR = hepatic reserve, that is, liver volume not treated by radioembolization.
- TABLE 4.
ROC Subanalysis of 6-Month Toxicity for Patients Who Underwent Whole Liver Treatment (CTCAE Grade 3+ Hyperbilirubinemia, 16 Positive and 82 Negative)
Parameter AD-WNTLT V20 V30 V40 AD-20 AD-30 AUC 0.633 0.796 0.824 0.840 0.803 0.823 P value 0.042 <0.001 <0.001 <0.001 <0.001 <0.001 P value vs AD-WNTLT* 0.032 0.0088 0.0038 0.041 0.015 Cutoff 55.6 Gy 80% 78% 72% 27 Gy 43 Gy ↵* P value of ROC comparison between each voxel-based parameter and AD-WNTLT (multicompartment parameter); cutoff was determined by Youden index.
Supplemental Data
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