Article Figures & Data
Figures
- FIGURE 1.
Flowchart of study patients.
- FIGURE 2.
Kaplan–Meier overall survival analysis stratified by MFR (<1.97 versus ≥1.97) and cancer stage (early versus advanced) in the overall cohort (n = 221).
Tables
Characteristic Data Characteristic Data Age (y) 71 (41–92) Vasodilator Age, binary Dipyridamole 93 (42.1%) <65 y 73 (33.0%) Regadenoson 128 (57.9%) ≥65 y 148 (67.0%) Heart rate (rest) 70.05 ± 13.15 Sex Heart rate (stress) 87.44 ± 16.56 (2*) Female 97 (43.9%) Rest systolic blood pressure 140.60 ± 20.55 Male 124 (56.1%) Stress systolic blood pressure 131.53 ± 22.53 (3*) Height (cm) 168 (132–193) Transient ischemic dilatation ratio 1.06 ± 0.15 (1*) Weight (kg) 79 (36–161) Stress MBF (mg/mL/min) 1.93 ± 0.74 Body mass index 27.82 (16.00–68.78) Rest MBF (mg/mL/min) 1.01 ± 0.42 Body mass index, binary Adjusted rest MBF (mg/mL/min) 0.88 ± 0.32 <30 136 (61.5%) MFR 2.04 ± 0.74 ≥30 85 (38.5%) Adjusted MFR 2.31 ± 0.85 Stress LVEF (%) 71 (18–90) (1*) Morise risk assessment Stress LVEF (%), binary 1* Low (0–8) 8 (3.6%) ≥50 198 (90.0%) Intermediate (9–15) 93 (42.1%) <50 22 (10.0%) High (>15) 120 (54.3%) Rest LVEF (%) 66 (21–90) (1*) SSS Rest LVEF (%), binary 1* Normal (0–3) 169 (76.5%) ≥50 194 (88.2%) Mild (4–7) 26 (11.8%) <50 26 (11.8%) Moderate (8–11) 8 (3.6%) LVEF reserve 5 (-22–21) (1*) Severe (≥12) 18 (8.1%) Abnormal LVEF reserve 1* Ischemia (SDS ≥ 3) Normal 196 (89.1%) Abnormal 46 (20.8%) Abnormal 24 (10.9%) Normal 175 (79.2%) Hemoglobin (g/dL) 12.40 (7.60–16.70) (4*) Coronary calcium (Agatston score) 5* Hemoglobin, binary 4* None/minimal (0–10) 47 (21.8%) ≥10 g/dL 189 (87.1%) Mild (11–100) 37 (17.1%) <10 g/dL 28 (12.9%) Moderate (101–400) 46 (21.3%) Diabetes Severe (>400) 68 (31.5%) No 143 (64.7%) Stent 9 (4.2%) Yes 78 (35.3%) Coronary artery bypass graft 9 (4.2%) Dyslipidemia 157 (71.0%) eGFR (mL/min/1.73 m2) 64 (22–109) Hypertension 172 (77.8%) eGFR, binary Smoker/former smoker 159 (71.9%) ≤60 96 (43.4%) History of CAD 82 (37.1%) >60 125 (56.6%) ↵* Unknown.
LVEF = left ventricular ejection fraction; MBF = myocardial blood flow; eGFR = estimated glomerular filtration rate.
Qualitative data are number and percentage; continuous data are median and range or mean ± SD.
Characteristic MFR ≥ 1.97, n = 111 MFR < 1.97, n = 110 P† Stress MBF (mg/mL/min) 2.14 (0.85–4.64) 1.57 (0.39–3.64) <0.001 Rest MBF (mg/mL/min) 0.81 (0.40–2.25) 1.01 (0.48–2.61) <0.001 Adjusted rest MBF (mg/mL/min) 0.77 (0.31–1.40) 0.88 (0.39–2.60) <0.001 Heart rate (stress) 87 (52–126) (2*) 84 (51–141) 0.33 Heart rate (rest) 66 (44–102) 71 (42–112) 0.006 Ejection fraction (stress, %) 73 (40–90) 67 (18–90) (1*) 0.002 Ejection fraction (rest, %) 67 (27–90) 64 (21–86) (1*) 0.084 SSS 0.0 (0.0–21.0) 1.0 (0.0–40.0) 0.003 SDS 0.0 (0.0–9.0) 0.0 (0.0–26.0) 0.021 Hemoglobin (g/dL) 12.85 (7.60–16.70) (1*) 11.80 (7.60–15.60) (3*) <0.001 Body mass index 28 (19–51) 27 (16–69) 0.26 Vasodilator 0.64 Dipyridamole 45 (41%) 48 (44%) Regadenoson 66 (59%) 62 (56%) History of CAD 29 (26%) 53 (48%) <0.001 Coronary calcium (Agatston score) (2*) (3*) <0.001 None/minimal (0–10) 32 (29%) 15 (14%) Mild (11–100) 25 (23%) 12 (11%) Moderate (101–400) 25 (23%) 21 (20%) Severe (>400) 25 (23%) 43 (40%) Stent 1 (1%) 8 (7%) Coronary artery bypass graft 1 (1%) 8 (7%) Age (y) 67 (44–92) 75 (41–90) <0.001
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