PET Imaging of Neutrophil Elastase with 11C-GW457427 in Acute Respiratory Distress Syndrome in Pigs

Emmi Puuvuori; Elena Chiodaroli; Sergio Estrada; Pierre Cheung; Norbert Lubenow; Jonathan Sigfridsson; Hampus Romelin; Sofie Ingvast; Mathias Elgland; Francesco Liggieri; Olle Korsgren; Gaetano Perchiazzi; Olof Eriksson; Gunnar Antoni

doi:10.2967/jnumed.122.264306

Research ArticleBasic Science Investigation

PET Imaging of Neutrophil Elastase with ¹¹C-GW457427 in Acute Respiratory Distress Syndrome in Pigs

Emmi Puuvuori, Elena Chiodaroli, Sergio Estrada, Pierre Cheung, Norbert Lubenow, Jonathan Sigfridsson, Hampus Romelin, Sofie Ingvast, Mathias Elgland, Francesco Liggieri, Olle Korsgren, Gaetano Perchiazzi, Olof Eriksson and Gunnar Antoni

Journal of Nuclear Medicine March 2023, 64 (3) 423-429; DOI: https://doi.org/10.2967/jnumed.122.264306

Emmi Puuvuori

1Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden;

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Elena Chiodaroli

2Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala Sweden;

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Sergio Estrada

1Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden;

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Pierre Cheung

1Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden;

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Norbert Lubenow

3Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden; and

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Jonathan Sigfridsson

4PET Center, Center for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden

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Hampus Romelin

4PET Center, Center for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden

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Sofie Ingvast

3Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden; and

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Mathias Elgland

1Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden;

4PET Center, Center for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden

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Francesco Liggieri

2Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala Sweden;

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Olle Korsgren

3Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden; and

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Gaetano Perchiazzi

2Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala Sweden;

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Olof Eriksson

1Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden;

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Gunnar Antoni

1Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden;

4PET Center, Center for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden

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Journal of Nuclear Medicine

Vol. 64, Issue 3

March 1, 2023

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PET Imaging of Neutrophil Elastase with ¹¹C-GW457427 in Acute Respiratory Distress Syndrome in Pigs

Journal of Nuclear Medicine Mar 2023, 64 (3) 423-429; DOI: 10.2967/jnumed.122.264306

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PET Imaging of Neutrophil Elastase with ¹¹C-GW457427 in Acute Respiratory Distress Syndrome in Pigs

Journal of Nuclear Medicine Mar 2023, 64 (3) 423-429; DOI: 10.2967/jnumed.122.264306

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Keywords

inflammation
PET
neutrophil elastase
ARDS

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