Longitudinal Tau PET Using 18F-Flortaucipir: The Effect of Relative Cerebral Blood Flow on Quantitative and Semiquantitative Parameters

Denise Visser; Hayel Tuncel; Rik Ossenkoppele; Maqsood Yaqub; Emma E. Wolters; Tessa Timmers; Emma Weltings; Emma M. Coomans; Marijke E. den Hollander; Wiesje M. van der Flier; Bart N.M. van Berckel; Sandeep S.V. Golla

doi:10.2967/jnumed.122.263926

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Longitudinal Tau PET Using ¹⁸F-Flortaucipir: The Effect of Relative Cerebral Blood Flow on Quantitative and Semiquantitative Parameters

Denise Visser, Hayel Tuncel, Rik Ossenkoppele, Maqsood Yaqub, Emma E. Wolters, Tessa Timmers, Emma Weltings, Emma M. Coomans, Marijke E. den Hollander, Wiesje M. van der Flier, Bart N.M. van Berckel and Sandeep S.V. Golla

Journal of Nuclear Medicine February 2023, 64 (2) 281-286; DOI: https://doi.org/10.2967/jnumed.122.263926

Denise Visser

1Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

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Hayel Tuncel

1Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

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Rik Ossenkoppele

2Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

3Clinical Memory Research Unit, Lund University, Lund, Sweden; and

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Maqsood Yaqub

1Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

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Emma E. Wolters

1Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

2Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

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Tessa Timmers

1Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

2Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

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Emma Weltings

1Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

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Emma M. Coomans

1Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

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Marijke E. den Hollander

1Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

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Wiesje M. van der Flier

2Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

4Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands

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Bart N.M. van Berckel

1Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

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Sandeep S.V. Golla

1Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands;

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February 1, 2023

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Longitudinal Tau PET Using ¹⁸F-Flortaucipir: The Effect of Relative Cerebral Blood Flow on Quantitative and Semiquantitative Parameters

Journal of Nuclear Medicine Feb 2023, 64 (2) 281-286; DOI: 10.2967/jnumed.122.263926

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Longitudinal Tau PET Using ¹⁸F-Flortaucipir: The Effect of Relative Cerebral Blood Flow on Quantitative and Semiquantitative Parameters

Journal of Nuclear Medicine Feb 2023, 64 (2) 281-286; DOI: 10.2967/jnumed.122.263926

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Keywords

Alzheimer disease
dynamic (DVR/BPND)
longitudinal 18F-flortaucipir PET
quantification
static (SUVr)

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Longitudinal Tau PET Using ¹⁸F-Flortaucipir: The Effect of Relative Cerebral Blood Flow on Quantitative and Semiquantitative Parameters

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