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Research ArticleFocus on Molecular Imaging

The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection

Signore Alberto, Alvaro A. Ordonez, Chanda Arjun, Gurpreet Kaur Aulakh, Nicolas Beziere, Ekaterina Dadachova, Thomas Ebenhan, Ulises Granados, Aruna Korde, Amirreza Jalilian, Wening Lestari, Archana Mukherjee, Milos Petrik, Tamer Sakr, Clara L. Santos Cuevas, Mick M. Welling, Jan Rijn Zeevaart, Sanjay K. Jain and David M. Wilson
Journal of Nuclear Medicine November 2023, 64 (11) 1676-1682; DOI: https://doi.org/10.2967/jnumed.123.265906
Signore Alberto
1Nuclear Medicine Unit, Department of Medical-Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, University of Rome “Sapienza,” Rome, Italy;
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Alvaro A. Ordonez
2Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland;
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Chanda Arjun
3Radiopharmaceutical Program, Board of Radiation and Isotope Technology, Mumbai, India;
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Gurpreet Kaur Aulakh
4Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;
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Nicolas Beziere
5Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tübingen, Tübingen, Germany;
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Ekaterina Dadachova
6College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;
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Thomas Ebenhan
7Nuclear Medicine, University of Pretoria, and Radiochemistry, Applied Radiation, South African Nuclear Energy Corporation, Pelindaba, South Africa;
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Ulises Granados
8Department of Nuclear Medicine, Hospital Internacional de Colombia–Fundación Cardiovascular de Colombia, Piedecuesta, Colombia;
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Aruna Korde
9Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria;
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Amirreza Jalilian
9Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria;
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Wening Lestari
10National Nuclear Energy Agency, South Tangerang, Indonesia;
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Archana Mukherjee
11Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India;
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Milos Petrik
12Institute of Molecular and Translational Medicine and Czech Advanced Technology and Research Institute, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic;
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Tamer Sakr
13Radioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, Egypt;
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Clara L. Santos Cuevas
14Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Mexico;
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Mick M. Welling
15Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; and
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Jan Rijn Zeevaart
7Nuclear Medicine, University of Pretoria, and Radiochemistry, Applied Radiation, South African Nuclear Energy Corporation, Pelindaba, South Africa;
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Sanjay K. Jain
2Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland;
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David M. Wilson
16Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California
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Abstract

The International Atomic Energy Agency organized a technical meeting at its headquarters in Vienna, Austria, in 2022 that included 17 experts representing 12 countries, whose research spanned the development and use of radiolabeled agents for imaging infection. The meeting focused largely on bacterial pathogens. The group discussed and evaluated the advantages and disadvantages of several radiopharmaceuticals, as well as the science driving various imaging approaches. The main objective was to understand why few infection-targeted radiotracers are used in clinical practice despite the urgent need to better characterize bacterial infections. This article summarizes the resulting consensus, at least among the included scientists and countries, on the current status of radiopharmaceutical development for infection imaging. Also included are opinions and recommendations regarding current research standards in this area. This and future International Atomic Energy Agency–sponsored collaborations will advance the goal of providing the medical community with innovative, practical tools for the specific image-based diagnosis of infection.

  • infection
  • antibiotics
  • radiotracer
  • molecular imaging
  • development

Footnotes

  • ↵* Contributed equally to this work.

  • Published online Sep. 28, 2023.

  • © 2023 by the Society of Nuclear Medicine and Molecular Imaging.
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Journal of Nuclear Medicine: 64 (11)
Journal of Nuclear Medicine
Vol. 64, Issue 11
November 1, 2023
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The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection
Signore Alberto, Alvaro A. Ordonez, Chanda Arjun, Gurpreet Kaur Aulakh, Nicolas Beziere, Ekaterina Dadachova, Thomas Ebenhan, Ulises Granados, Aruna Korde, Amirreza Jalilian, Wening Lestari, Archana Mukherjee, Milos Petrik, Tamer Sakr, Clara L. Santos Cuevas, Mick M. Welling, Jan Rijn Zeevaart, Sanjay K. Jain, David M. Wilson
Journal of Nuclear Medicine Nov 2023, 64 (11) 1676-1682; DOI: 10.2967/jnumed.123.265906

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The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection
Signore Alberto, Alvaro A. Ordonez, Chanda Arjun, Gurpreet Kaur Aulakh, Nicolas Beziere, Ekaterina Dadachova, Thomas Ebenhan, Ulises Granados, Aruna Korde, Amirreza Jalilian, Wening Lestari, Archana Mukherjee, Milos Petrik, Tamer Sakr, Clara L. Santos Cuevas, Mick M. Welling, Jan Rijn Zeevaart, Sanjay K. Jain, David M. Wilson
Journal of Nuclear Medicine Nov 2023, 64 (11) 1676-1682; DOI: 10.2967/jnumed.123.265906
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Keywords

  • infection
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