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Research ArticleBasic Science Investigation
Open Access

Interrogating Glioma-Associated Microglia and Macrophage Dynamics Under CSF-1R Therapy with Multitracer In Vivo PET/MRI

Claudia Foray, Cristina Barca, Alexandra Winkeler, Stefan Wagner, Sven Hermann, Michael Schäfers, Oliver M. Grauer, Bastian Zinnhardt and Andreas H. Jacobs
Journal of Nuclear Medicine September 2022, 63 (9) 1386-1393; DOI: https://doi.org/10.2967/jnumed.121.263318
Claudia Foray
1European Institute for Molecular Imaging, University of Münster, Münster, Germany;
2PET Imaging in Drug Design and Development, Münster, Germany;
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Cristina Barca
1European Institute for Molecular Imaging, University of Münster, Münster, Germany;
2PET Imaging in Drug Design and Development, Münster, Germany;
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Alexandra Winkeler
3Université Paris-Saclay, BioMaps, CEA, CNRS, INSERM, Orsay, France;
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Stefan Wagner
4Department of Nuclear Medicine, University Hospital Münster, Münster, Germany;
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Sven Hermann
1European Institute for Molecular Imaging, University of Münster, Münster, Germany;
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Michael Schäfers
1European Institute for Molecular Imaging, University of Münster, Münster, Germany;
4Department of Nuclear Medicine, University Hospital Münster, Münster, Germany;
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Oliver M. Grauer
5Department of Neurology, University Hospital Münster, Münster, Germany;
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Bastian Zinnhardt
1European Institute for Molecular Imaging, University of Münster, Münster, Germany;
2PET Imaging in Drug Design and Development, Münster, Germany;
4Department of Nuclear Medicine, University Hospital Münster, Münster, Germany;
6Biomarkers and Translational Technologies, Neurosciences and Rare Diseases, Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland; and
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Andreas H. Jacobs
1European Institute for Molecular Imaging, University of Münster, Münster, Germany;
2PET Imaging in Drug Design and Development, Münster, Germany;
7Department of Geriatrics with Neurology, Johanniter Hospital, and Centre for Integrated Oncology of the University Hospital Bonn, Bonn, Germany
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Article Information

vol. 63 no. 9 1386-1393
DOI 
https://doi.org/10.2967/jnumed.121.263318
PubMed 
35115369

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication October 6, 2021
  • Revision received January 4, 2022
  • Published online September 1, 2022.

Article Versions

  • previous version (February 3, 2022 - 11:45).
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Copyright & Usage 
© 2022 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Claudia Foray*,1,2,
  2. Cristina Barca*,1,2,
  3. Alexandra Winkeler3,
  4. Stefan Wagner4,
  5. Sven Hermann1,
  6. Michael Schäfers1,4,
  7. Oliver M. Grauer†,5,
  8. Bastian Zinnhardt†,1,2,4,6 and
  9. Andreas H. Jacobs†,1,2,7
  1. 1European Institute for Molecular Imaging, University of Münster, Münster, Germany;
  2. 2PET Imaging in Drug Design and Development, Münster, Germany;
  3. 3Université Paris-Saclay, BioMaps, CEA, CNRS, INSERM, Orsay, France;
  4. 4Department of Nuclear Medicine, University Hospital Münster, Münster, Germany;
  5. 5Department of Neurology, University Hospital Münster, Münster, Germany;
  6. 6Biomarkers and Translational Technologies, Neurosciences and Rare Diseases, Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland; and
  7. 7Department of Geriatrics with Neurology, Johanniter Hospital, and Centre for Integrated Oncology of the University Hospital Bonn, Bonn, Germany
  1. For correspondence or reprints, contact Andreas H. Jacobs (ahjacobs{at}uni-muenster.de) or Claudia Foray (claudia.foray{at}uni-muenster.de).
  1. ↵* Contributed equally to this work.

  2. ↵† Contributed equally to this work.

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Journal of Nuclear Medicine: 63 (9)
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September 1, 2022
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Interrogating Glioma-Associated Microglia and Macrophage Dynamics Under CSF-1R Therapy with Multitracer In Vivo PET/MRI
Claudia Foray, Cristina Barca, Alexandra Winkeler, Stefan Wagner, Sven Hermann, Michael Schäfers, Oliver M. Grauer, Bastian Zinnhardt, Andreas H. Jacobs
Journal of Nuclear Medicine Sep 2022, 63 (9) 1386-1393; DOI: 10.2967/jnumed.121.263318

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Interrogating Glioma-Associated Microglia and Macrophage Dynamics Under CSF-1R Therapy with Multitracer In Vivo PET/MRI
Claudia Foray, Cristina Barca, Alexandra Winkeler, Stefan Wagner, Sven Hermann, Michael Schäfers, Oliver M. Grauer, Bastian Zinnhardt, Andreas H. Jacobs
Journal of Nuclear Medicine Sep 2022, 63 (9) 1386-1393; DOI: 10.2967/jnumed.121.263318
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Keywords

  • glioma
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  • CSF-1R
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