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Research ArticleSpecial Contribution

A Path to Qualification of PET/MRI Scanners for Multicenter Brain Imaging Studies: Evaluation of MRI-Based Attenuation Correction Methods Using a Patient Phantom

Ciprian Catana, Richard Laforest, Hongyu An, Fernando Boada, Tuoyu Cao, David Faul, Bjoern Jakoby, Floris P. Jansen, Bradley J. Kemp, Paul E. Kinahan, Peder Larson, Michael A. Levine, Piotr Maniawski, Osama Mawlawi, Jonathan E. McConathy, Alan B. McMillan, Julie C. Price, Abhejit Rajagopal, John Sunderland, Patrick Veit-Haibach, Kristen A. Wangerin, Chunwei Ying and Thomas A. Hope
Journal of Nuclear Medicine April 2022, 63 (4) 615-621; DOI: https://doi.org/10.2967/jnumed.120.261881
Ciprian Catana
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts;
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Richard Laforest
2Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri;
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Hongyu An
2Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri;
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Fernando Boada
3Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University Langone Medical Center, New York, New York;
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Tuoyu Cao
4Shanghai United Imaging Healthcare Co., Ltd., Shanghai, China;
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David Faul
5Siemens Medical Solutions USA, Inc., Malvern, Pennsylvania;
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Bjoern Jakoby
6Siemens MR, Siemens Healthcare GmbH, Erlangen, Germany;
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Floris P. Jansen
7PET/MR Engineering, GE Healthcare, Chicago, Illinois;
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Bradley J. Kemp
8Division of Nuclear Medicine, Mayo Clinic, Rochester, Minnesota;
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Paul E. Kinahan
9Imaging Research Laboratory, University of Washington, Seattle, Washington;
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Peder Larson
10Department of Radiology and Biomedical Imaging, University of California, San Francisco, California;
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Michael A. Levine
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts;
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Piotr Maniawski
11Advanced Molecular Imaging, Philips Healthcare, Cleveland, Ohio;
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Osama Mawlawi
12Department of Imaging Physics, University of Texas M.D. Anderson Cancer Center, Houston, Texas;
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Jonathan E. McConathy
13Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama;
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Alan B. McMillan
14Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;
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Julie C. Price
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts;
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Abhejit Rajagopal
10Department of Radiology and Biomedical Imaging, University of California, San Francisco, California;
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John Sunderland
15Division of Nuclear Medicine, Department of Radiology, University of Iowa, Iowa City, Iowa;
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Patrick Veit-Haibach
16Toronto Joint Department of Medical Imaging, University Health Network, Sinai Health System, and Women’s College Hospital, Department of Medical Imaging, University of Toronto, Toronto, Canada;
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Kristen A. Wangerin
17GE Healthcare, Chicago, Illinois; and
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Chunwei Ying
18Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri
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Thomas A. Hope
10Department of Radiology and Biomedical Imaging, University of California, San Francisco, California;
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  • FIGURE 1.
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    FIGURE 1.

    Attenuation maps and corresponding 18F-AV-45 PET images for 2 representative subjects. No artifacts or obvious misregistration can be observed (QC 1).

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    FIGURE 2.

    Cumulative voxelwise relative differences between PET images obtained using 4 attenuation map generation methods and those generated using reference CT-based approach for 2 representative subjects (blue). Voxelwise relative differences are below 10% in at least 90% of voxels included in brain masks for Siemens skull model-based and GE ZTE-based approaches (QC 2). Percentage of voxels with absolute relative difference smaller than 10% is indicated in each case. Green line represents histogram of pixelwise percentage difference.

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    FIGURE 3.

    Bland–Altman plots of absolute relative differences between PET images obtained using 4 attenuation map generation methods and those generated using reference CT-based approach for study-specific FreeSurfer-based ROIs for 2 representative subjects. Average absolute percentage differences are below 10% in all study-specific ROIs for Siemens skull model-based and GE ZTE-based approaches (QC 3). CTAC = CT-based AC.

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    FIGURE 4.

    Cumulative voxelwise relative differences between PET images obtained using MRI-based methods with respect to CT-based approach for all 10 subjects analyzed. Solid curve represents mean across 5 subjects for each method. Voxelwise relative differences are below 10% in at least 90% of voxels included in brain masks for all subjects when using Siemens skull model-based and GE ZTE-based approaches.

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Journal of Nuclear Medicine: 63 (4)
Journal of Nuclear Medicine
Vol. 63, Issue 4
April 1, 2022
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A Path to Qualification of PET/MRI Scanners for Multicenter Brain Imaging Studies: Evaluation of MRI-Based Attenuation Correction Methods Using a Patient Phantom
Ciprian Catana, Richard Laforest, Hongyu An, Fernando Boada, Tuoyu Cao, David Faul, Bjoern Jakoby, Floris P. Jansen, Bradley J. Kemp, Paul E. Kinahan, Peder Larson, Michael A. Levine, Piotr Maniawski, Osama Mawlawi, Jonathan E. McConathy, Alan B. McMillan, Julie C. Price, Abhejit Rajagopal, John Sunderland, Patrick Veit-Haibach, Kristen A. Wangerin, Chunwei Ying, Thomas A. Hope
Journal of Nuclear Medicine Apr 2022, 63 (4) 615-621; DOI: 10.2967/jnumed.120.261881

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A Path to Qualification of PET/MRI Scanners for Multicenter Brain Imaging Studies: Evaluation of MRI-Based Attenuation Correction Methods Using a Patient Phantom
Ciprian Catana, Richard Laforest, Hongyu An, Fernando Boada, Tuoyu Cao, David Faul, Bjoern Jakoby, Floris P. Jansen, Bradley J. Kemp, Paul E. Kinahan, Peder Larson, Michael A. Levine, Piotr Maniawski, Osama Mawlawi, Jonathan E. McConathy, Alan B. McMillan, Julie C. Price, Abhejit Rajagopal, John Sunderland, Patrick Veit-Haibach, Kristen A. Wangerin, Chunwei Ying, Thomas A. Hope
Journal of Nuclear Medicine Apr 2022, 63 (4) 615-621; DOI: 10.2967/jnumed.120.261881
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  • Article
    • Visual Abstract
    • Abstract
    • ACCREDITATION AND QUALIFICATION
    • APPROACHES USED IN PET/CT
    • PROPOSED SOLUTION FOR PET/MRI SCANNERS: QUALIFICATION USING HUMAN PHANTOMS
    • EXAMPLE APPLICATION
    • DISCUSSION
    • CONCLUSION
    • DISCLOSURE
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Keywords

  • PET/MRI
  • attenuation correction
  • multicenter trials
  • qualification
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