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Research ArticleBasic Science Investigation

Evaluation of (rac)-, (R)-, and (S)-18F-OF-NB1 for Imaging GluN2B Subunit–Containing N-Methyl-d-Aspartate Receptors in Nonhuman Primates

Hazem Ahmed, Ming-Qiang Zheng, Kelly Smart, Hanyi Fang, Li Zhang, Paul R. Emery, Hong Gao, Jim Ropchan, Achi Haider, Gilles Tamagnan, Richard E. Carson, Simon M. Ametamey and Yiyun Huang
Journal of Nuclear Medicine December 2022, 63 (12) 1912-1918; DOI: https://doi.org/10.2967/jnumed.122.263977
Hazem Ahmed
1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland;
2PET Center, Yale University, New Haven, Connecticut; and
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Ming-Qiang Zheng
2PET Center, Yale University, New Haven, Connecticut; and
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Kelly Smart
2PET Center, Yale University, New Haven, Connecticut; and
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Hanyi Fang
2PET Center, Yale University, New Haven, Connecticut; and
3Union Hospital, Huazhong University of Science and Technology, Wuhan, China
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Li Zhang
2PET Center, Yale University, New Haven, Connecticut; and
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Paul R. Emery
2PET Center, Yale University, New Haven, Connecticut; and
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Hong Gao
2PET Center, Yale University, New Haven, Connecticut; and
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Jim Ropchan
2PET Center, Yale University, New Haven, Connecticut; and
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Achi Haider
1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland;
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Gilles Tamagnan
2PET Center, Yale University, New Haven, Connecticut; and
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Richard E. Carson
2PET Center, Yale University, New Haven, Connecticut; and
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Simon M. Ametamey
1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland;
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Yiyun Huang
2PET Center, Yale University, New Haven, Connecticut; and
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Article Information

vol. 63 no. 12 1912-1918
DOI 
https://doi.org/10.2967/jnumed.122.263977
PubMed 
35710735

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication February 7, 2022
  • Revision received April 7, 2022
  • Published online December 1, 2022.

Article Versions

  • previous version (June 16, 2022 - 11:06).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2022 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Hazem Ahmed*,1,2,
  2. Ming-Qiang Zheng*,2,
  3. Kelly Smart2,
  4. Hanyi Fang2,3,
  5. Li Zhang2,
  6. Paul R. Emery2,
  7. Hong Gao2,
  8. Jim Ropchan2,
  9. Achi Haider1,
  10. Gilles Tamagnan2,
  11. Richard E. Carson2,
  12. Simon M. Ametamey1 and
  13. Yiyun Huang2
  1. 1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland;
  2. 2PET Center, Yale University, New Haven, Connecticut; and
  3. 3Union Hospital, Huazhong University of Science and Technology, Wuhan, China
  1. For correspondence or reprints, contact Yiyun Henry Huang (henry.huang{at}yale.edu) or Simon M. Ametamey (simon.ametamey{at}pharma.ethz.ch).
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 63 (12)
Journal of Nuclear Medicine
Vol. 63, Issue 12
December 1, 2022
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Evaluation of (rac)-, (R)-, and (S)-18F-OF-NB1 for Imaging GluN2B Subunit–Containing N-Methyl-d-Aspartate Receptors in Nonhuman Primates
Hazem Ahmed, Ming-Qiang Zheng, Kelly Smart, Hanyi Fang, Li Zhang, Paul R. Emery, Hong Gao, Jim Ropchan, Achi Haider, Gilles Tamagnan, Richard E. Carson, Simon M. Ametamey, Yiyun Huang
Journal of Nuclear Medicine Dec 2022, 63 (12) 1912-1918; DOI: 10.2967/jnumed.122.263977

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Evaluation of (rac)-, (R)-, and (S)-18F-OF-NB1 for Imaging GluN2B Subunit–Containing N-Methyl-d-Aspartate Receptors in Nonhuman Primates
Hazem Ahmed, Ming-Qiang Zheng, Kelly Smart, Hanyi Fang, Li Zhang, Paul R. Emery, Hong Gao, Jim Ropchan, Achi Haider, Gilles Tamagnan, Richard E. Carson, Simon M. Ametamey, Yiyun Huang
Journal of Nuclear Medicine Dec 2022, 63 (12) 1912-1918; DOI: 10.2967/jnumed.122.263977
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Keywords

  • NMDA
  • GluN2B subunit
  • brain PET imaging
  • nonhuman primates
  • neurodegeneration
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