Research ArticleClinical Investigation
First-in-Humans PET Imaging of Tissue Factor in Patients with Primary and Metastatic Cancers Using 18F-labeled Active-Site Inhibited Factor VII (18F-ASIS): Potential as Companion Diagnostic
Mathias Loft, Camilla Christensen, Malene M. Clausen, Esben A. Carlsen, Carsten P. Hansen, Niels Kroman, Seppo W. Langer, Claus Høgdall, Jacob Madsen, Nic Gillings, Carsten H. Nielsen, Thomas L. Klausen, Søren Holm, Annika Loft, Anne K. Berthelsen and Andreas Kjaer
Journal of Nuclear Medicine December 2022, 63 (12) 1871-1879; DOI: https://doi.org/10.2967/jnumed.122.264068
Mathias Loft
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
Camilla Christensen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
Malene M. Clausen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
2Department of Oncology, Copenhagen University Hospital – Rigshospitalet, Denmark;
Esben A. Carlsen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
Carsten P. Hansen
3Department of Surgery, Copenhagen University Hospital – Rigshospitalet, Denmark;
Niels Kroman
4Department of Breast Surgery, Copenhagen University Hospital – Rigshospitalet, Denmark;
Seppo W. Langer
2Department of Oncology, Copenhagen University Hospital – Rigshospitalet, Denmark;
5Department of Clinical Medicine, University of Copenhagen, Denmark;
Claus Høgdall
6Department of Gynecology, Copenhagen University Hospital – Rigshospitalet, Denmark and
Jacob Madsen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
Nic Gillings
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
Carsten H. Nielsen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
7Minerva Imaging ApS, Denmark
Thomas L. Klausen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
Søren Holm
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
Annika Loft
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
Anne K. Berthelsen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
Andreas Kjaer
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;

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In this issue
Journal of Nuclear Medicine
Vol. 63, Issue 12
December 1, 2022
First-in-Humans PET Imaging of Tissue Factor in Patients with Primary and Metastatic Cancers Using 18F-labeled Active-Site Inhibited Factor VII (18F-ASIS): Potential as Companion Diagnostic
Mathias Loft, Camilla Christensen, Malene M. Clausen, Esben A. Carlsen, Carsten P. Hansen, Niels Kroman, Seppo W. Langer, Claus Høgdall, Jacob Madsen, Nic Gillings, Carsten H. Nielsen, Thomas L. Klausen, Søren Holm, Annika Loft, Anne K. Berthelsen, Andreas Kjaer
Journal of Nuclear Medicine Dec 2022, 63 (12) 1871-1879; DOI: 10.2967/jnumed.122.264068
First-in-Humans PET Imaging of Tissue Factor in Patients with Primary and Metastatic Cancers Using 18F-labeled Active-Site Inhibited Factor VII (18F-ASIS): Potential as Companion Diagnostic
Mathias Loft, Camilla Christensen, Malene M. Clausen, Esben A. Carlsen, Carsten P. Hansen, Niels Kroman, Seppo W. Langer, Claus Høgdall, Jacob Madsen, Nic Gillings, Carsten H. Nielsen, Thomas L. Klausen, Søren Holm, Annika Loft, Anne K. Berthelsen, Andreas Kjaer
Journal of Nuclear Medicine Dec 2022, 63 (12) 1871-1879; DOI: 10.2967/jnumed.122.264068
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