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Research ArticleClinical Investigation

First-in-Humans PET Imaging of Tissue Factor in Patients with Primary and Metastatic Cancers Using 18F-labeled Active-Site Inhibited Factor VII (18F-ASIS): Potential as Companion Diagnostic

Mathias Loft, Camilla Christensen, Malene M. Clausen, Esben A. Carlsen, Carsten P. Hansen, Niels Kroman, Seppo W. Langer, Claus Høgdall, Jacob Madsen, Nic Gillings, Carsten H. Nielsen, Thomas L. Klausen, Søren Holm, Annika Loft, Anne K. Berthelsen and Andreas Kjaer
Journal of Nuclear Medicine December 2022, 63 (12) 1871-1879; DOI: https://doi.org/10.2967/jnumed.122.264068
Mathias Loft
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
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Camilla Christensen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
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Malene M. Clausen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
2Department of Oncology, Copenhagen University Hospital – Rigshospitalet, Denmark;
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Esben A. Carlsen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
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Carsten P. Hansen
3Department of Surgery, Copenhagen University Hospital – Rigshospitalet, Denmark;
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Niels Kroman
4Department of Breast Surgery, Copenhagen University Hospital – Rigshospitalet, Denmark;
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Seppo W. Langer
2Department of Oncology, Copenhagen University Hospital – Rigshospitalet, Denmark;
5Department of Clinical Medicine, University of Copenhagen, Denmark;
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Claus Høgdall
6Department of Gynecology, Copenhagen University Hospital – Rigshospitalet, Denmark and
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Jacob Madsen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
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Nic Gillings
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
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Carsten H. Nielsen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
7Minerva Imaging ApS, Denmark
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Thomas L. Klausen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
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Søren Holm
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
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Annika Loft
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
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Anne K. Berthelsen
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
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Andreas Kjaer
1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
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Article Information

vol. 63 no. 12 1871-1879
DOI 
https://doi.org/10.2967/jnumed.122.264068
PubMed 
35589407

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication March 4, 2022
  • Revision received May 10, 2022
  • Published online December 1, 2022.

Article Versions

  • previous version (May 19, 2022 - 13:06).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2022 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Mathias Loft1,
  2. Camilla Christensen1,
  3. Malene M. Clausen1,2,
  4. Esben A. Carlsen1,
  5. Carsten P. Hansen3,
  6. Niels Kroman4,
  7. Seppo W. Langer2,5,
  8. Claus Høgdall6,
  9. Jacob Madsen1,
  10. Nic Gillings1,
  11. Carsten H. Nielsen1,7,
  12. Thomas L. Klausen1,
  13. Søren Holm1,
  14. Annika Loft1,
  15. Anne K. Berthelsen1 and
  16. Andreas Kjaer1
  1. 1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark;
  2. 2Department of Oncology, Copenhagen University Hospital – Rigshospitalet, Denmark;
  3. 3Department of Surgery, Copenhagen University Hospital – Rigshospitalet, Denmark;
  4. 4Department of Breast Surgery, Copenhagen University Hospital – Rigshospitalet, Denmark;
  5. 5Department of Clinical Medicine, University of Copenhagen, Denmark;
  6. 6Department of Gynecology, Copenhagen University Hospital – Rigshospitalet, Denmark and
  7. 7Minerva Imaging ApS, Denmark
  1. For correspondence or reprints, contact Andreas Kjaer (akjaer{at}sund.ku.dk).
  1. * Contributed equally to this work.

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Journal of Nuclear Medicine: 63 (12)
Journal of Nuclear Medicine
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First-in-Humans PET Imaging of Tissue Factor in Patients with Primary and Metastatic Cancers Using 18F-labeled Active-Site Inhibited Factor VII (18F-ASIS): Potential as Companion Diagnostic
Mathias Loft, Camilla Christensen, Malene M. Clausen, Esben A. Carlsen, Carsten P. Hansen, Niels Kroman, Seppo W. Langer, Claus Høgdall, Jacob Madsen, Nic Gillings, Carsten H. Nielsen, Thomas L. Klausen, Søren Holm, Annika Loft, Anne K. Berthelsen, Andreas Kjaer
Journal of Nuclear Medicine Dec 2022, 63 (12) 1871-1879; DOI: 10.2967/jnumed.122.264068

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First-in-Humans PET Imaging of Tissue Factor in Patients with Primary and Metastatic Cancers Using 18F-labeled Active-Site Inhibited Factor VII (18F-ASIS): Potential as Companion Diagnostic
Mathias Loft, Camilla Christensen, Malene M. Clausen, Esben A. Carlsen, Carsten P. Hansen, Niels Kroman, Seppo W. Langer, Claus Høgdall, Jacob Madsen, Nic Gillings, Carsten H. Nielsen, Thomas L. Klausen, Søren Holm, Annika Loft, Anne K. Berthelsen, Andreas Kjaer
Journal of Nuclear Medicine Dec 2022, 63 (12) 1871-1879; DOI: 10.2967/jnumed.122.264068
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Keywords

  • Active site inhibited factor VII (ASIS)
  • Tissue Factor
  • PET/CT
  • first-in-humans
  • Phase I clinical trial
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