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Research ArticleBasic Science Investigation
Open Access

Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease

Gloria Biechele, Laura Sebastian Monasor, Karin Wind, Tanja Blume, Samira Parhizkar, Thomas Arzberger, Christian Sacher, Leonie Beyer, Florian Eckenweber, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Michael Willem, Peter Bartenstein, Paul Cumming, Axel Rominger, Jochen Herms, Stefan F. Lichtenthaler, Christian Haass, Sabina Tahirovic and Matthias Brendel
Journal of Nuclear Medicine January 2022, 63 (1) 117-124; DOI: https://doi.org/10.2967/jnumed.120.261858
Gloria Biechele
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany;
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Laura Sebastian Monasor
2German Center for Neurodegenerative Diseases Munich, Munich, Germany;
3Graduate School of Systemic Neuroscience, Ludwig-Maximilians-University Munich, Munich, Germany;
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Karin Wind
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany;
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Tanja Blume
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany;
2German Center for Neurodegenerative Diseases Munich, Munich, Germany;
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Samira Parhizkar
4Department of Neurology, Washington University, St. Louis, Missouri;
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Thomas Arzberger
2German Center for Neurodegenerative Diseases Munich, Munich, Germany;
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Christian Sacher
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany;
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Leonie Beyer
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany;
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Florian Eckenweber
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany;
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Franz-Josef Gildehaus
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany;
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Barbara von Ungern-Sternberg
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany;
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Michael Willem
5Chair of Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, LMU Munich, Munich, Germany;
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Peter Bartenstein
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany;
6Munich Cluster for Systems Neurology, Munich, Germany;
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Paul Cumming
7Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland;
8School of Psychology and Counselling and IHBI, Queensland University of Technology, Brisbane, Australia;
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Axel Rominger
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany;
7Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland;
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Jochen Herms
2German Center for Neurodegenerative Diseases Munich, Munich, Germany;
6Munich Cluster for Systems Neurology, Munich, Germany;
9Center of Neuropathology and Prion Research, University of Munich, Munich, Germany; and
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Stefan F. Lichtenthaler
2German Center for Neurodegenerative Diseases Munich, Munich, Germany;
6Munich Cluster for Systems Neurology, Munich, Germany;
10Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
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Christian Haass
2German Center for Neurodegenerative Diseases Munich, Munich, Germany;
5Chair of Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, LMU Munich, Munich, Germany;
6Munich Cluster for Systems Neurology, Munich, Germany;
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Sabina Tahirovic
2German Center for Neurodegenerative Diseases Munich, Munich, Germany;
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Matthias Brendel
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany;
6Munich Cluster for Systems Neurology, Munich, Germany;
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Article Information

vol. 63 no. 1 117-124
DOI 
https://doi.org/10.2967/jnumed.120.261858
PubMed 
34016733

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication December 18, 2020
  • Revision received April 13, 2021
  • Published online January 3, 2022.

Article Versions

  • previous version (May 20, 2021 - 12:13).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2022 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Gloria Biechele*,1,
  2. Laura Sebastian Monasor*,2,3,
  3. Karin Wind1,
  4. Tanja Blume1,2,
  5. Samira Parhizkar4,
  6. Thomas Arzberger2,
  7. Christian Sacher1,
  8. Leonie Beyer1,
  9. Florian Eckenweber1,
  10. Franz-Josef Gildehaus1,
  11. Barbara von Ungern-Sternberg1,
  12. Michael Willem5,
  13. Peter Bartenstein1,6,
  14. Paul Cumming7,8,
  15. Axel Rominger1,7,
  16. Jochen Herms2,6,9,
  17. Stefan F. Lichtenthaler2,6,10,
  18. Christian Haass2,5,6,
  19. Sabina Tahirovic*,2 and
  20. Matthias Brendel*,1,6
  1. 1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany;
  2. 2German Center for Neurodegenerative Diseases Munich, Munich, Germany;
  3. 3Graduate School of Systemic Neuroscience, Ludwig-Maximilians-University Munich, Munich, Germany;
  4. 4Department of Neurology, Washington University, St. Louis, Missouri;
  5. 5Chair of Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, LMU Munich, Munich, Germany;
  6. 6Munich Cluster for Systems Neurology, Munich, Germany;
  7. 7Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland;
  8. 8School of Psychology and Counselling and IHBI, Queensland University of Technology, Brisbane, Australia;
  9. 9Center of Neuropathology and Prion Research, University of Munich, Munich, Germany; and
  10. 10Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
  1. For correspondence or reprints, contact Matthias Brendel (matthias.brendel{at}med.uni-muenchen.de).
  1. ↵*Contributed equally to this work.

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Journal of Nuclear Medicine: 63 (1)
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Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease
Gloria Biechele, Laura Sebastian Monasor, Karin Wind, Tanja Blume, Samira Parhizkar, Thomas Arzberger, Christian Sacher, Leonie Beyer, Florian Eckenweber, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Michael Willem, Peter Bartenstein, Paul Cumming, Axel Rominger, Jochen Herms, Stefan F. Lichtenthaler, Christian Haass, Sabina Tahirovic, Matthias Brendel
Journal of Nuclear Medicine Jan 2022, 63 (1) 117-124; DOI: 10.2967/jnumed.120.261858

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Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease
Gloria Biechele, Laura Sebastian Monasor, Karin Wind, Tanja Blume, Samira Parhizkar, Thomas Arzberger, Christian Sacher, Leonie Beyer, Florian Eckenweber, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Michael Willem, Peter Bartenstein, Paul Cumming, Axel Rominger, Jochen Herms, Stefan F. Lichtenthaler, Christian Haass, Sabina Tahirovic, Matthias Brendel
Journal of Nuclear Medicine Jan 2022, 63 (1) 117-124; DOI: 10.2967/jnumed.120.261858
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Keywords

  • amyloid
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