Article Figures & Data
Figures
- FIGURE 1.
18F-flortaucipir (18F-FTP) and 18F-MK-6240 SUVR images from 6 subjects representing the range of tau pathology observed in our cohort. From left to right: subject showing no evidence of tau pathology (NC7); cognitively normal subject showing early Braak stage pathology (NC4); atypical AD subject with tau pathology in MTL and evidence of focal uptake in Braak V (AD1); and 3 AD subjects showing progression of increasingly severe tau pathology culminating in widespread neocortical involvement in AD4. 18F-flortaucipir and 18F-MK-6240 are shown on common scale (SUVR, 0.5–4.0). 18F-FTP images are repeated (row 3) on compressed scale (SUVR, 0.5–2.75) so that subtle differences may be more appreciated. AWOC = abnormal without complaint; GBL = global; MMSE = mini-mental state examination.
- FIGURE 2.
Comparison of 18F-flortaucipir and 18F-MK-6240 SUVR outcomes across 6 Braak stage regions, showing linear regression of values. For each Braak stage region, dynamic range of SUVR outcomes is indicated. Data point representing AD1 is shown to illustrate dilution of visually evident focal tau signal in large Braak-stage regions. CER = cerebellum.
- FIGURE 3.
Comparison of off-target binding of 18F-flortaucipir (18F-FTP) and 18F-MK-6240 in choroid plexus, striatum, and meninges. Shown are representative images of typical patterns of off-target retention in these regions (top). Distribution of SUVR outcomes is also shown (below).
- FIGURE 4.
18F-flortaucipir (18F-FTP), 18F-MK-6240, CT, and MR images of subjects with hyperostosis frontalis interna (HFI) (first row); HFI and highly calcified pineal gland (second row); marked meningeal ossification and calcification in falx cerebri (third row); and HFI and bony lesion of skull with several small meningeal calcifications (fourth row).
- FIGURE 5.
Voxel-based comparison of 18F-flortaucipir and 18F-MK-6240 retention. Shown are T-maps of significant contrasts (P < 0.05, uncorrected [T > 1.76]), where 18F-FTP > 18F-MK-6240 (A) and 18F-MK-6240 > 18F-FTP (B). T-maps are shown overlaid on average MR image generated from 15 subjects.
- FIGURE 6.
Grouping of FreeSurfer regions to correspond to Braak pathologic stages (I–VI).
Tables
Subject no. Age (y) Sex MMSE Education (y) Scan interval (d) Diagnosis AD1 83 M 20 16 2 Probable AD (atypical) AD2 68 M 23 14 6 Probable AD AD3 86 M 15 12 1 Probable AD AD4 53 M 9 12 2 Probable AD AD5 64 F 29 12 1 Probable AD MCI1 77 M 22 12 20 MCI-amnestic + other NC1 79 F 24 12 7 Abnormal w/o complaint NC2 79 F 30 18 52 Normal cognition NC3 79 F 28 14 54 Abnormal w/o complaint NC4 76 F 30 14 48 Abnormal w/o complaint NC5 76 M 22 11 26 Abnormal w/o complaint NC6 73 F 30 18 24 Abnormal w/o complaint NC7 82 F 30 14 30 Abnormal w/o complaint NC8 75 F 30 14 19 Normal cognition NC9 69 F 30 16 49 Normal cognition MMSE = mini-mental state examination; w/o = without.
MTL NEO PiB GBL Subject no. FTP MK FTP MK SUVR Centiloids Aβ status AD1 POS POS POS POS 2.53 132 POS AD2 POS POS POS POS 2.42 112 POS AD3 POS POS POS POS 2.3 103 POS AD4 POS POS POS POS 2.47 129 POS AD5 POS POS POS POS 2.51 121 POS MCI1 POS POS NEG NEG 1.24 0 NEG NC1 POS POS POS POS 1.56 50 POS NC2 NEG NEG NEG NEG 1.13 −2 NEG NC3 NEG NEG NEG NEG 1.13 −10 NEG NC4 POS POS POS POS 1.31 19 NEG NC5 NEG NEG NEG NEG 1.14 4 NEG NC6 NEG NEG NEG NEG 1.18 9 NEG NC7 NEG NEG NEG NEG 1.16 −5 NEG NC8 NEG NEG NEG NEG 1.21 4 NEG NC9 NEG NEG NEG NEG 1.29 6 NEG FTP = 18F-flortaucipir; MK = 18F-MK-6240; POS = positive; NEG = negative.
Region Tracer κ z score P MTL FTP 0.836 (0.675–0.997) 10.2 <<0.0001 MK 0.813 (0.653–0.973) 9.96 <<0.0001 NEO FTP 0.733 (0.573–0.893) 8.98 <<0.0001 MK 0.760 (0.600–0.920) 9.3 <<0.0001 All FTP 0.785 (0.672–0.898) 13.6 <<0.0001 MK 0.787 (0.674–0.900) 13.6 <<0.0001 κ = Fleiss κ-statistic.
Data in parentheses are 95% CIs.
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