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Journal of Nuclear Medicine

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Research ArticleClinical (Oncology: GU)

A Novel Time–Activity Information-Sharing Approach Using Nonlinear Mixed Models for Patient-Specific Dosimetry with Reduced Imaging Time Points: Application in SPECT/CT After 177Lu-DOTATATE

Theresa P. Devasia, Yuni K. Dewaraja, Kirk A. Frey, Ka Kit Wong and Matthew J. Schipper
Journal of Nuclear Medicine August 2021, 62 (8) 1118-1125; DOI: https://doi.org/10.2967/jnumed.120.256255
Theresa P. Devasia
1Department of Biostatistics, University of Michigan, Ann Arbor, Michigan;
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Yuni K. Dewaraja
2Department of Radiology, University of Michigan, Ann Arbor, Michigan; and
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Kirk A. Frey
2Department of Radiology, University of Michigan, Ann Arbor, Michigan; and
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Ka Kit Wong
2Department of Radiology, University of Michigan, Ann Arbor, Michigan; and
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Matthew J. Schipper
1Department of Biostatistics, University of Michigan, Ann Arbor, Michigan;
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Journal of Nuclear Medicine: 62 (8)
Journal of Nuclear Medicine
Vol. 62, Issue 8
August 1, 2021
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A Novel Time–Activity Information-Sharing Approach Using Nonlinear Mixed Models for Patient-Specific Dosimetry with Reduced Imaging Time Points: Application in SPECT/CT After 177Lu-DOTATATE
Theresa P. Devasia, Yuni K. Dewaraja, Kirk A. Frey, Ka Kit Wong, Matthew J. Schipper
Journal of Nuclear Medicine Aug 2021, 62 (8) 1118-1125; DOI: 10.2967/jnumed.120.256255

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A Novel Time–Activity Information-Sharing Approach Using Nonlinear Mixed Models for Patient-Specific Dosimetry with Reduced Imaging Time Points: Application in SPECT/CT After 177Lu-DOTATATE
Theresa P. Devasia, Yuni K. Dewaraja, Kirk A. Frey, Ka Kit Wong, Matthew J. Schipper
Journal of Nuclear Medicine Aug 2021, 62 (8) 1118-1125; DOI: 10.2967/jnumed.120.256255
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Keywords

  • mixed model
  • 177Lu-DOTATATE
  • radionuclide therapy
  • dosimetry
  • SPECT/CT
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