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Research ArticleClinical Investigation

A Phase 1 and Biodistribution Study of ABT-806i, an 111In-Radiolabeled Conjugate of the Tumor-Specific Anti-EGFR Antibody ABT-806

Hui K. Gan, Matthew Burge, Benjamin Solomon, Sze Ting Lee, Kyle D. Holen, Yumin Zhang, Marika Ciprotti, F.T. Lee, Wijith Munasinghe, JuDee Fischer, Peter Ansell, Gerard Fox, Hao Xiong, Edward B. Reilly, Rod Humerickhouse and Andrew M. Scott
Journal of Nuclear Medicine June 2021, 62 (6) 787-794; DOI: https://doi.org/10.2967/jnumed.120.253146
Hui K. Gan
1Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia
2School of Cancer Medicine, La Trobe University, Melbourne, Australia
3Department of Medicine, University of Melbourne, Melbourne, Australia
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Matthew Burge
4Royal Brisbane and Women's Hospital, Brisbane, Australia
5University of Queensland, Brisbane, Australia
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Benjamin Solomon
3Department of Medicine, University of Melbourne, Melbourne, Australia
6Peter MacCallum Cancer Centre, Melbourne, Australia
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Sze Ting Lee
1Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia
2School of Cancer Medicine, La Trobe University, Melbourne, Australia
7Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia
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Kyle D. Holen
8AbbVie, North Chicago, Illinois; and
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Yumin Zhang
9Sinotau Pharmaceutical Group, Beijing, China
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Marika Ciprotti
1Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia
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F.T. Lee
1Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia
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Wijith Munasinghe
8AbbVie, North Chicago, Illinois; and
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JuDee Fischer
8AbbVie, North Chicago, Illinois; and
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Peter Ansell
8AbbVie, North Chicago, Illinois; and
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Gerard Fox
8AbbVie, North Chicago, Illinois; and
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Hao Xiong
8AbbVie, North Chicago, Illinois; and
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Edward B. Reilly
8AbbVie, North Chicago, Illinois; and
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Rod Humerickhouse
8AbbVie, North Chicago, Illinois; and
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Andrew M. Scott
1Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia
2School of Cancer Medicine, La Trobe University, Melbourne, Australia
3Department of Medicine, University of Melbourne, Melbourne, Australia
7Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia
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Article Information

vol. 62 no. 6 787-794
DOI 
https://doi.org/10.2967/jnumed.120.253146
PubMed 
33509972

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication July 8, 2020
  • Accepted for publication September 16, 2020
  • Published online June 1, 2021.

Article Versions

  • previous version (January 28, 2021 - 06:23).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2021 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Hui K. Gan1–3,
  2. Matthew Burge4,5,
  3. Benjamin Solomon3,6,
  4. Sze Ting Lee1,2,7,
  5. Kyle D. Holen8,
  6. Yumin Zhang9,
  7. Marika Ciprotti1,
  8. F.T. Lee1,
  9. Wijith Munasinghe8,
  10. JuDee Fischer8,
  11. Peter Ansell8,
  12. Gerard Fox8,
  13. Hao Xiong8,
  14. Edward B. Reilly8,
  15. Rod Humerickhouse8 and
  16. Andrew M. Scott1–37
  1. 1Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia
  2. 2School of Cancer Medicine, La Trobe University, Melbourne, Australia
  3. 3Department of Medicine, University of Melbourne, Melbourne, Australia
  4. 4Royal Brisbane and Women's Hospital, Brisbane, Australia
  5. 5University of Queensland, Brisbane, Australia
  6. 6Peter MacCallum Cancer Centre, Melbourne, Australia
  7. 7Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia
  8. 8AbbVie, North Chicago, Illinois; and
  9. 9Sinotau Pharmaceutical Group, Beijing, China
  1. For correspondence or reprints contact: Hui K. Gan, Cancer Clinical Trial Center Austin Hospital, 145 Studley Rd., Heidelberg Victoria 3084, Australia. E-mail: hui.gan{at}onjcri.org.au
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Journal of Nuclear Medicine: 62 (6)
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A Phase 1 and Biodistribution Study of ABT-806i, an 111In-Radiolabeled Conjugate of the Tumor-Specific Anti-EGFR Antibody ABT-806
Hui K. Gan, Matthew Burge, Benjamin Solomon, Sze Ting Lee, Kyle D. Holen, Yumin Zhang, Marika Ciprotti, F.T. Lee, Wijith Munasinghe, JuDee Fischer, Peter Ansell, Gerard Fox, Hao Xiong, Edward B. Reilly, Rod Humerickhouse, Andrew M. Scott
Journal of Nuclear Medicine Jun 2021, 62 (6) 787-794; DOI: 10.2967/jnumed.120.253146

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A Phase 1 and Biodistribution Study of ABT-806i, an 111In-Radiolabeled Conjugate of the Tumor-Specific Anti-EGFR Antibody ABT-806
Hui K. Gan, Matthew Burge, Benjamin Solomon, Sze Ting Lee, Kyle D. Holen, Yumin Zhang, Marika Ciprotti, F.T. Lee, Wijith Munasinghe, JuDee Fischer, Peter Ansell, Gerard Fox, Hao Xiong, Edward B. Reilly, Rod Humerickhouse, Andrew M. Scott
Journal of Nuclear Medicine Jun 2021, 62 (6) 787-794; DOI: 10.2967/jnumed.120.253146
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