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Research ArticleThe State of the Art

The Role of 89Zr-Immuno-PET in Navigating and Derisking the Development of Biopharmaceuticals

Guus A.M.S. van Dongen, Wissam Beaino, Albert D. Windhorst, Gerben J.C. Zwezerijnen, Daniela E. Oprea-Lager, N. Harry Hendrikse, Cornelis van Kuijk, Ronald Boellaard, Marc C. Huisman and Danielle J. Vugts
Journal of Nuclear Medicine April 2021, 62 (4) 438-445; DOI: https://doi.org/10.2967/jnumed.119.239558
Guus A.M.S. van Dongen
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Wissam Beaino
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Albert D. Windhorst
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Gerben J.C. Zwezerijnen
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Daniela E. Oprea-Lager
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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N. Harry Hendrikse
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Cornelis van Kuijk
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Ronald Boellaard
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Marc C. Huisman
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Danielle J. Vugts
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Journal of Nuclear Medicine: 62 (4)
Journal of Nuclear Medicine
Vol. 62, Issue 4
April 1, 2021
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The Role of 89Zr-Immuno-PET in Navigating and Derisking the Development of Biopharmaceuticals
Guus A.M.S. van Dongen, Wissam Beaino, Albert D. Windhorst, Gerben J.C. Zwezerijnen, Daniela E. Oprea-Lager, N. Harry Hendrikse, Cornelis van Kuijk, Ronald Boellaard, Marc C. Huisman, Danielle J. Vugts
Journal of Nuclear Medicine Apr 2021, 62 (4) 438-445; DOI: 10.2967/jnumed.119.239558

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The Role of 89Zr-Immuno-PET in Navigating and Derisking the Development of Biopharmaceuticals
Guus A.M.S. van Dongen, Wissam Beaino, Albert D. Windhorst, Gerben J.C. Zwezerijnen, Daniela E. Oprea-Lager, N. Harry Hendrikse, Cornelis van Kuijk, Ronald Boellaard, Marc C. Huisman, Danielle J. Vugts
Journal of Nuclear Medicine Apr 2021, 62 (4) 438-445; DOI: 10.2967/jnumed.119.239558
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  • Article
    • Abstract
    • THE EMERGING ROLE OF BIOLOGICALS
    • POTENTIAL ROLE OF 89ZR-IMMUNO-PET
    • TECHNICAL STATE OF THE ART OF 89ZR-IMMUNO-PET
    • 89ZR-IMMUNO-PET IN DRUG DEVELOPMENT
    • CONCLUSION
    • DISCLOSURE
    • Footnotes
    • REFERENCES
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  • Long Versus Short Axial Field of View Immuno-PET/CT: Semiquantitative Evaluation for 89Zr-Trastuzumab
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  • Improving Tumor Penetration of Antibodies and Antibody-Drug Conjugates: Taking Away the Barriers for Trojan Horses
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More in this TOC Section

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  • Theranostics for Neuroblastoma: Making Molecular Radiotherapy Work Better
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Keywords

  • 89Zr-immuno-PET
  • Monoclonal Antibodies
  • biopharmaceuticals
  • antibody–drug conjugates
  • immune checkpoint inhibitors
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