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Research ArticleThe State of the Art

The Role of 89Zr-Immuno-PET in Navigating and Derisking the Development of Biopharmaceuticals

Guus A.M.S. van Dongen, Wissam Beaino, Albert D. Windhorst, Gerben J.C. Zwezerijnen, Daniela E. Oprea-Lager, N. Harry Hendrikse, Cornelis van Kuijk, Ronald Boellaard, Marc C. Huisman and Danielle J. Vugts
Journal of Nuclear Medicine April 2021, 62 (4) 438-445; DOI: https://doi.org/10.2967/jnumed.119.239558
Guus A.M.S. van Dongen
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Wissam Beaino
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Albert D. Windhorst
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Gerben J.C. Zwezerijnen
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Daniela E. Oprea-Lager
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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N. Harry Hendrikse
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Cornelis van Kuijk
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Ronald Boellaard
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Marc C. Huisman
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Danielle J. Vugts
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Article Information

vol. 62 no. 4 438-445
DOI 
https://doi.org/10.2967/jnumed.119.239558
PubMed 
33277395

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication September 17, 2020
  • Accepted for publication December 1, 2020
  • Published online March 29, 2021.

Article Versions

  • previous version (December 4, 2020 - 12:52).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2021 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Guus A.M.S. van Dongen,
  2. Wissam Beaino,
  3. Albert D. Windhorst,
  4. Gerben J.C. Zwezerijnen,
  5. Daniela E. Oprea-Lager,
  6. N. Harry Hendrikse,
  7. Cornelis van Kuijk,
  8. Ronald Boellaard,
  9. Marc C. Huisman and
  10. Danielle J. Vugts
  1. Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
  1. For correspondence or reprints contact: Guus A.M.S. van Dongen, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. E-mail: gams.vandongen{at}amsterdamumc.nl
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Jan 2021472025
Feb 2021241029
Mar 20218743868
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Journal of Nuclear Medicine: 62 (4)
Journal of Nuclear Medicine
Vol. 62, Issue 4
April 1, 2021
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The Role of 89Zr-Immuno-PET in Navigating and Derisking the Development of Biopharmaceuticals
Guus A.M.S. van Dongen, Wissam Beaino, Albert D. Windhorst, Gerben J.C. Zwezerijnen, Daniela E. Oprea-Lager, N. Harry Hendrikse, Cornelis van Kuijk, Ronald Boellaard, Marc C. Huisman, Danielle J. Vugts
Journal of Nuclear Medicine Apr 2021, 62 (4) 438-445; DOI: 10.2967/jnumed.119.239558

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The Role of 89Zr-Immuno-PET in Navigating and Derisking the Development of Biopharmaceuticals
Guus A.M.S. van Dongen, Wissam Beaino, Albert D. Windhorst, Gerben J.C. Zwezerijnen, Daniela E. Oprea-Lager, N. Harry Hendrikse, Cornelis van Kuijk, Ronald Boellaard, Marc C. Huisman, Danielle J. Vugts
Journal of Nuclear Medicine Apr 2021, 62 (4) 438-445; DOI: 10.2967/jnumed.119.239558
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  • Article
    • Abstract
    • THE EMERGING ROLE OF BIOLOGICALS
    • POTENTIAL ROLE OF 89ZR-IMMUNO-PET
    • TECHNICAL STATE OF THE ART OF 89ZR-IMMUNO-PET
    • 89ZR-IMMUNO-PET IN DRUG DEVELOPMENT
    • CONCLUSION
    • DISCLOSURE
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Keywords

  • 89Zr-immuno-PET
  • monoclonal antibodies
  • biopharmaceuticals
  • antibody–drug conjugates
  • immune checkpoint inhibitors
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