Article Figures & Data
Figures
- FIGURE 1.
(A) Schematic illustration of MC1R-avid radiolabeled α-MSH peptide to detect B16/F1 flank melanoma (T) and B16/F10 pulmonary metastatic melanoma (Mets) in mice and melanoma metastases in a melanoma patient. BM, LM, CM, and IM represent melanoma metastases in brain, lung, connective tissue, and intestines, respectively. (B) Representative α-MSH peptides. (Human and animal images reprinted with permission of 5, 19, and 20.)
- FIGURE 2.
Molecular model of α-MSH-PEG-Cy5-C′ dot. Silicon, oxygen, carbon, nitrogen, and sulfur atoms are colored purple, red, gray, blue, and yellow, respectively. DOTA chelator was attached to epsilon amine of d-Lys residue for 177Lu and 225Ac radiolabeling. (Reprinted with permission of 29.)
- FIGURE 3.
(A) Schematic structure of DOTA-PEG4-LLP2A. (B) Biodistribution of 177Lu/68Ga-DOTA-PEG4-LLP2A and survival curves for treatments with 177Lu-DOTA-PEG4-LLP2A alone and combined with immune checkpoint inhibitors. (Reprinted with permission of 38 and 39.)
