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Journal of Nuclear Medicine

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Research ArticleFocus on Molecular Imaging

Advances in Receptor-Targeted Radiolabeled Peptides for Melanoma Imaging and Therapy

Yubin Miao and Thomas P. Quinn
Journal of Nuclear Medicine March 2021, 62 (3) 313-318; DOI: https://doi.org/10.2967/jnumed.120.243840
Yubin Miao
1Department of Radiology, School of Medicine, University of Colorado Denver, Aurora, Colorado; and
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Thomas P. Quinn
2Department of Biochemistry, University of Missouri–Columbia, and Harry S. Truman Veterans’ Hospital, Columbia, Missouri
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Abstract

Melanocortin-1 receptor (MC1R) and very late antigen-4 (VLA-4, integrin α4β1) are 2 attractive molecular targets for developing peptide radiopharmaceuticals for melanoma imaging and therapy. MC1R- and VLA-4–targeting peptides and peptide-conjugated Cornell prime dots (C′ dots) can serve as delivery vehicles to target both diagnostic and therapeutic radionuclides to melanoma cells for imaging and therapy. This review highlights the advances of MC1R- and VLA-4–targeted radiolabeled peptides and peptide-conjugated C′ dots for melanoma imaging and therapy. The promising preclinical and clinical results of these new peptide radiopharmaceuticals present an optimistic outlook for clinical translation into receptor-targeting melanoma imaging and radionuclide therapy in the future.

  • melanocortin-1 receptor
  • very late antigen-4
  • peptide radiopharmaceuticals
  • Cornell prime dots
  • melanoma imaging and therapy

Footnotes

  • Published online Dec. 4, 2020.

  • © 2021 by the Society of Nuclear Medicine and Molecular Imaging.
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Journal of Nuclear Medicine: 62 (3)
Journal of Nuclear Medicine
Vol. 62, Issue 3
March 1, 2021
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Advances in Receptor-Targeted Radiolabeled Peptides for Melanoma Imaging and Therapy
Yubin Miao, Thomas P. Quinn
Journal of Nuclear Medicine Mar 2021, 62 (3) 313-318; DOI: 10.2967/jnumed.120.243840

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Advances in Receptor-Targeted Radiolabeled Peptides for Melanoma Imaging and Therapy
Yubin Miao, Thomas P. Quinn
Journal of Nuclear Medicine Mar 2021, 62 (3) 313-318; DOI: 10.2967/jnumed.120.243840
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  • Article
    • Abstract
    • MC1R-TARGETED DIAGNOSTIC AND THERAPEUTIC α-MELANOCYTE–STIMULATING HORMONE (α-MSH) PEPTIDES
    • MC1R-TARGETED α-MSH-FUNCTIONALIZED DIAGNOSTIC AND THERAPEUTIC C′ DOTS
    • VLA-4–TARGETED DIAGNOSTIC AND THERAPEUTIC LLP2A PEPTIDES
    • CONCLUSION
    • DISCLOSURE
    • Acknowledgments
    • Footnotes
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Keywords

  • melanocortin-1 receptor
  • very late antigen-4
  • peptide radiopharmaceuticals
  • Cornell prime dots
  • melanoma imaging and therapy
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