Improved 223Ra Therapy with Combination Epithelial Sodium Channel Blockade

Diane S. Abou; Amanda Fears; Lucy Summer; Mark Longtine; Nadia Benabdallah; Ryan C. Riddle; David Ulmert; Jeff M. Michalski; Richard L. Wahl; Denise Chesner; Michele Doucet; Nicholas C. Zachos; Brian W. Simons; Daniel L.J. Thorek

doi:10.2967/jnumed.121.261977

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Improved ²²³Ra Therapy with Combination Epithelial Sodium Channel Blockade

Diane S. Abou, Amanda Fears, Lucy Summer, Mark Longtine, Nadia Benabdallah, Ryan C. Riddle, David Ulmert, Jeff M. Michalski, Richard L. Wahl, Denise Chesner, Michele Doucet, Nicholas C. Zachos, Brian W. Simons and Daniel L.J. Thorek

Journal of Nuclear Medicine December 2021, 62 (12) 1751-1758; DOI: https://doi.org/10.2967/jnumed.121.261977

Diane S. Abou

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Amanda Fears

1Mallinckrodt Institute of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri;

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Lucy Summer

1Mallinckrodt Institute of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri;

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Mark Longtine

1Mallinckrodt Institute of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri;

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Nadia Benabdallah

1Mallinckrodt Institute of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri;

2Program in Quantitative Molecular Therapeutics, School of Medicine, Washington University in St. Louis, St. Louis, Missouri;

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Ryan C. Riddle

4Department of Orthopaedics, Johns Hopkins University, Baltimore, Maryland;

5Research and Development Service, Baltimore VA Medical Center, Baltimore, Maryland;

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David Ulmert

6Department of Pharmacology, UCLA, Los Angeles, California;

7Department of Clinical Sciences, Lund University, Lund, Sweden;

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Jeff M. Michalski

8Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri;

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Richard L. Wahl

1Mallinckrodt Institute of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri;

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Denise Chesner

9Division of Gastroenterology and Hepatology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland;

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Michele Doucet

10Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland;

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Nicholas C. Zachos

9Division of Gastroenterology and Hepatology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland;

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Brian W. Simons

11Center for Comparative Medicine, Baylor College of Medicine, Houston, Texas; and

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Daniel L.J. Thorek

12Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri

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Journal of Nuclear Medicine

Vol. 62, Issue 12

December 1, 2021

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Improved ²²³Ra Therapy with Combination Epithelial Sodium Channel Blockade

Journal of Nuclear Medicine Dec 2021, 62 (12) 1751-1758; DOI: 10.2967/jnumed.121.261977

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Improved ²²³Ra Therapy with Combination Epithelial Sodium Channel Blockade

Journal of Nuclear Medicine Dec 2021, 62 (12) 1751-1758; DOI: 10.2967/jnumed.121.261977

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Keywords

223Ra
amiloride
ion channel
gastrointestinal
Bone

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