First-in-Humans Application of 161Tb: A Feasibility Study Using 161Tb-DOTATOC

Richard P. Baum; Aviral Singh; Harshad R. Kulkarni; Peter Bernhardt; Tobias Rydén; Christiane Schuchardt; Nadezda Gracheva; Pascal V. Grundler; Ulli Köster; Dirk Müller; Michael Pröhl; Jan Rijn Zeevaart; Roger Schibli; Nicholas P. van der Meulen; Cristina Müller

doi:10.2967/jnumed.120.258376

Research ArticleBrief Communication

First-in-Humans Application of ¹⁶¹Tb: A Feasibility Study Using ¹⁶¹Tb-DOTATOC

Richard P. Baum, Aviral Singh, Harshad R. Kulkarni, Peter Bernhardt, Tobias Rydén, Christiane Schuchardt, Nadezda Gracheva, Pascal V. Grundler, Ulli Köster, Dirk Müller, Michael Pröhl, Jan Rijn Zeevaart, Roger Schibli, Nicholas P. van der Meulen and Cristina Müller

Journal of Nuclear Medicine October 2021, 62 (10) 1391-1397; DOI: https://doi.org/10.2967/jnumed.120.258376

Richard P. Baum

1Theranostics Center for Molecular Radiotherapy and Precision Oncology, ENETS Center of Excellence, Zentralklinik Bad Berka, Bad Berka, Germany;

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Aviral Singh

1Theranostics Center for Molecular Radiotherapy and Precision Oncology, ENETS Center of Excellence, Zentralklinik Bad Berka, Bad Berka, Germany;

2GROW–School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands;

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Harshad R. Kulkarni

1Theranostics Center for Molecular Radiotherapy and Precision Oncology, ENETS Center of Excellence, Zentralklinik Bad Berka, Bad Berka, Germany;

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Peter Bernhardt

3Department of Radiation Physics, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;

4Department of Medical Physics and Medical Bioengineering, Sahlgrenska University Hospital, Gothenburg, Gothenburg, Sweden;

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Tobias Rydén

3Department of Radiation Physics, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;

4Department of Medical Physics and Medical Bioengineering, Sahlgrenska University Hospital, Gothenburg, Gothenburg, Sweden;

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Christiane Schuchardt

1Theranostics Center for Molecular Radiotherapy and Precision Oncology, ENETS Center of Excellence, Zentralklinik Bad Berka, Bad Berka, Germany;

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Nadezda Gracheva

5Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland;

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Pascal V. Grundler

5Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland;

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Ulli Köster

6Institut Laue Langevin, Grenoble, France;

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Dirk Müller

7Department of Radiopharmacy, Zentralklinik Bad Berka, Bad Berka, Germany;

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Michael Pröhl

7Department of Radiopharmacy, Zentralklinik Bad Berka, Bad Berka, Germany;

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Jan Rijn Zeevaart

8Radiochemistry, South African Nuclear Energy Corporation (Necsa), Pelindaba, South Africa;

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Roger Schibli

5Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland;

9Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland; and

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Nicholas P. van der Meulen

5Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland;

10Laboratory of Radiochemistry, Paul Scherrer Institute, Villigen-PSI, Switzerland

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Cristina Müller

5Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland;

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First-in-Humans Application of ¹⁶¹Tb: A Feasibility Study Using ¹⁶¹Tb-DOTATOC

Journal of Nuclear Medicine Oct 2021, 62 (10) 1391-1397; DOI: 10.2967/jnumed.120.258376

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First-in-Humans Application of ¹⁶¹Tb: A Feasibility Study Using ¹⁶¹Tb-DOTATOC

Journal of Nuclear Medicine Oct 2021, 62 (10) 1391-1397; DOI: 10.2967/jnumed.120.258376

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Keywords

161Tb
SPECT/CT imaging
DOTATOC
Auger electrons
first-in-humans

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