Table of Contents

Theranostics

• Clinical

  • BRIEF COMMUNICATION

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      First-in-Humans Application of ¹⁶¹Tb: A Feasibility Study Using ¹⁶¹Tb-DOTATOC

      Richard P. Baum, Aviral Singh, Harshad R. Kulkarni, Peter Bernhardt, Tobias Rydén, Christiane Schuchardt, Nadezda Gracheva, Pascal V. Grundler, Ulli Köster, Dirk Müller, Michael Pröhl, Jan Rijn Zeevaart, Roger Schibli, Nicholas P. van der Meulen and Cristina Müller

      Journal of Nuclear Medicine October 1, 2021, 62 (10) 1391-1397; DOI: https://doi.org/10.2967/jnumed.120.258376

  • FEATURED ARTICLE OF THE MONTH

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      A Prospective, Randomized, Double-Blind Study to Evaluate the Safety, Biodistribution, and Dosimetry of ⁶⁸Ga-NODAGA-LM3 and ⁶⁸Ga-DOTA-LM3 in Patients with Well-Differentiated Neuroendocrine Tumors

      Wenjia Zhu, Yuejuan Cheng, Ru Jia, Hong Zhao, Chunmei Bai, Jianming Xu, Shaobo Yao and Li Huo

      Journal of Nuclear Medicine October 1, 2021, 62 (10) 1398-1405; DOI: https://doi.org/10.2967/jnumed.120.253096
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    Quantitative ⁶⁸Ga-DOTATATE PET/CT Parameters for the Prediction of Therapy Response in Patients with Progressive Metastatic Neuroendocrine Tumors Treated with ¹⁷⁷Lu-DOTATATE

    Claudia Ortega, Rebecca K.S. Wong, Josh Schaefferkoetter, Patrick Veit-Haibach, Sten Myrehaug, Rosalyn Juergens, David Laidley, Reut Anconina, Amy Liu and Ur Metser

    Journal of Nuclear Medicine October 1, 2021, 62 (10) 1406-1414; DOI: https://doi.org/10.2967/jnumed.120.256727
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    Improved Primary Staging of Marginal-Zone Lymphoma by Addition of CXCR4-Directed PET/CT

    Johannes Duell, Franziska Krummenast, Andreas Schirbel, Philipp Klassen, Samuel Samnick, Hilka Rauert-Wunderlich, Leo Rasche, Andreas K. Buck, Hans-Jürgen Wester, Andreas Rosenwald, Herrmann Einsele, Max S. Topp, Constantin Lapa and Malte Kircher

    Journal of Nuclear Medicine October 1, 2021, 62 (10) 1415-1421; DOI: https://doi.org/10.2967/jnumed.120.257279
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    Matched-Pair Comparison of ¹⁸F-DCFPyL PET/CT and ¹⁸F-PSMA-1007 PET/CT in 240 Prostate Cancer Patients: Interreader Agreement and Lesion Detection Rate of Suspected Lesions

    Maurits Wondergem, Friso M. van der Zant, Wouter A.M. Broos and Remco J.J. Knol

    Journal of Nuclear Medicine October 1, 2021, 62 (10) 1422-1429; DOI: https://doi.org/10.2967/jnumed.120.258574
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    Prospective, Single-Arm Trial Evaluating Changes in Uptake Patterns on Prostate-Specific Membrane Antigen–Targeted ¹⁸F-DCFPyL PET/CT in Patients with Castration-Resistant Prostate Cancer Starting Abiraterone or Enzalutamide

    Katherine A. Zukotynski, Urban Emmenegger, Sebastien Hotte, Anil Kapoor, Wei Fu, Amanda L. Blackford, John Valliant, François Bénard, Chun K. Kim, Mark C. Markowski, Mario A. Eisenberger, Emmanuel S. Antonarakis, Kenneth J. Pienta, Michael A. Gorin, Matthew Lubanovic, Jihyun Kim, Martin G. Pomper, Steve Y. Cho and Steven P. Rowe

    Journal of Nuclear Medicine October 1, 2021, 62 (10) 1430-1437; DOI: https://doi.org/10.2967/jnumed.120.259069

  • INVITED PERSPECTIVE

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      RESIST-PC: U.S. Academic Foray into PSMA Theranostic Trials

      Amir Iravani and Thomas A. Hope

      Journal of Nuclear Medicine October 1, 2021, 62 (10) 1438-1439; DOI: https://doi.org/10.2967/jnumed.121.262602
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    Prospective phase 2 trial of PSMA-targeted molecular RadiothErapy with ¹⁷⁷Lu-PSMA-617 for metastatic castration-reSISTant Prostate Cancer (RESIST-PC): efficacy results of the UCLA cohort

    Jeremie Calais, Andrei Gafita, Matthias Eiber, Wesley R. Armstrong, Jeannine Gartmann, Pan Thin, Kathleen Nguyen, Vincent Lok, Laura Gosa, Tristan Grogan, Rouzbeh Esfandiari, Martin Allen-Auerbach, Andrew Quon, Shadfar Bahri, Pawan Gupta, Linda Gardner, David Ranganathan, Roger Slavik, Magnus Dahlbom, Ken Herrmann, Ebrahim Delpassand, Wolfgang P. Fendler and Johannes Czernin

    Journal of Nuclear Medicine October 1, 2021, 62 (10) 1440-1446; DOI: https://doi.org/10.2967/jnumed.121.261982
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    Safety of PSMA-Targeted Molecular Radioligand Therapy with ¹⁷⁷Lu-PSMA-617: Results from the Prospective Multicenter Phase 2 Trial RESIST-PC (NCT03042312)

    Jeremie Calais, Johannes Czernin, Pan Thin, Jeannine Gartmann, Kathleen Nguyen, Wesley R. Armstrong, Martin Allen-Auerbach, Andrew Quon, Shadfar Bahri, Pawan Gupta, Linda Gardner, Magnus Dahlbom, Beilei He, Rouzbeh Esfandiari, David Ranganathan, Ken Herrmann, Matthias Eiber, Wolfgang P. Fendler and Ebrahim Delpassand

    Journal of Nuclear Medicine October 1, 2021, 62 (10) 1447-1456; DOI: https://doi.org/10.2967/jnumed.121.262543

  • BRIEF COMMUNICATION

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      Head-to-Head Comparison of ⁶⁸Ga-NOTA (⁶⁸Ga-NGUL) and ⁶⁸Ga-PSMA-11 in Patients with Metastatic Prostate Cancer: A Prospective Study

      Minseok Suh, Hyung-Jun Im, Hyun Gee Ryoo, Keon Wook Kang, Jae Min Jeong, Sneha Prakash, Sanjana Ballal, Madhav P. Yadav, Chandrasekhar Bal, Chang Wook Jeong, Cheol Kwak and Gi Jeong Cheon

      Journal of Nuclear Medicine October 1, 2021, 62 (10) 1457-1460; DOI: https://doi.org/10.2967/jnumed.120.258434

• Basic

  • FEATURED BASIC SCIENCE ARTICLE

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      Rational Linker Design to Accelerate Excretion and Reduce Background Uptake of Peptidomimetic PSMA-Targeting Hybrid Molecules

      Ann-Christin Eder, Martin Schäfer, Jana Schmidt, Ulrike Bauder-Wüst, Mareike Roscher, Karin Leotta, Uwe Haberkorn, Klaus Kopka and Matthias Eder

      Journal of Nuclear Medicine October 1, 2021, 62 (10) 1461-1467; DOI: https://doi.org/10.2967/jnumed.120.248443
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    Utility of ²¹¹At-Trastuzumab for the Treatment of Metastatic Gastric Cancer in the Liver: Evaluation of a Preclinical α-Radioimmunotherapy Approach in a Clinically Relevant Mouse Model

    Huizi Keiko Li, Yukie Morokoshi, Satoshi Kodaira, Tamon Kusumoto, Katsuyuki Minegishi, Hiroaki Kanda, Kotaro Nagatsu and Sumitaka Hasegawa

    Journal of Nuclear Medicine October 1, 2021, 62 (10) 1468-1474; DOI: https://doi.org/10.2967/jnumed.120.249300
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    Identification of a PET Radiotracer for Imaging of the Folate Receptor-α: A Potential Tool to Select Patients for Targeted Tumor Therapy

    Patrycja Guzik, Hsin-Yu Fang, Luisa M. Deberle, Martina Benešová, Susan Cohrs, Silvan D. Boss, Simon M. Ametamey, Roger Schibli and Cristina Müller

    Journal of Nuclear Medicine October 1, 2021, 62 (10) 1475-1481; DOI: https://doi.org/10.2967/jnumed.120.255760