Article Figures & Data
Figures
- FIGURE 1.
Proportion of local (Tr), nodal (N1), or distant (M1) disease (A) and N/M disease extent (B) stratified by PSA range for presented patients, including previous data by Fendler et al. (6). Six patients in study of Fendler et al. were excluded because of PSA ≥ 8 wk before PET. multi = multiple or disseminated; oligo = oligometastatic; uni = unifocal. *n = 9 overlap. †n = 5 overlap.
Tables
- TABLE 1
Disease Extent Stratified by PSA at Time of Imaging According to PROMISE (n = 55) (17)
PSMA PET/CT findings Total (n = 55) Pre-PCWG3 PSA: <1.0 ng/mL (n = 21) Early PCWG3 PSA: 1.0–<2.0 ng/mL (n = 11) Early EAU PSA: 2.0–≤ 3.0 ng/mL (n = 23) Negative 14 (25) 10 (48) 0 (0) 4 (17) Tr/N1 only 16 (29) 6 (29) 3 (27) 7 (30) Local recurrence (Tr) 9 (16) 3 (14) 1 (9) 5 (22) Pelvic lymph nodes (N1) 9 (16) 3 (14) 2 (18) 4 (17) Any M1 25 (45) 5 (24) 8 (73) 12 (52) Extrapelvic lymph nodes (M1a) 15 (27) 3 (14) 3 (27) 9 (39) Bone (M1b) 13 (24) 3 (14) 4 (36) 6 (26) Soft tissue/visceral (M1c) 2 (4) 0 (0) 2 (18) 0 (0) N/M disease extent 34 (62) 8 (38) 0 (0) 16 (70) Unifocal (1) 6 (18) 2 (25) 1 (10) 3 (19) Oligometastatic (2–5) 17 (50) 4 (50) 9 (90) 4 (25) Multiple or disseminated (≥6) 11 (32) 2 (25) 0 (0) 9 (56) Data are number of patients, followed by percentage in parentheses.
- TABLE 2
Regression Analysis of Clinical Parameters and Their Respective Risk for PSMA PET/CT Detection (n = 55)
Variable n Odds ratio for PET-positive P Odds ratio for PET M1 P Age ≥ 65 40 of 55 (73) 1.3 (0.3–4.9) 0.75 0.9 (0.3–3.1) 0.91 Gleason score ≥ 8 28 of 47 (60) 1.3 (0.2–5.1) 0.70 1.2 (0.4–3.9) 0.77 PSA ≥ 1.5 ng/mL 28 of 55 (51) 3.0 (0.8–11.3) 0.11 2.0 (0.7–5.8) 0.22 PSA doubling time ≤ 6 mo 27 of 44 (61) 0.8 (0.2–3.5) 0.82 1.3 (0.4–4.2) 0.70 Locoregional disease pT3/pT4* 20 of 31 (65) 1.5 (0.2–9.4) 0.60 1.2 (0.3–5.2) 0.81 Locoregional disease pN1† 12 of 30 (40) 1.4 (0.2–9.4) 0.71 0.6 (0.1–2.5) 0.46 Primary radiation therapy 11 of 55 (20) 0.5 (0.1–2.1) 0.36 0.1 (0.0–0.7) 0.02*
Supplemental Data
Files in this Data Supplement:
