Evaluation of 11C-NR2B-SMe and Its Enantiomers as PET Radioligands for Imaging the NR2B Subunit Within the NMDA Receptor Complex in Rats

Lisheng Cai; Jeih-San Liow; Cheryl L. Morse; Sanjay Telu; Riley Davies; Michael P. Frankland; Sami S. Zoghbi; Ken Cheng; Matthew D. Hall; Robert B. Innis; Victor W. Pike

doi:10.2967/jnumed.119.235143

Research ArticleMolecular Imaging

Evaluation of ¹¹C-NR2B-SMe and Its Enantiomers as PET Radioligands for Imaging the NR2B Subunit Within the NMDA Receptor Complex in Rats

Lisheng Cai, Jeih-San Liow, Cheryl L. Morse, Sanjay Telu, Riley Davies, Michael P. Frankland, Sami S. Zoghbi, Ken Cheng, Matthew D. Hall, Robert B. Innis and Victor W. Pike

Journal of Nuclear Medicine August 2020, 61 (8) 1212-1220; DOI: https://doi.org/10.2967/jnumed.119.235143

Lisheng Cai

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and

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Jeih-San Liow

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and

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Cheryl L. Morse

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and

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Sanjay Telu

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and

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Riley Davies

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and

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Michael P. Frankland

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and

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Sami S. Zoghbi

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and

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Ken Cheng

2NCATS Chemical Genomics Center, National Institutes of Health, Rockville, Maryland

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Matthew D. Hall

2NCATS Chemical Genomics Center, National Institutes of Health, Rockville, Maryland

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Robert B. Innis

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and

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Victor W. Pike

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and

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Journal of Nuclear Medicine

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Evaluation of ¹¹C-NR2B-SMe and Its Enantiomers as PET Radioligands for Imaging the NR2B Subunit Within the NMDA Receptor Complex in Rats

Lisheng Cai, Jeih-San Liow, Cheryl L. Morse, Sanjay Telu, Riley Davies, Michael P. Frankland, Sami S. Zoghbi, Ken Cheng, Matthew D. Hall, Robert B. Innis, Victor W. Pike

Journal of Nuclear Medicine Aug 2020, 61 (8) 1212-1220; DOI: 10.2967/jnumed.119.235143

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Evaluation of ¹¹C-NR2B-SMe and Its Enantiomers as PET Radioligands for Imaging the NR2B Subunit Within the NMDA Receptor Complex in Rats

Lisheng Cai, Jeih-San Liow, Cheryl L. Morse, Sanjay Telu, Riley Davies, Michael P. Frankland, Sami S. Zoghbi, Ken Cheng, Matthew D. Hall, Robert B. Innis, Victor W. Pike

Journal of Nuclear Medicine Aug 2020, 61 (8) 1212-1220; DOI: 10.2967/jnumed.119.235143

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Keywords

NR2B subunit
NMDA receptor
GluN2B
sigma 1
NR2B-SMe

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Evaluation of ¹¹C-NR2B-SMe and Its Enantiomers as PET Radioligands for Imaging the NR2B Subunit Within the NMDA Receptor Complex in Rats

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