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Research ArticleRadiochemistry

Light-Induced Radiosynthesis of 89Zr-DFO-Azepin-Onartuzumab for Imaging the Hepatocyte Growth Factor Receptor

Simon Klingler, Rachael Fay and Jason P. Holland
Journal of Nuclear Medicine July 2020, 61 (7) 1072-1078; DOI: https://doi.org/10.2967/jnumed.119.237180
Simon Klingler
Department of Chemistry, University of Zurich, Zurich, Switzerland
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Rachael Fay
Department of Chemistry, University of Zurich, Zurich, Switzerland
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Jason P. Holland
Department of Chemistry, University of Zurich, Zurich, Switzerland
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Journal of Nuclear Medicine: 61 (7)
Journal of Nuclear Medicine
Vol. 61, Issue 7
July 1, 2020
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Light-Induced Radiosynthesis of 89Zr-DFO-Azepin-Onartuzumab for Imaging the Hepatocyte Growth Factor Receptor
Simon Klingler, Rachael Fay, Jason P. Holland
Journal of Nuclear Medicine Jul 2020, 61 (7) 1072-1078; DOI: 10.2967/jnumed.119.237180

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Light-Induced Radiosynthesis of 89Zr-DFO-Azepin-Onartuzumab for Imaging the Hepatocyte Growth Factor Receptor
Simon Klingler, Rachael Fay, Jason P. Holland
Journal of Nuclear Medicine Jul 2020, 61 (7) 1072-1078; DOI: 10.2967/jnumed.119.237180
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Radiochemistry

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Basic

  • Cyclotron-Produced 132La as a PET Imaging Surrogate for Therapeutic 225Ac
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  • Synthesis of the PET Tracer 124I-Trametinib for MAPK/ERK Kinase Distribution and Resistance Monitoring
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Keywords

  • Photoradiosynthesis
  • immuno-PET
  • antibodies
  • hepatocyte growth factor receptor (c-MET)
  • 89Zr
  • MetMAb
  • onartuzumab
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