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Research ArticleTheranostics
Open Access

Imaging DNA Damage Repair In Vivo After 177Lu-DOTATATE Therapy

Edward O’Neill, Veerle Kersemans, P. Danny Allen, Samantha Y.A. Terry, Julia Baguña Torres, Michael Mosley, Sean Smart, Boon Quan Lee, Nadia Falzone, Katherine A. Vallis, Mark W. Konijnenberg, Marion de Jong, Julie Nonnekens and Bart Cornelissen
Journal of Nuclear Medicine May 2020, 61 (5) 743-750; DOI: https://doi.org/10.2967/jnumed.119.232934
Edward O’Neill
1CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
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Veerle Kersemans
1CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
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P. Danny Allen
1CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
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Samantha Y.A. Terry
2Department of Imaging Chemistry and Biology, King’s College London, London, United Kingdom
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Julia Baguña Torres
1CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
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Michael Mosley
1CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
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Sean Smart
1CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
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Boon Quan Lee
1CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
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Nadia Falzone
1CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
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Katherine A. Vallis
1CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
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Mark W. Konijnenberg
3Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
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Marion de Jong
3Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
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Julie Nonnekens
3Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
4Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands; and
5Oncode Institute, Erasmus MC, Rotterdam, The Netherlands
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Bart Cornelissen
1CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
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Article Information

vol. 61 no. 5 743-750
DOI 
https://doi.org/10.2967/jnumed.119.232934
PubMed 
31757844

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication June 27, 2019
  • Accepted for publication October 7, 2019
  • Published online May 1, 2020.

Article Versions

  • previous version (November 22, 2019 - 10:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2020 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Edward O’Neill1,
  2. Veerle Kersemans1,
  3. P. Danny Allen1,
  4. Samantha Y.A. Terry2,
  5. Julia Baguña Torres1,
  6. Michael Mosley1,
  7. Sean Smart1,
  8. Boon Quan Lee1,
  9. Nadia Falzone1,
  10. Katherine A. Vallis1,
  11. Mark W. Konijnenberg3,
  12. Marion de Jong3,
  13. Julie Nonnekens3–5 and
  14. Bart Cornelissen1
  1. 1CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
  2. 2Department of Imaging Chemistry and Biology, King’s College London, London, United Kingdom
  3. 3Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
  4. 4Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands; and
  5. 5Oncode Institute, Erasmus MC, Rotterdam, The Netherlands
  1. For correspondence or reprints contact: Bart Cornelissen, Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Old Road Campus Research Building off Roosevelt Dr., Oxford OX3 7LJ, U.K. E-mail: bart.cornelissen{at}oncology.ox.ac.uk
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Journal of Nuclear Medicine: 61 (5)
Journal of Nuclear Medicine
Vol. 61, Issue 5
May 1, 2020
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Imaging DNA Damage Repair In Vivo After 177Lu-DOTATATE Therapy
Edward O’Neill, Veerle Kersemans, P. Danny Allen, Samantha Y.A. Terry, Julia Baguña Torres, Michael Mosley, Sean Smart, Boon Quan Lee, Nadia Falzone, Katherine A. Vallis, Mark W. Konijnenberg, Marion de Jong, Julie Nonnekens, Bart Cornelissen
Journal of Nuclear Medicine May 2020, 61 (5) 743-750; DOI: 10.2967/jnumed.119.232934

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Imaging DNA Damage Repair In Vivo After 177Lu-DOTATATE Therapy
Edward O’Neill, Veerle Kersemans, P. Danny Allen, Samantha Y.A. Terry, Julia Baguña Torres, Michael Mosley, Sean Smart, Boon Quan Lee, Nadia Falzone, Katherine A. Vallis, Mark W. Konijnenberg, Marion de Jong, Julie Nonnekens, Bart Cornelissen
Journal of Nuclear Medicine May 2020, 61 (5) 743-750; DOI: 10.2967/jnumed.119.232934
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Keywords

  • 177Lu-DOTATATE
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  • SPECT
  • DNA damage
  • neuroendocrine cancer
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