Discussions with leaders: JNM editor-in-chief Johannes Czernin, with Thomas Hope, continues a series of interviews with leaders in nuclear and molecular imaging and therapy with a conversation with John J. Sunderland, PhD, MBA, about advancing 68GA-DOTATOC through the FDA.
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The academic NDA: Sunderland outlines the story of the 68Ga-DOTATOC new drug application process, including clinical trials, structured content of the NDA document, and associated first-hand experiences from the University of Iowa.
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Introduction to radiomics: Mayerhoefer and colleagues provide an educational overview of standard radiomics workflow, the basic concepts of radiomic feature classes, and common limitations and pitfalls in radiomics studies.
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Travel after 177Lu-DOTATATE: Kendi and colleagues look at challenges to gastroenteropancreatic neuroendocrine tumor patients whose residual radiation after 177Lu-labeled DOTATATE treatment sets off alarms at U.S. borders and points of entry.
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PET tracer accuracy in gliomas: de Zwart and colleagues detail the results of a systematic review and metaanalysis comparing the diagnostic accuracies of different PET tracers in differentiating tumor progression from treatment-related changes in patients with high-grade gliomas.
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18F-FET PET in recurrent glioma: Maurer and colleagues investigate the effectiveness of 18F-FET PET imaging in differentiating glioma progression from treatment-related changes.
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89Zr-Df-IAB22M2C anti-CD8 minibody PET: Pandit-Taskar and colleagues report on first-in-human studies of the safety of this radiolabeled minibody against CD8+ T cells for imaging of these cells in patients with cancer.
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177Lu-PP-F11N for radionuclide therapy: Rottenburger and colleagues determine, using advanced 3-dimensional dosimetry in a first-in-human study, whether this minigastrin analog with therapeutic properties and a γ-ray component for imaging is a suitable agent for treatment of medullary thyroid carcinoma.
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18F- versus 68Ga-PSMA imaging: Kuten and colleagues compare the diagnostic accuracy of 18F-PSMA-1007 with that of 68Ga-PSMA-11 PET/CT in the same group of patients with newly diagnosed intermediate- or high-risk prostate cancer.
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Interpretation criteria for 68Ga-PSMA-11 PET: Toriihara and colleagues compare interreader, intrareader, and intercriteria agreement in 3 recently introduced international criteria for interpretation of 68Ga–prostate-specific membrane antigen-11 PET data in prostate cancer.
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PSMA PET/CT and biopsy for LN staging: Hinsenveld and colleagues determine the diagnostic capabilities of combined prostate-specific membrane antigen PET/CT and sentinel node biopsy in PSMA PET/CT–negative patients for primary lymph node staging in prostate cancer.
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18F-DCFPyL PET/CT in prostate cancer: Song and colleagues present their institutional experience assessing the positivity rate of PET/CT with this prostate-specific membrane antigen–targeting agent in patients with biochemical recurrence of prostate cancer.
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Imaging AUC in BCR prostate cancer: Jadvar and members of a multiorganizational workgroup provide a consensus document on the appropriate use of imaging in diagnostic evaluation of patients with biochemical recurrence of prostate cancer after definitive primary treatment.
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Theranostics targeting FAP: Watabe and colleagues use 64Cu and 225Ac, with long half-lives, to label fibroblast activation protein inhibitors in mice with human pancreatic cancer xenografts to assess the potential of α-therapy targeting FAP in cancer stroma.
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Imaging β-cell mass with 11C-(+)-PHNO: Bini and colleagues describe pancreatic PET imaging parameters with this dopamine D2 and D3 receptor agonist to differentiate healthy controls from individuals with type 1 diabetes mellitus.
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18F-Fluorocholine in PHPT: Cuderman and colleagues compare the efficiency of established conventional scintigraphic imaging modalities with 18F-fluorocholine PET/CT imaging in preoperative localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism.
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11C-Choline PET in hyperparathyroidism: Liu and colleagues assess the value of 11C-choline PET in patients with primary hyperparathyroidism and negative or discordant results on 99mTc-sestamibi imaging and neck ultrasound.
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18F-FDG inflammation imaging after aortic constriction: Glasenapp and colleagues determine whether inflammation can be serially imaged with 18F-FDG PET in early stages of pressure-overload–induced heart failure and compare the time course with functional impairment assessed by cardiac MRI.
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Prediction of conversion to AD: Blazhenets and colleagues examine the predictive values of amyloid PET, 18F-FDG PET, and nonimaging predictors (alone and in combination) for development of Alzheimer dementia in a large population of patients with mild cognitive impairment.
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TSPO versus P2X7 for neuroinflammation: Van Weehaeghe and colleagues compare imaging with 18F-DPA714, a second-generation translocator protein tracer, with 11C-JNJ717, a novel P2X7 receptor tracer, in vitro and in vivo in amyotrophic lateral sclerosis.
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Dose–response in 166Ho radioembolization: Bastiaannet and colleagues investigate the absorbed dose–response relationship and its association with overall survival for 166Ho-microsphere radioembolization in patients with liver metastases.
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Oral administration of 18F-FDG: Srinivasan and colleagues compare human biodistribution and dosimetry for 18F-FDG after sequential oral and intravenous administrations in the same subjects to determine dosimetry and potential suitability of oral 18F-FDG as an alternative to intravenous administration.
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- © 2020 by the Society of Nuclear Medicine and Molecular Imaging.