Alteration of Cellular Reduction Potential Will Change 64Cu-ATSM Signal With or Without Hypoxia

John M. Floberg; Lingjue Wang; Nilantha Bandara; Ramachandran Rashmi; Cedric Mpoy; Joel R. Garbow; Buck E. Rogers; Gary J. Patti; Julie K. Schwarz

doi:10.2967/jnumed.119.230805

Research ArticleMolecular Imaging

Alteration of Cellular Reduction Potential Will Change ⁶⁴Cu-ATSM Signal With or Without Hypoxia

John M. Floberg, Lingjue Wang, Nilantha Bandara, Ramachandran Rashmi, Cedric Mpoy, Joel R. Garbow, Buck E. Rogers, Gary J. Patti and Julie K. Schwarz

Journal of Nuclear Medicine March 2020, 61 (3) 427-432; DOI: https://doi.org/10.2967/jnumed.119.230805

John M. Floberg

1Department of Radiation Oncology, Washington University, St. Louis, Missouri

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Lingjue Wang

2Department of Chemistry, Washington University, St. Louis, Missouri

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Nilantha Bandara

1Department of Radiation Oncology, Washington University, St. Louis, Missouri

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Ramachandran Rashmi

1Department of Radiation Oncology, Washington University, St. Louis, Missouri

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Cedric Mpoy

1Department of Radiation Oncology, Washington University, St. Louis, Missouri

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Joel R. Garbow

3Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri

4Alvin J. Siteman Cancer Center, Washington University, St. Louis, Missouri; and

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Buck E. Rogers

1Department of Radiation Oncology, Washington University, St. Louis, Missouri

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Gary J. Patti

2Department of Chemistry, Washington University, St. Louis, Missouri

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Julie K. Schwarz

1Department of Radiation Oncology, Washington University, St. Louis, Missouri

4Alvin J. Siteman Cancer Center, Washington University, St. Louis, Missouri; and

5Department of Cell Biology and Physiology, Washington University, St. Louis, Missouri

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Journal of Nuclear Medicine

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March 1, 2020

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Alteration of Cellular Reduction Potential Will Change ⁶⁴Cu-ATSM Signal With or Without Hypoxia

John M. Floberg, Lingjue Wang, Nilantha Bandara, Ramachandran Rashmi, Cedric Mpoy, Joel R. Garbow, Buck E. Rogers, Gary J. Patti, Julie K. Schwarz

Journal of Nuclear Medicine Mar 2020, 61 (3) 427-432; DOI: 10.2967/jnumed.119.230805

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Alteration of Cellular Reduction Potential Will Change ⁶⁴Cu-ATSM Signal With or Without Hypoxia

John M. Floberg, Lingjue Wang, Nilantha Bandara, Ramachandran Rashmi, Cedric Mpoy, Joel R. Garbow, Buck E. Rogers, Gary J. Patti, Julie K. Schwarz

Journal of Nuclear Medicine Mar 2020, 61 (3) 427-432; DOI: 10.2967/jnumed.119.230805

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Keywords

Cu-ATSM
Redox
PET
hypoxia
cervical cancer

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