First-in-Humans Trial of Dasatinib-Derivative Tracer for Tumor Kinase-Targeted PET

Simone Krebs; Darren R. Veach; Lukas M. Carter; Milan Grkovski; Monica Fornier; Michael J. Mauro; Martin H. Voss; Daniel C. Danila; Eva Burnazi; Manda Null; Kevin Staton; Christina Pressl; Bradley J. Beattie; Pat Zanzonico; Wolfgang A. Weber; Serge K. Lyashchenko; Jason S. Lewis; Steven M. Larson; Mark P.S. Dunphy

doi:10.2967/jnumed.119.234864

Research ArticleOncology

First-in-Humans Trial of Dasatinib-Derivative Tracer for Tumor Kinase-Targeted PET

Simone Krebs, Darren R. Veach, Lukas M. Carter, Milan Grkovski, Monica Fornier, Michael J. Mauro, Martin H. Voss, Daniel C. Danila, Eva Burnazi, Manda Null, Kevin Staton, Christina Pressl, Bradley J. Beattie, Pat Zanzonico, Wolfgang A. Weber, Serge K. Lyashchenko, Jason S. Lewis, Steven M. Larson and Mark P.S. Dunphy

Journal of Nuclear Medicine November 2020, 61 (11) 1580-1587; DOI: https://doi.org/10.2967/jnumed.119.234864

Simone Krebs

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

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Darren R. Veach

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

2Department of Radiology, Weill Cornell Medicine, New York, New York

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Lukas M. Carter

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

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Milan Grkovski

3Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York

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Monica Fornier

4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York

5Department of Medicine, Weill Cornell Medicine, New York, New York

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Michael J. Mauro

4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York

5Department of Medicine, Weill Cornell Medicine, New York, New York

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Martin H. Voss

4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York

5Department of Medicine, Weill Cornell Medicine, New York, New York

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Daniel C. Danila

4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York

5Department of Medicine, Weill Cornell Medicine, New York, New York

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Eva Burnazi

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

6Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York

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Manda Null

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

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Kevin Staton

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

6Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York

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Christina Pressl

7Laboratory of Neural Systems, Rockefeller University, New York, New York

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Bradley J. Beattie

3Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York

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Pat Zanzonico

3Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York

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Wolfgang A. Weber

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

2Department of Radiology, Weill Cornell Medicine, New York, New York

8Department of Nuclear Medicine, Technical University of Munich, Munich, Germany; and

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Serge K. Lyashchenko

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

2Department of Radiology, Weill Cornell Medicine, New York, New York

6Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York

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Jason S. Lewis

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

2Department of Radiology, Weill Cornell Medicine, New York, New York

6Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York

9Molecular Pharmacology Program, Sloan Kettering Institute, New York, New York

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Steven M. Larson

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

2Department of Radiology, Weill Cornell Medicine, New York, New York

9Molecular Pharmacology Program, Sloan Kettering Institute, New York, New York

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Mark P.S. Dunphy

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

2Department of Radiology, Weill Cornell Medicine, New York, New York

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First-in-Humans Trial of Dasatinib-Derivative Tracer for Tumor Kinase-Targeted PET

Journal of Nuclear Medicine Nov 2020, 61 (11) 1580-1587; DOI: 10.2967/jnumed.119.234864

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First-in-Humans Trial of Dasatinib-Derivative Tracer for Tumor Kinase-Targeted PET

Journal of Nuclear Medicine Nov 2020, 61 (11) 1580-1587; DOI: 10.2967/jnumed.119.234864

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Keywords

18F-SKI-249380
Dasatinib
PET imaging
Src kinase

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