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Journal of Nuclear Medicine

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Table of Contents

November 1, 2020; Volume 61,Issue 11

This Month in JNM

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    This Month in JNM
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 14A;

Discussions with Leaders

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    20 Years of PET/CT: A Conversation with David Townsend and Thomas Beyer
    David Townsend, Thomas Beyer and Johannes Czernin
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 1541-1543; DOI: https://doi.org/10.2967/jnumed.120.257725

The State of the Art

  • Open Access
    Combination Strategies to Improve Targeted Radionuclide Therapy
    Tiffany G. Chan, Edward O’Neill, Christine Habjan and Bart Cornelissen
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 1544-1552; DOI: https://doi.org/10.2967/jnumed.120.248062

Continuing Education

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    Imaging the Cancer Immune Environment and Its Response to Pharmacologic Intervention, Part 2: The Role of Novel PET Agents
    Amir Iravani and Rodney J. Hicks
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 1553-1559; DOI: https://doi.org/10.2967/jnumed.120.248823

Oncology

  • Clinical

    • Prognostic Value of <sup>18</sup>F-FDG PET/CT in a Large Cohort of Patients with Advanced Metastatic Neuroendocrine Neoplasms Treated with Peptide Receptor Radionuclide Therapy
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      Prognostic Value of 18F-FDG PET/CT in a Large Cohort of Patients with Advanced Metastatic Neuroendocrine Neoplasms Treated with Peptide Receptor Radionuclide Therapy
      Jingjing Zhang, Qingxing Liu, Aviral Singh, Christiane Schuchardt, Harshad R. Kulkarni and Richard P. Baum
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1560-1569; DOI: https://doi.org/10.2967/jnumed.119.241414
    • <sup>18</sup>F-FDG PET Assessment of Malignant Pleural Mesothelioma: Total Lesion Volume and Total Lesion Glycolysis—The Central Role of Volume
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      18F-FDG PET Assessment of Malignant Pleural Mesothelioma: Total Lesion Volume and Total Lesion Glycolysis—The Central Role of Volume
      James C. Reynolds, Roberto Maass-Moreno, Anish Thomas, Alexander Ling, Emerson B. Padiernos, Seth M. Steinberg and Raffit Hassan
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1570-1575; DOI: https://doi.org/10.2967/jnumed.119.238733
    • BRIEF COMMUNICATION

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        PET Imaging Quantifying 68Ga-PSMA-11 Uptake in Metastatic Colorectal Cancer
        Tahleesa J. Cuda, Andrew D. Riddell, Cheng Liu, Vicki L. Whitehall, Jennifer Borowsky, David K. Wyld, Matthew E. Burge, Elizabeth Ahern, Alison Griffin, Nicholas J.R. Lyons, Stephen E. Rose, David A. Clark, Andrew R.L. Stevenson, John D. Hooper, Simon Puttick and Paul A. Thomas
        Journal of Nuclear Medicine November 1, 2020, 61 (11) 1576-1579; DOI: https://doi.org/10.2967/jnumed.119.233312
    • First-in-Humans Trial of Dasatinib-Derivative Tracer for Tumor Kinase-Targeted PET
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      First-in-Humans Trial of Dasatinib-Derivative Tracer for Tumor Kinase-Targeted PET
      Simone Krebs, Darren R. Veach, Lukas M. Carter, Milan Grkovski, Monica Fornier, Michael J. Mauro, Martin H. Voss, Daniel C. Danila, Eva Burnazi, Manda Null, Kevin Staton, Christina Pressl, Bradley J. Beattie, Pat Zanzonico, Wolfgang A. Weber, Serge K. Lyashchenko, Jason S. Lewis, Steven M. Larson and Mark P.S. Dunphy
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1580-1587; DOI: https://doi.org/10.2967/jnumed.119.234864
  • Basic

    • FEATURED BASIC SCIENCE ARTICLE

      • Open Access
        Receptor-Targeted Photodynamic Therapy of Glucagon-Like Peptide 1 Receptor–Positive Lesions
        Marti Boss, Desiree Bos, Cathelijne Frielink, Gerwin Sandker, Patricia Bronkhorst, Sanne A.M. van Lith, Maarten Brom, Mijke Buitinga and Martin Gotthardt
        Journal of Nuclear Medicine November 1, 2020, 61 (11) 1588-1593; DOI: https://doi.org/10.2967/jnumed.119.238998
    • The Biodistribution of a CD3 and EpCAM Bispecific T-Cell Engager Is Driven by the CD3 Arm
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      The Biodistribution of a CD3 and EpCAM Bispecific T-Cell Engager Is Driven by the CD3 Arm
      Frans V. Suurs, Grit Lorenczewski, Sabine Stienen, Matthias Friedrich, Elisabeth G.E. de Vries, Derk Jan A. de Groot and Marjolijn N. Lub-de Hooge
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1594-1601; DOI: https://doi.org/10.2967/jnumed.120.241877

Theranostics

  • Clinical

    • BRIEF COMMUNICATION

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        Neuroendocrine Differentiation and Response to PSMA-Targeted Radioligand Therapy in Advanced Metastatic Castration-Resistant Prostate Cancer: A Single-Center Retrospective Study
        Thorsten Derlin, Rudolf A. Werner, Marcel Lafos, Christoph Henkenberens, Christoph A.J. von Klot, Jan M. Sommerlath Sohns, Tobias L. Ross and Frank M. Bengel
        Journal of Nuclear Medicine November 1, 2020, 61 (11) 1602-1606; DOI: https://doi.org/10.2967/jnumed.120.241588
    • <sup>68</sup>Ga-PSMA–Guided Bone Biopsies for Molecular Diagnostics in Patients with Metastatic Prostate Cancer
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      68Ga-PSMA–Guided Bone Biopsies for Molecular Diagnostics in Patients with Metastatic Prostate Cancer
      Anouk C. de Jong, Minke Smits, Job van Riet, Jurgen J. Fütterer, Tessa Brabander, Paul Hamberg, Inge M. van Oort, Ronald de Wit, Martijn P. Lolkema, Niven Mehra, Marcel Segbers and Astrid A.M. van der Veldt
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1607-1614; DOI: https://doi.org/10.2967/jnumed.119.241109
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      18F-DCFPyL PET/CT in Patients with Subclinical Recurrence of Prostate Cancer: Effect of Lesion Size, Smoothing Filter, and Partial-Volume Correction on PROMISE Criteria
      Claudia Ortega, Josh Schaefferkoetter, Patrick Veit-Haibach, Reut Anconina, Alejandro Berlin, Nathan Perlis and Ur Metser
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1615-1620; DOI: https://doi.org/10.2967/jnumed.120.241737

Neurology

  • Clinical

    • FEATURED ARTICLE OF THE MONTH

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        Moving Toward Multicenter Therapeutic Trials in Amyotrophic Lateral Sclerosis: Feasibility of Data Pooling Using Different Translocator Protein PET Radioligands
        Donatienne Van Weehaeghe, Suma Babu, Joke De Vocht, Nicole R. Zürcher, Sheena Chew, Chieh-En J. Tseng, Marco L. Loggia, Michel Koole, Ahmadreza Rezaei, Georg Schramm, Philip Van Damme, Jacob M. Hooker, Koen Van Laere and Nazem Atassi
        Journal of Nuclear Medicine November 1, 2020, 61 (11) 1621-1627; DOI: https://doi.org/10.2967/jnumed.119.241059
    • Confirmation of <sup>123</sup>I-FP-CIT SPECT Quantification Methods in Dementia with Lewy Bodies and Other Neurodegenerative Disorders
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      Confirmation of 123I-FP-CIT SPECT Quantification Methods in Dementia with Lewy Bodies and Other Neurodegenerative Disorders
      Daniela D. Maltais, Lennon G. Jordan, Hoon-Ki Min, Toji Miyagawa, Scott A. Przybelski, Timothy G. Lesnick, Robert R. Reichard, Dennis W. Dickson, Melissa E. Murray, Kejal Kantarci, Bradley F. Boeve and Val J. Lowe
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1628-1635; DOI: https://doi.org/10.2967/jnumed.119.239418
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      Kinetic Modeling and Test–Retest Reproducibility of 11C-EKAP and 11C-FEKAP, Novel Agonist Radiotracers for PET Imaging of the κ-Opioid Receptor in Humans
      Mika Naganawa, Songye Li, Nabeel Nabulsi, Shu-fei Lin, David Labaree, Jim Ropchan, Hong Gao, Michael Mei, Shannan Henry, David Matuskey, Richard E. Carson and Yiyun Huang
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1636-1642; DOI: https://doi.org/10.2967/jnumed.119.227694

Cardiovascular

  • Basic

    • Folate Receptor β–Targeted PET Imaging of Macrophages in Autoimmune Myocarditis
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      Folate Receptor β–Targeted PET Imaging of Macrophages in Autoimmune Myocarditis
      Arghavan Jahandideh, Sauli Uotila, Mia Ståhle, Jenni Virta, Xiang-Guo Li, Ville Kytö, Päivi Marjamäki, Heidi Liljenbäck, Pekka Taimen, Vesa Oikonen, Jukka Lehtonen, Mikko I. Mäyränpää, Qingshou Chen, Philip S. Low, Juhani Knuuti, Anne Roivainen and Antti Saraste
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1643-1649; DOI: https://doi.org/10.2967/jnumed.119.241356

Pulmonary

  • Basic

    • Assessing the Activity of Multidrug Resistance–Associated Protein 1 at the Lung Epithelial Barrier
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      Assessing the Activity of Multidrug Resistance–Associated Protein 1 at the Lung Epithelial Barrier
      Severin Mairinger, Johannes A. Sake, Irene Hernández Lozano, Thomas Filip, Michael Sauberer, Johann Stanek, Thomas Wanek, Carsten Ehrhardt and Oliver Langer
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1650-1657; DOI: https://doi.org/10.2967/jnumed.120.244038

Dosimetry

  • Clinical

    • The Impact of Radiobiologically Informed Dose Prescription on the Clinical Benefit of <sup>90</sup>Y SIRT in Colorectal Cancer Patients
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      The Impact of Radiobiologically Informed Dose Prescription on the Clinical Benefit of 90Y SIRT in Colorectal Cancer Patients
      Elliot M. Abbott, Nadia Falzone, Boon Q. Lee, Christiana Kartsonaki, Helen Winter, Tessa A. Greenhalgh, Daniel R. McGowan, Nigar Syed, Ana M. Denis-Bacelar, Philip Boardman, Ricky A. Sharma and Katherine A. Vallis
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1658-1664; DOI: https://doi.org/10.2967/jnumed.119.233650

Genitourinary

  • Translational

    • <sup>11</sup>C-PABA as a PET Radiotracer for Functional Renal Imaging: Preclinical and First-in-Human Study
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      11C-PABA as a PET Radiotracer for Functional Renal Imaging: Preclinical and First-in-Human Study
      Camilo A. Ruiz-Bedoya, Alvaro A. Ordonez, Rudolf A. Werner, Donika Plyku, Mariah H. Klunk, Jeff Leal, Wojciech G. Lesniak, Daniel P. Holt, Robert F. Dannals, Takahiro Higuchi, Steven P. Rowe and Sanjay K. Jain
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1665-1671; DOI: https://doi.org/10.2967/jnumed.119.239806

Molecular Imaging

  • Clinical

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      PET Imaging of Phosphodiesterase-4 Identifies Affected Dysplastic Bone in McCune–Albright Syndrome, a Genetic Mosaic Disorder
      Lora D. Weidner, Yuichi Wakabayashi, Louise A. Stolz, Michael T. Collins, Lori Guthrie, Milalynn Victorino, Joyce Chung, William Miller, Sami S. Zoghbi, Victor W. Pike, Masahiro Fujita, Robert B. Innis and Alison M. Boyce
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1672-1677; DOI: https://doi.org/10.2967/jnumed.120.241976

Physics and Instrumentation

  • Clinical

    • Data-Driven Respiratory Gating Outperforms Device-Based Gating for Clinical <sup>18</sup>F-FDG PET/CT
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      Data-Driven Respiratory Gating Outperforms Device-Based Gating for Clinical 18F-FDG PET/CT
      Matthew D. Walker, Andrew J. Morgan, Kevin M. Bradley and Daniel R. McGowan
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1678-1683; DOI: https://doi.org/10.2967/jnumed.120.242248
  • Basic

    • You have access
      Benefit of Improved Performance with State-of-the Art Digital PET/CT for Lesion Detection in Oncology
      Suleman Surti, Varsha Viswanath, Margaret E. Daube-Witherspoon, Maurizio Conti, Michael E. Casey and Joel S. Karp
      Journal of Nuclear Medicine November 1, 2020, 61 (11) 1684-1690; DOI: https://doi.org/10.2967/jnumed.120.242305

Letters to the Editor

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    3D-Printable Platform for High-Throughput Small-Animal Imaging
    Lukas M. Carter, Kelly E. Henry, Andre Platzman and Jason S. Lewis
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 1691-1692; DOI: https://doi.org/10.2967/jnumed.119.240457
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    11C-(+)-PHNO Trapping Reversibility for Quantitative PET Imaging of β-Cell Mass in Patients with Type 1 Diabetes
    Eric Laffon and Roger Marthan
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 1692-1693; DOI: https://doi.org/10.2967/jnumed.119.241075
  • You have access
    Reply: 11C-(+)-PHNO Trapping Reversibility for Quantitative PET Imaging of β-Cell Mass in Patients with Type 1 Diabetes
    Jason Bini, Richard E. Carson and Gary W. Cline
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 1693; DOI: https://doi.org/10.2967/jnumed.120.250985
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    Interim PET Assessment of Advanced Hodgkin Lymphoma: Is It Sufficient?
    Charles Mesguich, Krimo Bouabdallah, Laurence Bordenave, Noël Milpied and Elif Hindié
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 1694-1695; DOI: https://doi.org/10.2967/jnumed.120.242594
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    Reply: Interim PET Assessment of Advanced Hodgkin Lymphoma: Is It Sufficient?
    Deborah M. Stephens, Heiko Schoder, Hongli Li and Jonathan Friedberg
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 1695; DOI: https://doi.org/10.2967/jnumed.120.242685

SNMMI Newsline

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    SNMMI Newsline
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 15N-26N;
  • You have access
    2020 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging
    Mehran M. Sadeghi
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 15N-22N;
  • You have access
    SNMMI Leadership Update: Research—The Key to Nuclear Medicine’s Past and Future
    Alan B. Packard
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 23N;
  • You have access
    NRC and Regulatory Relief for Training for Imaging/Localization Studies
    Journal of Nuclear Medicine November 1, 2020, 61 (11) 24N-26N;
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In this issue

Journal of Nuclear Medicine: 61 (11)
Journal of Nuclear Medicine
Vol. 61, Issue 11
November 1, 2020
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author

Issue highlights

  • Moving Toward Multicenter Therapeutic Trials in Amyotrophic Lateral Sclerosis: Feasibility of Data Pooling Using Different Translocator Protein PET Radioligands
  • 11C-PABA as a PET Radiotracer for Functional Renal Imaging: Preclinical and First-in-Human Study
  • PET Imaging of Phosphodiesterase-4 Identifies Affected Dysplastic Bone in McCune–Albright Syndrome, a Genetic Mosaic Disorder
  • Data-Driven Respiratory Gating Outperforms Device-Based Gating for Clinical 18F-FDG PET/CT
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      • BRIEF COMMUNICATION
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      • FEATURED BASIC SCIENCE ARTICLE
  • Theranostics
    • Clinical
      • BRIEF COMMUNICATION
  • Neurology
    • Clinical
      • FEATURED ARTICLE OF THE MONTH
  • Cardiovascular
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    • Clinical
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  • 68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer
  • Deep Learning Analysis of Upright-Supine High-Efficiency SPECT Myocardial Perfusion Imaging for Prediction of Obstructive Coronary Artery Disease: A Multicenter Study
  • Incidental Findings Suggestive of COVID-19 in Asymptomatic Patients Undergoing Nuclear Medicine Procedures in a High-Prevalence Region
  • Development of Fibroblast Activation Protein–Targeted Radiotracers with Improved Tumor Retention
  • Diagnostic Evaluation of Pulmonary Embolism During the COVID-19 Pandemic
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