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Estimation of radiation doses to patients from nuclear medicine examinations in a Chinese hospital

Feng Wang and Zhi Yang
Journal of Nuclear Medicine May 2019, 60 (supplement 1) 3044;

Abstract

3044

Purpose: In china, there is a quick increasing quantity of nuclear medicine examinations, which people concern the radiation risk from the exposure very much. The aim of this study was to calculate and estimate the radiation doses of patients undergoing nuclear medicine examinations. Materials and Methods: Patients undergoing nuclear medicine examinations were classified by the Positron Emission Tomography-Computed Tomography (PET/CT; Philips/Gemini TF) and Single Photon Emission Computed Tomography (SPECT; Siemens/eCam). The effective dose from radiopharmaceuticals to patients was measured and calculated by multiplying the mean activity and the coefficient as illustrated in ICRP report (ICRP 53 1988, ICRP 80 1998, ICRP 106 2008). Meanwhile, effective dose from Computed Tomography (CT) in the PET/CT examination was calculated by the empirical formula from ICRP report (ICRP 102 2007).

Results: The average effective dose of patients irradiated from positron radiopharmaceuticals 18F-fluorodeoxyglucose(18F-FDG), 18F-fluoro-l-thymidine (18F-FLT), 11C-choline, 11C-methylmethionine (11C-MET) and 11C-acetate (11C-Ac) was (5.06±0.73), (4.74±1.30), (1.71±0.22), (3.18±0.70) and (1.08±0.20) mSv, respectively. Low-dose CT scan produces average (8.80±0.58) mSv effective doses with regular PET/CT examination. If a full diagnostic CT or a delay imaging was performed, the effective dose might increase 14 or 5 mSv additionally. Whereas for SPECT examinations, the average effective dose of patients irradiated from single photon radiopharmaceutical 99mTc-methylenediphosphonate (99mTc-MDP), 99mTc-macroaggregated albumin (99mTc-MAA), 99mTc-diethylentriaminpentaacetic acid (99mTc-DTPA), 99mTc-methoxyisobutyl isonitrile (99mTc-MIBI) and 99mTc-Pyrophosphate (99mTc-PYP) was (4.33±0.01), (1.71±0.01), (1.18±0.01), (7.19±0.03) and (4.18±0.02) mSv, respectively. Conclusions Effective dose of patients undergoing nuclear medicine examinations caused by radiopharmaceutical irradiation was from (1.08±0.20) to (7.19±0.03) mSv while CT scan produced average effective dose (8.80 ± 0.58) mSv in regular PET/CT examination. It is necessary to optimize the CT parameters to reduce the radiation dose as soon as possible.[Keywords] PET/CT;SPECT;Radiation;Absorbed dose;Nuclear medicine

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Journal of Nuclear Medicine
Vol. 60, Issue supplement 1
May 1, 2019
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