Article Figures & Data
Figures
- FIGURE 1.
Chemical structure of 18F-DMFB.
- FIGURE 2.
(A) In vitro binding of 18F-DMFB to 2 mg of melanin at 37°C for 10, 30, 60, and 120 min. (B) In vitro uptake of 18F-DMFB by B16F10 cells in presence and absence of l-tyrosine at 10, 30, and 60 min, including photograph of B16F10 cell pellets in absence (left) and presence (right) of l-tyrosine.
- FIGURE 3.
(A) PET images of mice bearing B16F10 at 10, 30, and 60 min after injection of 18F-DMFB. (B and C) PET images of mice bearing B16F10 and CT26 (B) and B16F10 and U87MG (C) at 60 min after injection of 18F-DMFB (white arrow, B16F10; yellow arrow, CT26; red arrow, U87MG).
- FIGURE 4.
(A and B) Maximum-intensity-projection (top) and transaxial (bottom) images of normal (A) and lung metastasis (B) model (C57BL/6) at 60 min after injection of 18F-DMFB. (C) Coronal PET image of B16F10 liver metastasis model (Foxn1nu) at 60 min after injection of 18F-DMFB.
- FIGURE 5.
(A) Photograph of B16F10 LN metastasis model. (B) PET, CT, and PET/CT images of B16F10 LN metastasis model at 60 min after injection of 18F-DMFB. (C) Photomicrographs of LN metastasis. (White arrows, LN metastasis region.)
- FIGURE 6.
PET imaging of 18F-FDG and 18F-DMFB in mouse models. (A) Coronal images in mice bearing B16F10 at 60 min after injection. (B) Maximum-intensity-projection (top) and transaxial (bottom) images of lung metastasis model at 60 min after injection. mets = metastases.
Tables
- TABLE 1
Biodistribution of 18F-DMFB in Foxn1nu Mice Bearing B16F10 After Intravenous Injection
Site 10 min 30 min 60 min 120 min Blood 5.26 ± 1.02 3.20 ± 0.51 0.98 ± 0.26 0.16 ± 0.006 Heart 6.22 ± 0.91 3.07 ± 0.17 1.20 ± 0.38 0.20 ± 0.024 Lung 11.66 ± 2.91 4.57 ± 0.65 1.89 ± 0.63 0.33 ± 0.031 Liver 11.19 ± 0.62 5.76 ± 0.41 2.47 ± 1.05 0.45 ± 0.06 Spleen 13.19 ± 2.58 5.88 ± 0.83 2.23 ± 0.92 0.34 ± 0.12 Stomach 9.01 ± 4.51 6.49 ± 2.35 2.87 ± 0.29 0.82 ± 0.64 Intestine 12.54 ± 1.56 7.88 ± 0.82 2.65 ± 0.80 0.52 ± 0.09 Kidney 40.42 ± 14.69 16.74 ± 4.91 5.08 ± 1.69 0.93 ± 0.29 Pancreas 10.03 ± 3.20 4.73 ± 0.62 1.77 ± 0.78 0.20 ± 0.05 Muscle 5.67 ± 0.60 3.36 ± 1.68 1.44 ± 0.11 0.34 ± 0.12 Bone 5.07 ± 0.38 2.40 ± 0.40 1.03 ± 0.47 0 Brain 6.84 ± 1.02 2.96 ± 0.61 1.21 ± 0.70 0.26 ± 0.08 Skin 7.73 ± 1.63 3.94 ± 1.73 1.96 ± 0.32 0.37 ± 0.07 Eyes 4.26 ± 0.50 2.79 ± 0.71 1.05 ± 0.07 0.04 ± 0.02 Tumor 9.24 ± 2.23 10.80 ± 3.27 13.00 ± 3.90 10.59 ± 1.35 Data are %ID/g ± SD (n = 3/time point).
Supplemental Data
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