A Single Dose of 225Ac-RPS-074 Induces a Complete Tumor Response in an LNCaP Xenograft Model

James M. Kelly; Alejandro Amor-Coarasa; Shashikanth Ponnala; Anastasia Nikolopoulou; Clarence Williams; Nikki A. Thiele; David Schlyer; Justin J. Wilson; Stephen G. DiMagno; John W. Babich

doi:10.2967/jnumed.118.219592

Research ArticleTheranostics

A Single Dose of ²²⁵Ac-RPS-074 Induces a Complete Tumor Response in an LNCaP Xenograft Model

James M. Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, Nikki A. Thiele, David Schlyer, Justin J. Wilson, Stephen G. DiMagno and John W. Babich

Journal of Nuclear Medicine May 2019, 60 (5) 649-655; DOI: https://doi.org/10.2967/jnumed.118.219592

James M. Kelly

1Division of Radiopharmaceutical Science, Department of Radiology, Weill Cornell Medicine, New York, New York

2Molecular Imaging Innovations Institute (MI3), Department of Radiology, Weill Cornell Medicine, New York, New York

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Alejandro Amor-Coarasa

1Division of Radiopharmaceutical Science, Department of Radiology, Weill Cornell Medicine, New York, New York

2Molecular Imaging Innovations Institute (MI3), Department of Radiology, Weill Cornell Medicine, New York, New York

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Shashikanth Ponnala

1Division of Radiopharmaceutical Science, Department of Radiology, Weill Cornell Medicine, New York, New York

2Molecular Imaging Innovations Institute (MI3), Department of Radiology, Weill Cornell Medicine, New York, New York

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Anastasia Nikolopoulou

1Division of Radiopharmaceutical Science, Department of Radiology, Weill Cornell Medicine, New York, New York

3Citigroup Biomedical Imaging Center, Weill Cornell Medicine, New York, New York

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Clarence Williams Jr.

1Division of Radiopharmaceutical Science, Department of Radiology, Weill Cornell Medicine, New York, New York

2Molecular Imaging Innovations Institute (MI3), Department of Radiology, Weill Cornell Medicine, New York, New York

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Nikki A. Thiele

4Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York

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David Schlyer

5Brookhaven National Laboratory, Upton, New York

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Justin J. Wilson

4Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York

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Stephen G. DiMagno

6College of Pharmacy, University of Illinois–Chicago, Chicago, Illinois; and

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John W. Babich

1Division of Radiopharmaceutical Science, Department of Radiology, Weill Cornell Medicine, New York, New York

2Molecular Imaging Innovations Institute (MI3), Department of Radiology, Weill Cornell Medicine, New York, New York

3Citigroup Biomedical Imaging Center, Weill Cornell Medicine, New York, New York

7Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York

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Journal of Nuclear Medicine

Vol. 60, Issue 5

May 1, 2019

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A Single Dose of ²²⁵Ac-RPS-074 Induces a Complete Tumor Response in an LNCaP Xenograft Model

James M. Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, Nikki A. Thiele, David Schlyer, Justin J. Wilson, Stephen G. DiMagno, John W. Babich

Journal of Nuclear Medicine May 2019, 60 (5) 649-655; DOI: 10.2967/jnumed.118.219592

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A Single Dose of ²²⁵Ac-RPS-074 Induces a Complete Tumor Response in an LNCaP Xenograft Model

James M. Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, Nikki A. Thiele, David Schlyer, Justin J. Wilson, Stephen G. DiMagno, John W. Babich

Journal of Nuclear Medicine May 2019, 60 (5) 649-655; DOI: 10.2967/jnumed.118.219592

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Keywords

targeted alpha therapy
225Ac
PSMA
complete tumor response

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A Single Dose of ²²⁵Ac-RPS-074 Induces a Complete Tumor Response in an LNCaP Xenograft Model

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