Article Figures & Data
Figures
- FIGURE 1.
A 56-y-old patient with a leiomyosarcoma of the left limb (arrows). The tumor manifestation does not show significant changes in tumor size (diameter: from 243 to 256 mm), contrast-enhancing tumor parts and metabolic activity (SUVpeak: from 3.9 to 3.6). Histopathologic analysis revealed a regression grade 5 (histopathologic nonresponder).
- FIGURE 2.
Receiver-operating-characteristic curves of ratings according to RECIST, Choi criteria, and PERCIST.
- FIGURE 3.
A 60-y-old patient with an undifferentiated pleomorphic sarcoma of the right limb (arrows). The tumor reveals an extensive tumor necrosis and a significant reduction of 18F-FDG uptake (SUVpeak: from 15.3 to 4.1) between pre- (A–C) and posttherapeutic (D–F) examinations, whereas tumor size remains substantially stable (diameter: from 99 to 97 mm). Histopathologic analysis revealed a regression grade 3 (histopathologic responder).
- FIGURE 4.
Receiver-operating-characteristic curves of quantitative variables for assessment of therapeutic response to ILP.
Tables
Histologic subtype Patients (n) Undifferentiated pleomorphic sarcoma 9 Synovial sarcoma 9 Undifferentiated spindle cell sarcoma 8 Myxofibrosarcoma 7 Liposarcoma 4 Epitheloid sarcoma 2 Leiomyosarcoma 2 Clear cell sarcoma 1 Angiosarcoma 1 Fibrosarcoma 1 Malignant peripheral nerve sheath tumor 1 Total 45 - TABLE 2
Tumor Grades of All Patients, According to 6-Stage Salzer-Kuntschik Regression Scale
Tumor grade Patients (n) I 6 II 8 III 13 IV 10 V 7 VI 1 - TABLE 3
Sensitivity, Specificity, Positive Predictive Value, Negative Predictive Value, Diagnostic Accuracy, and AUC of the 3 Response Criteria for Differentiation Between Responders and Nonresponders
Response criteria Sensitivity Specificity Positive predictive value Negative predictive value Accuracy AUC RECIST 22.2% 88.9% 75.0% 43.2% 48.9% 0.556 Choi criteria 70.4% 44.4% 65.5% 50.0% 60.0% 0.574 PERCIST 85.2% 77.8% 85.2% 77.8% 82.2% 0.815
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