Diastereomerically Pure 6R- and 6S-3′-Aza-2′-18F-Fluoro-5-Methyltetrahydrofolates Show Unprecedentedly High Uptake in Folate Receptor–Positive KB Tumors

Silvan D. Boss; Cristina Müller; Klaudia Siwowska; Raffaella M. Schmid; Viola Groehn; Roger Schibli; Simon M. Ametamey

doi:10.2967/jnumed.118.213314

Research ArticleRadiochemistry

Diastereomerically Pure 6R- and 6S-3′-Aza-2′-¹⁸F-Fluoro-5-Methyltetrahydrofolates Show Unprecedentedly High Uptake in Folate Receptor–Positive KB Tumors

Silvan D. Boss, Cristina Müller, Klaudia Siwowska, Raffaella M. Schmid, Viola Groehn, Roger Schibli and Simon M. Ametamey

Journal of Nuclear Medicine January 2019, 60 (1) 135-141; DOI: https://doi.org/10.2967/jnumed.118.213314

Silvan D. Boss

1Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Cristina Müller

2Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institut, Villigen-PSI, Switzerland; and

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Klaudia Siwowska

2Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institut, Villigen-PSI, Switzerland; and

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Raffaella M. Schmid

2Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institut, Villigen-PSI, Switzerland; and

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Viola Groehn

3Merck & Cie, Schaffhausen, Switzerland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Roger Schibli

1Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

2Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institut, Villigen-PSI, Switzerland; and

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Simon M. Ametamey

1Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Article
Figures & Data
Supplemental
Info & Metrics
PDF

Data supplements

Supplemental Data

Files in this Data Supplement:

Supplemental Data

PreviousNext

In this issue

Journal of Nuclear Medicine

Vol. 60, Issue 1

January 1, 2019

Table of Contents
Table of Contents (PDF)
About the Cover
Index by author

Download PDF

Article Alerts

User Name *

Password *

Email *

Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Diastereomerically Pure 6R- and 6S-3′-Aza-2′-18F-Fluoro-5-Methyltetrahydrofolates Show Unprecedentedly High Uptake in Folate Receptor–Positive KB Tumors

Message Subject (Your Name) has sent you a message from Journal of Nuclear Medicine

Message Body (Your Name) thought you would like to see the Journal of Nuclear Medicine web site.

Your Personal Message

Citation Tools

Diastereomerically Pure 6R- and 6S-3′-Aza-2′-¹⁸F-Fluoro-5-Methyltetrahydrofolates Show Unprecedentedly High Uptake in Folate Receptor–Positive KB Tumors

Silvan D. Boss, Cristina Müller, Klaudia Siwowska, Raffaella M. Schmid, Viola Groehn, Roger Schibli, Simon M. Ametamey

Journal of Nuclear Medicine Jan 2019, 60 (1) 135-141; DOI: 10.2967/jnumed.118.213314

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Diastereomerically Pure 6R- and 6S-3′-Aza-2′-¹⁸F-Fluoro-5-Methyltetrahydrofolates Show Unprecedentedly High Uptake in Folate Receptor–Positive KB Tumors

Silvan D. Boss, Cristina Müller, Klaudia Siwowska, Raffaella M. Schmid, Viola Groehn, Roger Schibli, Simon M. Ametamey

Journal of Nuclear Medicine Jan 2019, 60 (1) 135-141; DOI: 10.2967/jnumed.118.213314

Share This Article:

Tweet Widget
Facebook Like
Google Plus One

Bookmark this article

User Name *

Password *

Remember my user name & password.

Jump to section

Article
Figures & Data
Supplemental
Info & Metrics
PDF

This Month in JNM

PubMed
Google Scholar

Cited By...

Identification of a PET Radiotracer for Imaging of the Folate Receptor-{alpha}: A Potential Tool to Select Patients for Targeted Tumor Therapy

Google Scholar

Radiochemistry

Cyclotron-Produced ¹³²La as a PET Imaging Surrogate for Therapeutic ²²⁵Ac
Cyclotron Production and Separation of Scandium Radionuclides from Natural Titanium Metal and Titanium Dioxide Targets
Synthesis of the PET Tracer ¹²⁴I-Trametinib for MAPK/ERK Kinase Distribution and Resistance Monitoring

Show more Radiochemistry

Basic

Cyclotron-Produced ¹³²La as a PET Imaging Surrogate for Therapeutic ²²⁵Ac
Cyclotron Production and Separation of Scandium Radionuclides from Natural Titanium Metal and Titanium Dioxide Targets
Synthesis of the PET Tracer ¹²⁴I-Trametinib for MAPK/ERK Kinase Distribution and Resistance Monitoring

Show more Basic

Keywords

folate receptor
5-methyltetrahydrofolate
18F
PET
imaging

Main menu

User menu

Search

Diastereomerically Pure 6R- and 6S-3′-Aza-2′-¹⁸F-Fluoro-5-Methyltetrahydrofolates Show Unprecedentedly High Uptake in Folate Receptor–Positive KB Tumors

Data supplements

Supplemental Data

In this issue

Citation Manager Formats

Related Articles

Cited By...

More in this TOC Section

Radiochemistry

Basic

Similar Articles

Keywords