Abstract
1450
Objectives: maging is playing an increasingly important role in the detection of prostate cancer . Multiparametric ultrasound (US), multiparametric magnetic resonance imaging (MRI), MRI-US fusion imaging are playing a key role in detection of tumors with aspiration biopsies, But staging is not still clear which is biologically and clinically a heterogeneous disease that makes imaging evaluation challenging. We aimed to investigate the role of Ga-68 PSMA PET /CT in primary staging of prostate cancer. Material and Methods : All prostate cancer patients referred to our department for a a Ga-68 PSMA PET /CT scan for primary staging included to the study. Their available archived previous history, PSA values , Gleason scores and PET /CT results analysed, retrospectively Patients were divided to three groups up to their Gleason scores , Gleason score 6 was well differentiated Group, score 7 was moderately differentiated and 8-10 scores ere called poorly differentiated group. Results: Sixty two prostate cancer patients aging between 47 -85 (mean 69 ±6.13) . Their gleason score median value was 8 (ranging between 6 and 10), median PSA value was 17.22 (range 4.61-1064). In well differentiated group there were 8 patients and in moderately differentiated and poorly differentiated groups were including 13 and 30 patients , respectively In well differentiated group, Ga-68 PSMA PET/CT revealed , tumour in the primary site and a patient with metastatic regional lymph nodes and bone metastasis in two patients In the moderately differentiated group 2/13 patients had seminal vesicles invasion, 3/13 patients had regional lymph node metastasis and bone metastasis, another patient had bone metastasis without any pathological uptake in lymph nodes. Ga-68 PSMA PET/CT revealed a brain metastastis in a patient. In the third group with highest Gleason scores 2/30 patients had seminal vesicle invasion, 4/30 lymph node metastasis, 9 bone metastasis, a rectal invasion and a penile metastasis. Conclusion: The overall results suggest clinical utility of Ga68-PSMA scan in prostate cancer. The Ga68-PSMA scan had high sensitivity with histopathological diagnosis. The scan was able to detect distant metastasis even with low Gleason scores. Ga68 PSMA is a valuable tool for prostate cancer staging .