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Research ArticleOncology

Radioiodinated Small-Molecule Tyrosine Kinase Inhibitor for HER2-Selective SPECT Imaging

Longguang Tang, Chenyu Peng, Bowen Tang, Zijing Li, Xiangyu Wang, Jindian Li, Fei Gao, Lumei Huang, Duo Xu, Pu Zhang, Rongqiang Zhuang, Xinhui Su, Xiaoyuan Chen and Xianzhong Zhang
Journal of Nuclear Medicine September 2018, 59 (9) 1386-1391; DOI: https://doi.org/10.2967/jnumed.117.205088
Longguang Tang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
2Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, Maryland
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Chenyu Peng
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
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Bowen Tang
3School of Pharmaceutical Science, Xiamen University, Xiamen, China; and
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Zijing Li
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
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Xiangyu Wang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
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Jindian Li
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
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Fei Gao
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
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Lumei Huang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
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Duo Xu
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
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Pu Zhang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
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Rongqiang Zhuang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
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Xinhui Su
4Zhongshan Hospital, affiliated with Xiamen University, Xiamen, China
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Xiaoyuan Chen
2Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, Maryland
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Xianzhong Zhang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
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Article Information

vol. 59 no. 9 1386-1391
DOI 
https://doi.org/10.2967/jnumed.117.205088
PubMed 
29653973

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication November 9, 2017
  • Accepted for publication March 23, 2018
  • Published online September 4, 2018.

Article Versions

  • previous version (April 13, 2018 - 05:44).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2018 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Longguang Tang*,1,2,
  2. Chenyu Peng*,1,
  3. Bowen Tang3,
  4. Zijing Li1,
  5. Xiangyu Wang1,
  6. Jindian Li1,
  7. Fei Gao1,
  8. Lumei Huang1,
  9. Duo Xu1,
  10. Pu Zhang1,
  11. Rongqiang Zhuang1,
  12. Xinhui Su4,
  13. Xiaoyuan Chen2 and
  14. Xianzhong Zhang1
  1. 1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
  2. 2Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, Maryland
  3. 3School of Pharmaceutical Science, Xiamen University, Xiamen, China; and
  4. 4Zhongshan Hospital, affiliated with Xiamen University, Xiamen, China
  1. For correspondence or reprints contact: Xianzhong Zhang, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiang’an South Rd., Xiang’an District, Xiamen 361102, China. E-mail: zhangxzh{at}xmu.edu.cn
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 59 (9)
Journal of Nuclear Medicine
Vol. 59, Issue 9
September 1, 2018
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Radioiodinated Small-Molecule Tyrosine Kinase Inhibitor for HER2-Selective SPECT Imaging
Longguang Tang, Chenyu Peng, Bowen Tang, Zijing Li, Xiangyu Wang, Jindian Li, Fei Gao, Lumei Huang, Duo Xu, Pu Zhang, Rongqiang Zhuang, Xinhui Su, Xiaoyuan Chen, Xianzhong Zhang
Journal of Nuclear Medicine Sep 2018, 59 (9) 1386-1391; DOI: 10.2967/jnumed.117.205088

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Radioiodinated Small-Molecule Tyrosine Kinase Inhibitor for HER2-Selective SPECT Imaging
Longguang Tang, Chenyu Peng, Bowen Tang, Zijing Li, Xiangyu Wang, Jindian Li, Fei Gao, Lumei Huang, Duo Xu, Pu Zhang, Rongqiang Zhuang, Xinhui Su, Xiaoyuan Chen, Xianzhong Zhang
Journal of Nuclear Medicine Sep 2018, 59 (9) 1386-1391; DOI: 10.2967/jnumed.117.205088
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Keywords

  • HER2
  • tyrosine kinase inhibitor
  • radioiodinated IBA-CP
  • breast cancer
  • small-animal SPECT
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