Review ArticleContinuing Education

An Overview of PET Radiochemistry, Part 1: The Covalent Labels 18F, 11C, and 13N

Verena Pichler, Neydher Berroterán-Infante, Cecile Philippe, Chrysoula Vraka, Eva-Maria Klebermass, Theresa Balber, Sarah Pfaff, Lukas Nics, Markus Mitterhauser and Wolfgang Wadsak
Journal of Nuclear Medicine September 2018, 59 (9) 1350-1354; DOI: https://doi.org/10.2967/jnumed.117.190793

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Nuclear reactions of golden radionuclides.

  • FIGURE 2.
    FIGURE 2.

    Overview on different PET tracers with covalent radiolabel: [11C]methionine (A), O-(2-[18F]fluoroethyl)-l-tyrosine (B), 3,4-dihydroxy-6-[18F]fluoro-l-phenylalanine (C), 5-hydroxy-l-[β-11C]tryptophan (D), α-[11C]methyltryptophan (E), [18F]FDG (F), [13N]NH3 (G), [11C]PIB (H), [18F]flutemetamol (I), [18F]florbetaben (J), [18F]florbetapir (K), [11C]choline (L), [18F]fluoromethylcholine (M), [18F]fluoroethylcholine (N), [18F]PSMA-1007 (O), [11C]raclopride (P), and [18F]fallypride (Q).

  • FIGURE 3.
    FIGURE 3.

    Synthetic scheme of [18F]FDG radiosynthesis via nucleophilic substitution.

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