TY - JOUR T1 - An Overview of PET Radiochemistry, Part 1: The Covalent Labels <sup>18</sup>F, <sup>11</sup>C, and <sup>13</sup>N JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1350 LP - 1354 DO - 10.2967/jnumed.117.190793 VL - 59 IS - 9 AU - Verena Pichler AU - Neydher BerroterĂ¡n-Infante AU - Cecile Philippe AU - Chrysoula Vraka AU - Eva-Maria Klebermass AU - Theresa Balber AU - Sarah Pfaff AU - Lukas Nics AU - Markus Mitterhauser AU - Wolfgang Wadsak Y1 - 2018/09/01 UR - http://jnm.snmjournals.org/content/59/9/1350.abstract N2 - This continuing educational article introduces the radiochemistry of PET tracers that exhibit a covalently bound radiolabel with the nuclides 11C, 13N, and 18F. The overall process of PET tracer production is explained, starting from the production of the radionuclide in a cyclotron; followed by the automatization process of the radiosynthesis, including the necessary steps for the respective synthesis; and finalized with the requirements for quality control. ER -