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Journal of Nuclear Medicine

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Research ArticleOncology

Thymidine Metabolism as a Confounding Factor for 3′-Deoxy-3′-18F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model

Sonja Schelhaas, Lydia Wachsmuth, Sven Hermann, Natascha Rieder, Astrid Heller, Kathrin Heinzmann, Davina J. Honess, Donna-Michelle Smith, Inga B. Fricke, Nathalie Just, Sabrina Doblas, Ralph Sinkus, Christian Döring, Klaus P. Schäfers, John R. Griffiths, Cornelius Faber, Richard Schneider, Eric O. Aboagye and Andreas H. Jacobs
Journal of Nuclear Medicine July 2018, 59 (7) 1063-1069; DOI: https://doi.org/10.2967/jnumed.117.206250
Sonja Schelhaas
1European Institute for Molecular Imaging, Westfälische Wilhelms-Universität Münster, Münster, Germany
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Lydia Wachsmuth
2Department of Clinical Radiology, University Hospital of Münster, Münster, Germany
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Sven Hermann
1European Institute for Molecular Imaging, Westfälische Wilhelms-Universität Münster, Münster, Germany
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Natascha Rieder
3Pathology and Tissue Analytics, Roche Pharma Research and Early Development, Roche Innovation Center, Munich, Germany
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Astrid Heller
3Pathology and Tissue Analytics, Roche Pharma Research and Early Development, Roche Innovation Center, Munich, Germany
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Kathrin Heinzmann
4Comprehensive Cancer Imaging Centre, Imperial College London, London, United Kingdom
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Davina J. Honess
5Cancer Research U.K. Cambridge Institute, Cambridge, United Kingdom
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Donna-Michelle Smith
5Cancer Research U.K. Cambridge Institute, Cambridge, United Kingdom
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Inga B. Fricke
1European Institute for Molecular Imaging, Westfälische Wilhelms-Universität Münster, Münster, Germany
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Nathalie Just
2Department of Clinical Radiology, University Hospital of Münster, Münster, Germany
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Sabrina Doblas
6Laboratory of Imaging Biomarkers, UMR 1149–CRI, INSERM, Paris Diderot University, Paris, France
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Ralph Sinkus
7Imaging Sciences and Biomedical Engineering Division, Kings College, London, United Kingdom
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Christian Döring
1European Institute for Molecular Imaging, Westfälische Wilhelms-Universität Münster, Münster, Germany
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Klaus P. Schäfers
1European Institute for Molecular Imaging, Westfälische Wilhelms-Universität Münster, Münster, Germany
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John R. Griffiths
5Cancer Research U.K. Cambridge Institute, Cambridge, United Kingdom
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Cornelius Faber
2Department of Clinical Radiology, University Hospital of Münster, Münster, Germany
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Richard Schneider
8Merck KGaA, Darmstadt, Germany; and
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Eric O. Aboagye
4Comprehensive Cancer Imaging Centre, Imperial College London, London, United Kingdom
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Andreas H. Jacobs
1European Institute for Molecular Imaging, Westfälische Wilhelms-Universität Münster, Münster, Germany
9Department of Geriatric Medicine, Johanniter Hospital, Bonn, Germany
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Journal of Nuclear Medicine: 59 (7)
Journal of Nuclear Medicine
Vol. 59, Issue 7
July 1, 2018
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Thymidine Metabolism as a Confounding Factor for 3′-Deoxy-3′-18F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model
Sonja Schelhaas, Lydia Wachsmuth, Sven Hermann, Natascha Rieder, Astrid Heller, Kathrin Heinzmann, Davina J. Honess, Donna-Michelle Smith, Inga B. Fricke, Nathalie Just, Sabrina Doblas, Ralph Sinkus, Christian Döring, Klaus P. Schäfers, John R. Griffiths, Cornelius Faber, Richard Schneider, Eric O. Aboagye, Andreas H. Jacobs
Journal of Nuclear Medicine Jul 2018, 59 (7) 1063-1069; DOI: 10.2967/jnumed.117.206250

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Thymidine Metabolism as a Confounding Factor for 3′-Deoxy-3′-18F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model
Sonja Schelhaas, Lydia Wachsmuth, Sven Hermann, Natascha Rieder, Astrid Heller, Kathrin Heinzmann, Davina J. Honess, Donna-Michelle Smith, Inga B. Fricke, Nathalie Just, Sabrina Doblas, Ralph Sinkus, Christian Döring, Klaus P. Schäfers, John R. Griffiths, Cornelius Faber, Richard Schneider, Eric O. Aboagye, Andreas H. Jacobs
Journal of Nuclear Medicine Jul 2018, 59 (7) 1063-1069; DOI: 10.2967/jnumed.117.206250
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