Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer

Tessa Buckle; Danny M. van Willigen; Silvia J. Spa; Albertus W. Hensbergen; Steffen van der Wal; Clarize M. de Korne; Mick M. Welling; Henk G. van der Poel; James C.H. Hardwick; Fijs W.B. van Leeuwen

doi:10.2967/jnumed.117.205575

Research ArticleMolecular Imaging

Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer

Tessa Buckle, Danny M. van Willigen, Silvia J. Spa, Albertus W. Hensbergen, Steffen van der Wal, Clarize M. de Korne, Mick M. Welling, Henk G. van der Poel, James C.H. Hardwick and Fijs W.B. van Leeuwen

Journal of Nuclear Medicine June 2018, 59 (6) 986-992; DOI: https://doi.org/10.2967/jnumed.117.205575

Tessa Buckle

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

2Division of Molecular Pathology, Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

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Danny M. van Willigen

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

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Silvia J. Spa

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

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Albertus W. Hensbergen

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

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Steffen van der Wal

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

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Clarize M. de Korne

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

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Mick M. Welling

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

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Henk G. van der Poel

3Department of Urology, Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; and

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James C.H. Hardwick

4Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands

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Fijs W.B. van Leeuwen

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

3Department of Urology, Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; and

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Journal of Nuclear Medicine

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June 1, 2018

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Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer

Tessa Buckle, Danny M. van Willigen, Silvia J. Spa, Albertus W. Hensbergen, Steffen van der Wal, Clarize M. de Korne, Mick M. Welling, Henk G. van der Poel, James C.H. Hardwick, Fijs W.B. van Leeuwen

Journal of Nuclear Medicine Jun 2018, 59 (6) 986-992; DOI: 10.2967/jnumed.117.205575

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Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer

Tessa Buckle, Danny M. van Willigen, Silvia J. Spa, Albertus W. Hensbergen, Steffen van der Wal, Clarize M. de Korne, Mick M. Welling, Henk G. van der Poel, James C.H. Hardwick, Fijs W.B. van Leeuwen

Journal of Nuclear Medicine Jun 2018, 59 (6) 986-992; DOI: 10.2967/jnumed.117.205575

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Keywords

fluorescence
dual-modality
bimodal
hybrid
fluorescence-guided surgery
cyanine dyes

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Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer

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