PET and NAC in TNBC: Groheux comments on the demonstrated accuracy of change in SUVmax on 18F-FDG PET during neoadjuvant chemotherapy in predicting pathologic complete response in breast cancer and calls for similar trials in patients with triple-negative disease.
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Diagnostic radiopharmaceutical oversight: Schwarz and Clarke offer perspective on the U.S. evolution of review, assessment, and regulation of new radiopharmaceuticals and preview an article on this topic in this issue of JNM.
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FDA diagnostic radiopharmaceutical review: Marcus details the way in which the U.S. Food and Drug Administration considers diagnostic radiopharmaceuticals, focusing on common nonradioactive drugs and diagnostic radiopharmaceuticals and calling for formation of a standing advisory committee.
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PSMA in nonprostate cancers: Salas Fragomeni and colleagues provide a state-of-the-art overview of evidence-based studies and future promise of radiotracers targeting the prostate-specific membrane antigen in a potentially broad range of nonprostate cancers.
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α-Emitters for radiotherapy: Poty and colleagues, in the first of 2 educational reviews, explore the diversity, basic radiochemistry, restrictions, and hurdles of α-emitting radionuclides in cancer therapeutics.
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Small proteins for radionuclide imaging: Krasniqi and colleagues focus on small proteins that could allow same-day radionuclide-based imaging, with emphasis on clinical applications and promising preclinical developments in oncology.
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Machine learning in glioma: Papp and colleagues report on a study designed to establish and validate machine learning–driven survival models for glioma built on in vivo 11C-MET PET data, ex vivo characteristics, and patient data.
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First-in-human 89Zr-pertuzumab PET/CT: Ulaner and colleagues evaluate the safety, dosimetry, and pharmacokinetics of 89Zr-pertuzumab PET/CT for human epidermal growth factor receptor 2–targeted imaging in patients with HER2-positive breast cancer.
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From SSR agonists to antagonists: Bodei and Weber survey the development of somatostatin receptor–targeted imaging and therapy for neuroendocrine tumors and preview 2 articles in this issue of JNM on systematic evaluation of PET imaging with radiolabeled sstr2 antagonists.
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68Ga-OPS202 PET/CT phase I study: Nicolas and colleagues report on evaluation of this novel somatostatin receptor antagonist, including safety, biodistribution, dosimetry, and optimal imaging time-points in patients with gastroenteropancreatic neuroendocrine tumors.
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68Ga-OPS202 PET/CT phase II study: Nicolas and colleagues present the results of the phase II component of a phase I/II study evaluating the imaging sensitivity of 68Ga-OPS202, compared with that of 68Ga-DOTATOC, in patients with gastroenteropancreatic neuroendocrine tumors.
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68Ga-RM26 PET in prostate cancer: Zhang and colleagues analyze the safety, biodistribution, and radiation dosimetry of this gastrin-releasing peptide receptor antagonist PET tracer to assess its clinical diagnostic value in prostate cancer patients.
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PSMA+ total tumor volume and BED: Begum et al. simulate the effect of prostate-specific membrane antigen (PSMA)–positive total tumor volume on biologically effective doses in patients with metastatic castration-resistant prostate cancer undergoing 177Lu-PSMA radioligand therapy.
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α-RIT in solid tumors: Carlin looks at current challenges to routine clinical use of α-radioimmunotherapy and offers commentary on a recent related article in JNM.
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Test–retest evaluation of Flortaucipir F 18: Devous and colleagues report on test–retest reproducibility of PET imaging with this tracer for tau neurofibrillary tangles in healthy controls and individuals with mild cognitive impairment and Alzheimer disease.
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PERSI quantitation of Flortaucipir F 18: Southekal and colleagues present parametric estimation of reference signal intensity, a new technique for Flortaucipir F 18 count normalization that leverages the advantages of white matter reference regions while mitigating potential partial-volume effects.
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Exploring biomarkers for cocaine addiction: de Laat and colleagues detil findings in a rat model of cocaine self-administration monitored longitudinally using 18F-FPEB PET, proton MR spectroscopy, and behavioral tests.
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Tau imaging in Alzheimer tauopathy mice: Ni and colleagues use transgenic mouse models of tauopathies to compare in vivo imaging with both 11C-PBB3 PET and MR imaging to postmortem measures of tau probe binding.
Page 960
18F-FDG PET/MR imaging in chronic sciatica: Cipriano and colleagues report on a study assessing the feasibility of an 18F-FDG PET/MR imaging approach to improving diagnosis of chronic sciatica and possibly elucidating causative pathology.
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11C-Erlotinib PET in the human brain: Verheijen and colleagues describe the effects of the ABCB1 and ABCG2 transporter inhibitor elacridar on brain uptake using 11C-erlotinib PET in mice and in patients with advanced or metastatic solid tumors.
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Anti-CD4 immuno-PET in colitic mice: Freise and colleagues report on PET imaging with an antimouse CD4 antibody fragment targeting CD4-positive T cells in a mouse model of inflammatory bowel disease.
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Fluorescent dyes and tracer kinetics: Buckle and colleagues introduce a bimodal hybrid tracer design to systematically and quantitatively evaluate the influence of elongation of the polymethine chain in a fluorescent cyanine dye on the imaging potential of a targeted tracer.
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Mini-EXPLORER PET scanner: Berg and colleagues describe a long-axial-field-of-view PET scanner for high-sensitivity and total-body imaging of nonhuman primates and present the physical performance with first phantom and animal imaging results.
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Reproducibility of thoracic MR-AC maps: Olin and colleagues evaluate the quality of current vendor-provided thoracic MR attenuation correction maps and the reproducibility of their impact on 18F-FDG PET quantification in patients with non–small cell lung cancer.
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New-generation fetal dose estimates: Stabin provides revised radiopharmaceutical dose estimates to the fetus based on RAdiation Dose Assessment Resource International Commission on Radiological Protection 89 reference female pregnant and nonpregnant models.
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- © 2018 by the Society of Nuclear Medicine and Molecular Imaging.