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Research ArticleNeurology

Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models

Ruiqing Ni, Bin Ji, Maiko Ono, Naruhiko Sahara, Ming-Rong Zhang, Ichio Aoki, Agneta Nordberg, Tetsuya Suhara and Makoto Higuchi
Journal of Nuclear Medicine June 2018, 59 (6) 960-966; DOI: https://doi.org/10.2967/jnumed.117.201632
Ruiqing Ni
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Chiba 263-8555, Japan
2Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institute, Stockholm, Sweden; and
3Theme Aging, Karolinska University Hospital, Stockholm, Sweden
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Bin Ji
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Chiba 263-8555, Japan
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Maiko Ono
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Chiba 263-8555, Japan
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Naruhiko Sahara
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Chiba 263-8555, Japan
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Ming-Rong Zhang
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Chiba 263-8555, Japan
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Ichio Aoki
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Chiba 263-8555, Japan
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Agneta Nordberg
2Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institute, Stockholm, Sweden; and
3Theme Aging, Karolinska University Hospital, Stockholm, Sweden
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Tetsuya Suhara
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Chiba 263-8555, Japan
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Makoto Higuchi
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Chiba 263-8555, Japan
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Journal of Nuclear Medicine: 59 (6)
Journal of Nuclear Medicine
Vol. 59, Issue 6
June 1, 2018
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Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models
Ruiqing Ni, Bin Ji, Maiko Ono, Naruhiko Sahara, Ming-Rong Zhang, Ichio Aoki, Agneta Nordberg, Tetsuya Suhara, Makoto Higuchi
Journal of Nuclear Medicine Jun 2018, 59 (6) 960-966; DOI: 10.2967/jnumed.117.201632

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Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models
Ruiqing Ni, Bin Ji, Maiko Ono, Naruhiko Sahara, Ming-Rong Zhang, Ichio Aoki, Agneta Nordberg, Tetsuya Suhara, Makoto Higuchi
Journal of Nuclear Medicine Jun 2018, 59 (6) 960-966; DOI: 10.2967/jnumed.117.201632
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Keywords

  • tauopathy
  • Transgenic mouse model
  • small-animal PET
  • Volumetric MRI
  • Radioligand binding
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